A novel role of Plectin in ionizing radiation-induced DNA damage response
| Project/Area Number |
15K00546
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation and chemicals
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | DNA損傷応答 / プレクチン |
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| Outline of Final Research Achievements |
Plectin is known as a link between components of cytoskeletons to maintain cell structure. In this study, we found that Plectin also plays a role in DNA damage response in human cells. We identified Plectin as a substrate of ATM, which is activated by ionizing radiation-induced DNA double-strand breaks and controls cell cycle arrest, DNA repair, and cell death. Furthermore, we found that Plectin regulates cell cycle arrest by controlling activation of tumor suppressor p53 after ionizing radiation.
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| Academic Significance and Societal Importance of the Research Achievements |
放射線は、空から降り注ぐ宇宙線や、医療用のレントゲンやCTスキャンなどごく身近に存在しているものであるが、近年、原発事故による放射能漏れ等の報道により、放射線の人体に与える影響について社会的な関心が高まっている。本研究成果では、放射線により、代表的な癌抑制遺伝子産物であるp53蛋白質の活性化を調節する仕組みの一部が解明された。これにより、放射線の人体に与える影響の全容解明につながることが期待される。
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Report
(5 results)
Research Products
(1 results)
