Studies on mechanism of metabolic regulation of vitamin A and beta-carotene and their nutritional status-related biological regulation.
| Project/Area Number |
15K00835
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | University of Nagasaki |
|---|
Principal Investigator |
SURUGA KAZUHITO 長崎県立大学, 看護栄養学部, 准教授 (70315852)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
山口 範晃 長崎県立大学, 看護栄養学部, 助教 (80516295)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | ビタミンA / β-カロテン / アルコール / 高脂肪食 / 妊娠・授乳期 / 耐糖能異常 / ロコモティブシンドローム / 2型糖尿病 / 卵巣摘出 / 骨量低下 / 筋委縮 / 脂質代謝 / β‐カロテン / 脂質吸収・代謝 / DOHaD / 小腸 / 低たんぱく質食 / スナネズミ |
|---|
| Outline of Final Research Achievements |
Intake of alcohol and high-fat diet led to suppress the oxidative cleavage conversion of beta-carotene into vitamin A via alteration of expression level of two ranscription factors, ISX and PPAR-delta, in rat small intestine. Vitamin A-nutritional status during pregnancy/lactation affected the synthesis and catabolism of retinoic acid and the absorption and metabolic function of β-carotene in rat pups during the peri-weaning period. Sufficient ingestion of dietary vitamin A and β-carotene resulted in improving impaired glucose tolerance and abnormal lipid metabolism.
|
Report
(4 results)
Research Products
(11 results)
-
[Journal Article] A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet2018
Author(s)
Katsuhisa Omagari, Kazuhito Suruga, Akira Kyogoku, Satomi Nakamura, Ai Sakamoto, Shinta Nishioka, Mayuko Ichimura, Yuji Miyata, Koichi Tajima, Koichi Tsuneyama, Kazunari Tanaka
-
Journal Title
Hepatobiliary Surgery and Nutrition
Volume: －
Issue: 3
Pages: 175-184
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] A diet-induced Sprague-Dawley rat model of nonalcoholic steatohepatitis-related cirrhosis.2017
Author(s)
Ichimura M, Masuzumi M, Kawase M, Sakaki M, Tamaru S, Nagata Y, Tanaka K, Suruga K, Tsuneyama K, Matsuda S, Omagari K.
-
Journal Title
Journal of Nutritional Biochemistry
Volume: 40
Pages: 62-69
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
