Studies on mechanism of metabolic regulation of vitamin A and beta-carotene and their nutritional status-related biological regulation.

• Project/Area Number: 15K00835
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: University of Nagasaki
• Principal Investigator: SURUGA KAZUHITO 長崎県立大学, 看護栄養学部, 准教授 (70315852)
• Co-Investigator(Kenkyū-buntansha): 山口 範晃 長崎県立大学, 看護栄養学部, 助教 (80516295)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: ビタミンA / β-カロテン / アルコール / 高脂肪食 / 妊娠・授乳期 / 耐糖能異常 / ロコモティブシンドローム / 2型糖尿病 / 卵巣摘出 / 骨量低下 / 筋委縮 / 脂質代謝 / β‐カロテン / 脂質吸収・代謝 / DOHaD / 小腸 / 低たんぱく質食 / スナネズミ

Outline of Final Research Achievements

Intake of alcohol and high-fat diet led to suppress the oxidative cleavage conversion of beta-carotene into vitamin A via alteration of expression level of two ranscription factors, ISX and PPAR-delta, in rat small intestine. Vitamin A-nutritional status during pregnancy/lactation affected the synthesis and catabolism of retinoic acid and the absorption and metabolic function of β-carotene in rat pups during the peri-weaning period. Sufficient ingestion of dietary vitamin A and β-carotene resulted in improving impaired glucose tolerance and abnormal lipid metabolism.

Research Products

• [Journal Article] A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet (2018)
  • Author(s): Katsuhisa Omagari, Kazuhito Suruga, Akira Kyogoku, Satomi Nakamura, Ai Sakamoto, Shinta Nishioka, Mayuko Ichimura, Yuji Miyata, Koichi Tajima, Koichi Tsuneyama, Kazunari Tanaka
  • Journal Title: Hepatobiliary Surgery and Nutrition Volume: － Issue: 3 Pages: 175-184
  • DOI: 10.21037/hbsn.2017.08.03
  • Peer Reviewed / Open Access
• [Journal Article] A diet-induced Sprague-Dawley rat model of nonalcoholic steatohepatitis-related cirrhosis. (2017)
  • Author(s): Ichimura M, Masuzumi M, Kawase M, Sakaki M, Tamaru S, Nagata Y, Tanaka K, Suruga K, Tsuneyama K, Matsuda S, Omagari K.
  • Journal Title: Journal of Nutritional Biochemistry Volume: 40 Pages: 62-69
  • DOI: 10.1016/j.jnutbio.2016.10.007
  • Peer Reviewed
• [Presentation] ビタミンA過剰摂取は高脂肪食摂取マウスの体脂肪を減少させ過剰症を伴う (2017)
  • Author(s): 山口範晃、駿河和仁
  • Organizer: 第69回日本ビタミン学会
• [Presentation] アルコール摂取がラットのビタミンAおよびβーカロテンの代謝変動に及ぼす影響 (2016)
  • Author(s): 西村玲泉、山口範昭、駿河和仁
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 兵庫県西宮市・武庫川女子大学中央キャンパス
  • Year and Date: 2016-05-14
• [Presentation] ビタミンA過剰摂取はマウスのエネルギー消費量を上昇させ体脂肪を減少させる (2016)
  • Author(s): 山口範昭、駿河和仁
  • Organizer: 第70回日本栄養・食糧学会大会
  • Place of Presentation: 兵庫県西宮市・武庫川女子大学中央キャンパス
  • Year and Date: 2016-05-14
• [Presentation] アルコール摂取がラットのビタミンAおよびβ-カロテンの代謝変動に及ぼす影響 (2016)
  • Author(s): 西村玲泉、山口範晃、駿河和仁
  • Organizer: 日本栄養・食糧学会70回大会
  • Place of Presentation: 武庫川女子大学（兵庫県西宮市）
  • Year and Date: 2016-05-13
• [Presentation] ビタミンA過剰摂取はマウスのエネルギー消費量を上昇させ体脂肪を減少させる (2016)
  • Author(s): 山口範晃、駿河和仁
  • Organizer: 日本栄養・食糧学会70回大会
  • Place of Presentation: 武庫川女子大学（兵庫県西宮市）
  • Year and Date: 2016-05-13
• [Presentation] 空腸β-カロテン開裂酵素(BCMO1)発現誘導の高脂肪食摂取による低下とその要因 (2015)
  • Author(s): 高瀬幸子、五十嵐美樹、山口範晃、駿河和仁
  • Organizer: 日本ビタミン学会第67回大会
  • Place of Presentation: 奈良市・奈良県新公会堂
  • Year and Date: 2015-06-05
• [Presentation] The excess intake of vitamin A increases energy expenditure, and decreases fat mat of high-fat diet induced-obese mice (2015)
  • Author(s): Noriaki Yamaguchi, Eri Abe, Kazuhito Suruga
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: 横浜市西区・パシフィコ横浜
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Effects of dietary high-fat feeding on gene expression of beta-carotene and retinoids metabolism-related enzymes in small intestine and liver (2015)
  • Author(s): Sachiko Takase, Miki Igarashi, Noriaki Yamaguchi, Toshinao Goda, Kazuhito Suruga
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: 横浜市西区・パシフィコ横浜
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Book] 応用栄養学 ライフステージ別の栄養ケア・マネジメントを正しく理解するために (2017)
  • Author(s): 浅田裕一、今井絵里、上山恵子、北島幸枝、小玉智章、駿河和仁、多賀昌樹、宮本啓子、元永恵子、山城秋美
  • Total Pages: 232
  • Publisher: 化学同人