| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Plectin is known as a link between components of cytoskeletons to maintain cell structure. In this study, we found that Plectin also plays a role in DNA damage response in human cells. We identified Plectin as a substrate of ATM, which is activated by ionizing radiation-induced DNA double-strand breaks and controls cell cycle arrest, DNA repair, and cell death. Furthermore, we found that Plectin regulates cell cycle arrest by controlling activation of tumor suppressor p53 after ionizing radiation.
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