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The involvement of leucine rich alpha-2 glycoprotein in the inflammasome of macrophage

Research Project

Project/Area Number 15H06918
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionNational Institutes of Biomedical Innovation, Health and Nutrition

Principal Investigator

Urushima Hayato  国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 免疫シグナルプロジェクト, 協力研究員 (90755745)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords免疫学 / 腸炎 / 単球 / 血管内皮
Outline of Final Research Achievements

Leucine-rich α2-glycoprotein (LRG) has been identified as a disease activity marker of inflammatory diseases including inflammatory bowel disease (IBD). However, the roles of LRG in these diseases has not yet been clarified. We analyzed the function of LRG by using of DSS-induced colitis mice model of IBD. LRG deficiency led to decrease of infiltration of inflammatory cells such as neutrophil and macrophage. LRG upregulated the expression of endoglin which is an adhesion molecule via promotion of TGFβ-Smad1 pathway in vascular endothelium.
Taken together, our data suggest that LRG accelerates the traficking of leukocyte by upregulation of adhesion molecule in vascular endothelial cells, leading to progression of colonic inflammation.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report

Research Products

(1 results)

All 2016

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Leucine-rich α2-glycoprotein (LRG) enhances colonic inflammation by increasing leukocyte adhesion to TGF-β-stimulated endothelium2016

    • Author(s)
      Takashi Mishima, Hayato Urushima, Minoru Fujimoto, Hiromi Honda, Lee Hyun, Tomoharu Ohkawara, Satoshi Serada, Tetsuji Naka
    • Organizer
      The 13th International Workshop on Autoantibodies and Autoimmunity (IWAA2016)
    • Place of Presentation
      ウエスティン都ホテル京都(京都市東山区)
    • Year and Date
      2016-10-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research

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Published: 2015-08-26   Modified: 2018-03-22  

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