| Project/Area Number |
15H06805
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 活性型グレリン / 抗肥満 / トリテルペン類 / カルボキシル基 / EGCG / トリテルペン / グレリン / 天然化合物 / 摂食抑制 / 肥満 / 食欲抑制 |
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| Outline of Final Research Achievements |
We screened for compounds with inhibitory effect on the production of active ghrelin, an appetite-stimulating peptide hormone. We found that triterpenes with carboxylic group, such as asiatic acid, oleanolic acid and glycyrrhetinic acid as well as epigallocatechin gallate (EGCG) suppressed active ghrelin production in the ghrelin-expressing cell line, AGS-GHRL8. Furthermore, oleanolic acid and EGCG decreased the plasma level of active ghrelin in mice. These triterpenes and EGCG are useful for the development of agents for prevention and treatment of obesity by suppressing active ghrelin production.
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