| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We investigated the effects of carnosic acid (CA) and CA-containing rosemary leaf extract (RLE) on restraint-stressed mice. The increases in serum IL-6 and corticosterone levels caused by restraint treatment were alleviated by intake CA. In addition, the decrease in intestinal goblet cell number caused by restraint treatment was improved by RLE intake. Furthermore, we found that the restraint-stress effect on liver lipid content was alleviated by RLE. Our results suggest that CA has the beneficial anti-stress effect. It is possible that the CA might exert an alleviation effect against the stress-related disease risk.
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