The effect of rosemary components on the stress-related disease risk
| Project/Area Number |
15K00823
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Saga University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松原 主典 広島大学, 教育学研究科, 准教授 (90254565)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | カルノシン酸 / ローズマリー / ストレス / マウス / 腸内環境 / 抗ストレス効果 / 精神的ストレス / 拘束ストレス / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
We investigated the effects of carnosic acid (CA) and CA-containing rosemary leaf extract (RLE) on restraint-stressed mice. The increases in serum IL-6 and corticosterone levels caused by restraint treatment were alleviated by intake CA. In addition, the decrease in intestinal goblet cell number caused by restraint treatment was improved by RLE intake. Furthermore, we found that the restraint-stress effect on liver lipid content was alleviated by RLE. Our results suggest that CA has the beneficial anti-stress effect. It is possible that the CA might exert an alleviation effect against the stress-related disease risk.
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Report
(4 results)
Research Products
(4 results)
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[Presentation] Comparison of biological activities between carnosic acid and piciferic acid2017
Author(s)
Shibata, S., Kayashima, T.,Ishitobi, H., Miyaki, S., Kawaoka, T., Matsubara, K
Organizer
FFC’s 21st International Conference and Expo on Functional Foods
Related Report
Int'l Joint Research
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