Pathway-specific neuronal modulation by DREADD system in primates

Research Project

Project/Area Number	15H06872
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Basic / Social brain science
Research Institution	National Institutes for Quantum and Radiological Science and Technology
Principal Investigator	Fujimoto Atsushi 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所脳機能イメージング研究部, 博士研究員(任常) (20756390)
Project Period (FY)	2015-08-28 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	サル / DREADD / 基底核 / 意思決定 / 報酬 / 背側線条体 / 腹側淡蒼球 / 線条体
Outline of Final Research Achievements	Inhibitory-DREADD (hM4Di) was surgically introduced to the bilateral rostromedial caudate (rmCD) of two monkeys. Systemic infusion of an hM4Di-selective ligand Clozapine-N-Oxide (CNO) reversibly impaired a value-based behavior of the monkeys. Neuronal recordings of the rmCD and the ventral pallidum (VP) revealed strong value coding in these areas, and the faster encoding of predicted reward value in the VP. Our results suggest that the rmCD->VP pathway could facilitate the maintenance of reward information rather than reward prediction itself.

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(3 results)