Establishment and clinical application of a diet program to improve myocardial fatty acid metabolism in cardiovascular disease

• Project/Area Number: 15K00845
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Juntendo University
• Principal Investigator: MIYAZAKI Tetsuro 順天堂大学, 医学部, 准教授 (30600473)
• Research Collaborator: FUJIMOTO shinichiro ; AIKAWA masanori ; HIKI makoto ; MATSUMORI rie
• Project Period (FY): 2015-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 脂肪酸 / 微量栄養素 / 心筋内中性脂肪 / 心血管疾患 / 食事プログラム / バイオマーカー / 脂肪酸代謝 / MRS / 静脈血栓症 / せん妄 / ミトコンドリア代謝 / CICU

Outline of Final Research Achievements

An effective diet program for cardiovascular disease patients has not been established. The purpose of this study is to establish a dietary program focusing on fatty acid balance, fatty acid metabolism in the myocardium and nutrients related to mitochondrial metabolism. The present study revealed that in cardiovascular disease patients, especially elderly malnourished patients, the shortage of mitochondrial metabolism related nutrients such as ω-6 fatty acid, carnitine, and coenzyme Q10 were associated with poor prognosis. With regard to ω-3 fatty acids, in addition to the beneficial effects on ischemic heart disease, it is suggested that it may be effective in suppressing the development of aortic aneurysm and venous thrombosis. Moreover, the examination using 1H-MRS method clarified the difference in the disease specific myocardial fatty acid metabolism.

Academic Significance and Societal Importance of the Research Achievements

本研究の最終的な目的は、心血管疾患発症・再発予防に有効な食事プログラムを開発することである。また脂肪酸摂取による介入の心筋脂内中性脂肪量への影響を基礎的・臨床的に検証し、心筋脂肪酸代謝に対する有効な介入法を確立することも目的としている。本研究で得られた成果から、脂肪酸を含むミトコンドリア代謝関連栄養素の重要性が改めて明らかとなった。また従来顧みられなかったω－６系脂肪酸の重要性も明らかとなった。本結果を、心疾患に対する新たなかつ効果的な食事プログラム、治療法の開発に繋げることにより、国民健康の維持増進、心筋脂肪酸代謝をターゲットとした創薬等の医療技術の向上にも貢献すると考えられる。

Research Products

• [Journal Article] Different prognostic associations of beta-blockers and diuretics in heart failure with preserved ejection fraction with versus without high blood pressure (2019)
  • Author(s): Matsushita Kenichi、Harada Kazumasa、Miyazaki Tetsuro、Miyamoto Takamichi、Kohsaka Shun、Iida Kiyoshi、Tanimoto Shuzou、Takei Makoto、Hosoda Toru、Yamamoto Yoshiya、Shiraishi Yasuyuki、Yoshino Hideaki、Yamamoto Takeshi、Nagao Ken、Takayama Morimasa
  • Journal Title: Journal of Hypertension Volume: 37 Issue: 3 Pages: 643-649
  • DOI: 10.1097/hjh.0000000000001932
  • Peer Reviewed / Open Access
• [Journal Article] Relationship Between Serum Sodium Level Within the Low-Normal Range on Admission and Long-Term Clinical Outcomes in Patients with Acute Decompensated Heart Failure (2018)
  • Author(s): Hiki Masaru、Kasai Takatoshi、Yatsu Shoichiro、Murata Azusa、Matsumoto Hiroki、Kato Takao、Suda Shoko、Miyazaki Tetsuro、Takagi Atsutoshi、Daida Hiroyuki
  • Journal Title: International Heart Journal Volume: 59 Issue: 5 Pages: 1052-1058
  • DOI: 10.1536/ihj.17-524
  • NAID: 130007490590
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2018-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Age Stratification and Impact of Eicosapentaenoic Acid and Docosahexaenoic Acid to Arachidonic Acid Ratios in Ischemic Stroke Patients (2018)
  • Author(s): Ueno Y, Tanaka R, Yamashiro K, Miyamoto N, Hira K, Kurita N, Sakurai M, Urabe T, Shimada K, Miyazaki T, Daida H, Hattori N
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 7 Pages: 593-605
  • DOI: 10.5551/jat.40691
  • NAID: 130007386958
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-07-01
  • Peer Reviewed / Open Access
• [Journal Article] Correlation of Nutritional Indices on Admission to the Coronary Intensive Care Unit with the Development of Delirium (2018)
  • Author(s): Sugita Yurina、Miyazaki Tetsuro、Shimada Kazunori、Shimizu Megumi、Kunimoto Mitsuhiro、Ouchi Shohei、Aikawa Tatsuro、Kadoguchi Tomoyasu、Kawaguchi Yuko、Shiozawa Tomoyuki、Takasu Kiyoshi、Hiki Masaru、Takahashi Shuhei、Sumiyoshi Katsuhiko、Iwata Hiroshi、Daida Hiroyuki
  • Journal Title: Nutrients Volume: 10 Issue: 11 Pages: 1712-1712
  • DOI: 10.3390/nu10111712
  • Peer Reviewed / Open Access
• [Journal Article] Possible Role of NADPH Oxidase 4 in Angiotensin II-Induced Muscle Wasting in Mice (2018)
  • Author(s): Kadoguchi Tomoyasu、Shimada Kazunori、Koide Hiroshi、Miyazaki Tetsuro、Shiozawa Tomoyuki、Takahashi Shuhei、Aikawa Tatsuro、Ouchi Shohei、Kitamura Kenichi、Sugita Yurina、Hamad Al Shahi、Kunimoto Mitsuhiro、Sato-Okabayashi Yayoi、Akita Koji、Isoda Kikuo、Daida Hiroyuki
  • Journal Title: Frontiers in Physiology Volume: 9 Pages: 1-9
  • DOI: 10.3389/fphys.2018.00340
  • Peer Reviewed / Open Access
• [Journal Article] Effects of glycemic control on in-hospital mortality among acute heart failure patients with reduced, mid-range, and preserved ejection fraction (2018)
  • Author(s): Matsushita Kenichi、Harada Kazumasa、Miyazaki Tetsuro、Miyamoto Takamichi、Iida Kiyoshi、Tanimoto Shuzou、Yagawa Mayuko、Takei Makoto、Nagatomo Yuji、Hosoda Toru、Yoshino Hideaki、Yamamoto Takeshi、Nagao Ken、Takayama Morimasa
  • Journal Title: Heart and Vessels Volume: 33 Issue: 9 Pages: 1022-1028
  • DOI: 10.1007/s00380-018-1152-2
  • NAID: 40022187675
  • Peer Reviewed / Open Access
• [Journal Article] Left Atrial Appendage Volume and Plasma Docosahexaenoic Acid Levels Are Associated With Atrial Fibrillation Recurrence After Catheter Ablation (2017)
  • Author(s): Shiozawa Tomoyuki、Shimada Kazunori、Sekita Gaku、Hayashi Hidemori、Tabuchi Haruna、Miura Seiji、Fujimoto Shinichiro、Kadoguchi Tomoyasu、Ouchi Shohei、Aikawa Tatsuro、Al Shahi Hamad、Takahashi Shuhei、Miyazaki Tetsuro、Sumiyoshi Masataka、Nakazato Yuji、Daida Hiroyuki
  • Journal Title: Cardiology Research Volume: 8 Issue: 3 Pages: 96-104
  • DOI: 10.14740/cr542w
  • Peer Reviewed / Open Access
• [Journal Article] Decreased circulating dihomo-gamma-linolenic acid levels are associated with total mortality in patients with acute cardiovascular disease and acute decompensated heart failure (2017)
  • Author(s): Ouchi Shohei、Miyazaki Tetsuro、Shimada Kazunori、Sugita Yurina、Shimizu Megumi、Murata Azusa、Kato Takao、Aikawa Tatsuro、Suda Shoko、Shiozawa Tomoyuki、Hiki Masaru、Takahashi Shuhei、Kasai Takatoshi、Miyauchi Katsumi、Daida Hiroyuki
  • Journal Title: Lipids in Health and Disease Volume: 16 Issue: 1 Pages: 150-150
  • DOI: 10.1186/s12944-017-0542-2
  • Peer Reviewed / Open Access
• [Journal Article] Low Docosahexaenoic Acid, Dihomo-Gamma-Linolenic Acid, and Arachidonic Acid Levels Associated with Long-Term Mortality in Patients with Acute Decompensated Heart Failure in Different Nutritional Statuses (2017)
  • Author(s): Shohei Ouchi、Tetsuro Miyazaki、Kazunori Shimada、Yurina Sugita、Megumi Shimizu、Azusa Murata、Takao Kato、Tatsuro Aikawa、Shoko Suda、Tomoyuki Shiozawa、Masaru Hiki、Shuhei Takahashi、Hiroshi Iwata、Takatoshi Kasai、Katsumi Miyauchi、Hiroyuki Daida
  • Journal Title: Nutrients Volume: 9 Issue: 9 Pages: 956-956
  • DOI: 10.3390/nu9090956
  • Peer Reviewed / Open Access
• [Journal Article] Low 1,5-anhydroglucitol levels are associated with long-term cardiac mortality in acute coronary syndrome patients with hemoglobin A1c levels less than 7.0% (2017)
  • Author(s): Ouchi Shohei、Shimada Kazunori、Miyazaki Tetsuro、Takahashi Shuhei、Sugita Yurina、Shimizu Megumi、Murata Azusa、Kadoguchi Tomoyasu、Kato Takao、Aikawa Tatsuro、Suda Shoko、Sai Eiryu、Hiki Masaru、Iwata Hiroshi、Kasai Takatoshi、Miyauchi Katsumi、Daida Hiroyuki
  • Journal Title: Cardiovascular Diabetology Volume: 16 Issue: 1 Pages: 1-9
  • DOI: 10.1186/s12933-017-0636-1
  • Peer Reviewed / Open Access
• [Journal Article] Myocardial triglyceride content in patients with left ventricular hypertrophy: Comparison between hypertensive heart disease and hypertrophic cardiomyopathy. (2017)
  • Author(s): Sai E, Shimada K, Yokoyama T, Hiki M, Sato S, Hamasaki N, Maruyama M, Morimoto R, Miyazaki T, Fujimoto S, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H.
  • Journal Title: Heart Vessels Volume: 32 Issue: 2 Pages: 166-174
  • DOI: 10.1007/s00380-016-0844-8
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Low Serum Levels of EPA are Associated with the Size and Growth Rate of Abdominal Aortic Aneurysm (2017)
  • Author(s): 44.Aikawa T, Miyazaki T, Shimada K, Sugita Y, Shimizu M, Ouchi S, Kadoguchi T, Yokoyama Y, Shiozawa T, Hiki M, Takahashi S, Al Shahi H, Dohi S, Amano A, Daida H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 9 Pages: 912-920
  • DOI: 10.5551/jat.38315
  • NAID: 130006038434
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Significance of Serum Polyunsaturated Fatty Acid Level Imbalance in Patients with Acute Venous Thromboembolism (2017)
  • Author(s): Hiki M, Miyazaki T, Shimada K, Sugita Y, Shimizu M, Aikawa T, Ouchi S, Shiozawa T, Takasu K, Takahashi S, Takagi A, Miyauchi K, Daida H
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 10 Pages: 1016-1022
  • DOI: 10.5551/jat.37424
  • NAID: 130006110246
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Increased cystatin C levels as a risk factor of cardiovascular events in patients with preserved estimated glomerular filtration rate after elective percutaneous coronary intervention with drug-eluting stents. (2016)
  • Author(s): Sai E, Shimada K, Miyauchi K, Masaki Y, Kojima T, Miyazaki T, Kurata T, Ogita M, Tsuboi S, Yoshihara T, Miyazaki T, Ohsaka A, Daida H
  • Journal Title: Heart Vessels Volume: 31 Issue: 5 Pages: 694-701
  • DOI: 10.1007/s00380-015-0674-0
  • Peer Reviewed / Open Access
• [Journal Article] Association between the docosahexaenoic acid to arachidonic acid ratio and acute coronary syndrome: a multicenter observational study. (2016)
  • Author(s): Nishizaki Y, Shimada K, Tani S, Ogawa T, Ando J, Takahashi M, Yamamoto M, Shinozaki T, Miyazaki T, Miyauchi K, Nagao K, Hirayama A, Yoshimura M, Komuro I, Nagai R, Daida H.
  • Journal Title: BMC Cardiovascular Disorders Volume: 16 Issue: 1 Pages: 143-143
  • DOI: 10.1186/s12872-016-0299-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Low and exacerbated levels of 1,5-anhydroglucitol are associated with cardiovascular events in patients after first-time elective percutaneous coronary intervention (2016)
  • Author(s): Takahashi S, Shimada K, Miyauchi K, Miyazaki T, Sai E, Ogita M, Tsuboi S, Tamura H, Okazaki S, Shiozawa T, Ouchi S, Aikawa T, Kadoguchi T, Al Shahi H, Yoshihara T, Hiki M, Isoda K, Daida H
  • Journal Title: Cardiovasc Diabetol Volume: 15 Issue: 1 Pages: 145-145
  • DOI: 10.1186/s12933-016-0459-5
  • Peer Reviewed / Open Access
• [Journal Article] Correlation of Pre- and In-Hospital Systolic Blood Pressure in Acute Heart Failure Patients and the Prognostic Implications – Report From the Tokyo Cardiac Care Unit Network Emergency Medical Service Database – (2016)
  • Author(s): Shiraishi Y, Kohsaka S, Harada K, Miyamoto T, Tanimoto S, Iida K, Sakai T, Miyazaki T, Yagawa M, Matsushita K, Furihata S, Sato N, Fukuda K, Yamamoto T, Nagao K, Takayama M; Tokyo CCU Network Scientific Committee
  • Journal Title: Circulation Journal Volume: 80 Issue: 12 Pages: 2473-2481
  • DOI: 10.1253/circj.CJ-16-0837
  • NAID: 130005284966
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Low circulating coenzyme Q10 during acute phase is associated with inflammation, malnutrition, and in-hospital mortality in patients admitted to the coronary care unit (2016)
  • Author(s): Shimizu M, Miyazaki T, Takagi A, Sugita Y, Yatsu S, Murata A, Kato T, Suda S, Ouchi S, Aikawa T, Hiki M, Takahashi S, Hiki M, Hayashi H, Kasai T, Shimada K, Miyauchi K, Daida H
  • Journal Title: Heart Vessels Volume: 印刷中 Issue: 6 Pages: 668-673
  • DOI: 10.1007/s00380-016-0923-x
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Myocardial Triglyceride Accumulation Assessed on ¹H-Magnetic Resonance Spectroscopy in Apparently Healthy Japanese Subjects (2015)
  • Author(s): Sai E, Shimada K, Yokoyama T, Sato S, Nishizaki Y, Miyazaki T, Hiki M, Tamura Y, Aoki S, Watada H, Kawamori R, Daida H.
  • Journal Title: Internal Medicine Volume: 54 Issue: 4 Pages: 367-373
  • DOI: 10.2169/internalmedicine.54.3024
  • NAID: 130004903049
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Omega 3 Polyunsaturated Fatty Acids Suppress the Development of Aortic Aneurysms Through the Inhibition of Macrophage-Mediated Inflammation (2015)
  • Author(s): Yoshihara T, Shimada K, Fukao K, Sai E, Sato-Okabayashi Y, Matsumori R, Shiozawa T, Alshahi H, Miyazaki T, Tada N, Daida H
  • Journal Title: Circulation Journal Volume: 79 Issue: 7 Pages: 1470-1478
  • DOI: 10.1253/circj.CJ-14-0471
  • NAID: 130005083946
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Association between tissue accumulation of advanced glycation end products and exercise tolerance in patients who have undergone cardiac rehabilitation. (2018)
  • Author(s): Kunimoto M, Shimada K, Yokoyama M, Aikawa T, Ouchi S, Shimizu M, Fukao K, Miyazaki T, Fujiwara K, Honzawa A, Yamada M, Shimada A, Yamamoto T, Amano A, Daida H
  • Organizer: European Society of Cardiology 2018
• [Presentation] Angiotensin II-dependent activation of NADPH oxidase 4 contributes to muscle wasting in mice via downregulation of NF-E2-related factor 2 (2018)
  • Author(s): Kadoguchi T, Shimada K, Miyazaki T, Aikawa T, Ouchi S, Kitamura K, Kunimoto M, Sugita Y, Shiozawa T, Isoda K, Daida H
  • Organizer: European Society of Cardiology 2018
• [Presentation] Low serum vitamin D levels are associated with polyunsaturated fatty acids, inflammation and long-term mortality in patients with acute cardiovascular disease (2018)
  • Author(s): Aikawa T, Miyazaki T, Shimada K, Sugita Y, Kitamura K, Kunimoto M, Shimizu M, Ouchi S, Shiozawa T, Kadoguchi T, Hiki M, Takahashi S, Daida H
  • Organizer: European Society of Cardiology 2018
• [Presentation] Malnutrition and low omega 6 PUFA levels on admission were associated with the development of delirium in patients with acute cardiovascular disease admitted to coronary care unit (2018)
  • Author(s): Sugita Y, Miyazaki T, Shimizu M, Kunimoto M, Aikawa T, Ouchi S, Kadoguchi T, Kawaguchi Y, Shiozawa T, Takahashi K, Hiki M, Yokoyama M, Iwata Y, Shimada K, Daida H
  • Organizer: European Society of Cardiology 2018
• [Presentation] Malnutrition and low omega 6 PUFA levels on admission affect the development of delirium in patients with acute cardiovascular disease admitted to coronary care unit (2018)
  • Author(s): Sugita Y, Miyazaki T, Shimada K, Shimizu M, Kunimoto M, Aikawa T, Ouchi S, Kadoguchi T, Kawaguchi Y, Shiozawa T, Takasu K, Hiki M, Takahashi S, Yokoyama M, Iwata H, Daida H
  • Organizer: American Heart Association 2018
• [Presentation] 急性心血管疾患における栄養指標とせん妄との関連 (2018)
  • Author(s): 杉田有里那, 宮崎哲朗, 清水めぐみ, 大内翔平, 相川達郎, 比企優, 岩田洋, 島田和典, 代田浩之
  • Organizer: 日本内科学会総会
• [Presentation] 大動脈瘤モデルマウスにおける短期間メトトレキサート投与効果の検討 (2018)
  • Author(s): 大内翔平, 宮崎哲朗, 島田和典, 杉田有里那, 門口智泰, 清水めぐみ, 相川達郎, 塩澤知之, 高橋秀平, 代田浩之
  • Organizer: 日本内科学会総会
• [Presentation] Angiotensin II誘発性筋肉消耗はNF-E2 related factor 2を介したNADPH oxidase 4由来酸化ストレスにより制御される (2018)
  • Author(s): 門口智泰, 島田和典, 宮崎哲朗, 塩澤知之, 高橋秀平, 相川達郎, 大内翔平, 喜多村健一, 杉田有里那, 國本充洋, 佐藤弥生, 磯田菊生, 代田浩之
  • Organizer: 日本循環器学会学術集会
• [Presentation] Methotrexateによる短期治療によりマウス腹部大動脈瘤モデルの大動脈瘤進行およびマクロファージ浸潤が予防される (2018)
  • Author(s): 大内翔平, 宮崎哲朗, 島田和典, 杉田有里那, 門口智泰, 清水めぐみ, 相川達郎, 塩澤知之, 比企優, 高橋秀平, 代田浩之
  • Organizer: 日本循環器学会学術集会
• [Presentation] 急性心血管疾患患者のせん妄発症における栄養指標の重要性 (2018)
  • Author(s): 杉田有里那, 宮崎哲朗, 島田和典, 清水めぐみ, 國本充洋, 大内翔平, 相川達郎, 川口裕子, 塩澤知之, 高須清, 比企優, 高橋秀平, 横山美帆, 岩田洋, 代田浩之
  • Organizer: 日本心臓病学会
• [Presentation] Association of low omega-6 polyunsaturated fatty acid levels on admission with delirium in coronary care unit (2018)
  • Author(s): Sugita Y, Miyazaki T, Shimizu M, Ouchi S, Aikawa T, Kadoguchi T, Kawaguchi Y, Shiozawa T, Takahashi S, Kasai T, Iwata H, Shimada K, Daida H
  • Organizer: 第82回 日本循環器学会学術集会
• [Presentation] Short-term methotrexate treatment prevents aortic aneurysm progression and macrophage In- filtration in mouse models of abdominal aortic aneurysms (2018)
  • Author(s): 大内翔平、宮﨑哲朗、島田和典、杉田有里那、 門口智泰、清水めぐみ、相川達郎、塩澤知之、 比企優、髙橋秀平、代田浩之
  • Organizer: 第82回 日本循環器学会学術集会
• [Presentation] Decreased Circulating DGLA Levels and DGLA/AA are Associated with Total Mortality in Patients with Acute Decompensated Heart Failure. (2017)
  • Author(s): 大内翔平, 宮崎哲朗, 島田和典, 杉田有里那, 清水めぐみ, 村田梓, 加藤隆生, 相川達郎, 須田翔子, 塩澤知之, 比企優, 髙橋秀平, 葛西隆敏, 宮内克己, 代田浩之
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他 (金沢)
  • Year and Date: 2017-03-17
• [Presentation] Exercise Training Ameliorates Cardiac Inflammation and Improves Left Ventricular Function after Myocardial Infarction in a Mouse Model. (2017)
  • Author(s): Al Shahi H, Shimada K, Kadoguchi T, Akita K, Shiozawa T, Takahashi S, Aikawa T, Ouchi S, Sato Y,Matsushita S, Isoda K, Miyazaki T, Daida H
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他 (金沢)
  • Year and Date: 2017-03-17
• [Presentation] Exacerbated Levels of 1,5-Anhydroglucitol are Associated with Cardiovascular Events in Non-Diabetic Patients after First-Time Elective Percutaneous Coronary Intervention. (2017)
  • Author(s): Takahashi S, Shimada K, Miyauchi K, Ronglung T, Miyazaki T, Shiozawa T, Ouchi S, Aikawa T, Al shahi H, Kadoguchi T, Tamura H, Okazaki S, Isoda K, Daida H
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他 (金沢)
  • Year and Date: 2017-03-17
• [Presentation] Validity of the “Kihon Checklist” as an Index of Frailty and Fatty Acid Levels in Elderly Patients Receiving Cardiac Rehabilitation. (2017)
  • Author(s): 横山美帆, 島田和典, 星野祐里子, 髙橋秀平, 塩澤知之, 相川達郎, 大内翔平, 深尾宏祐, 岩田洋, 宮崎哲朗, 山本平, 天野篤, 代田浩之
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他 (金沢)
  • Year and Date: 2017-03-17
• [Presentation] Polyunsaturated Fatty Acids Levels were Associated with the Occurrence of Asymptomatic Venous Thromboembolism in Patients with Locomotive Syndrome. (2017)
  • Author(s): Shimizu M, Miyazaki T, Sugita Y, Aikawa T, Ouchi S, Hiki M, Shimada K, Daida H.
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他 (金沢)
  • Year and Date: 2017-03-17
• [Presentation] Are Left Atrial Appendage Volume and Plasma Docosahexaenoic Acid Levels Associated with Atrial Fibrillation Recurrence after Catheter Ablation? (2017)
  • Author(s): 塩澤知之, 島田和典, 関田学, 林英守, 田渕晴名, 三浦誠司, 川口裕子, 藤本進一郎, 相川達郎, 大内翔平, 髙橋秀平, 喜多村健一, 杉田有里那, 門口智泰, 宮崎哲朗, 住吉正孝, 中里祐二, 代田浩之
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂他 (金沢)
  • Year and Date: 2017-03-17
• [Presentation] Locomotive症候群患者において多価不飽和脂肪酸は無症候性深部静脈血栓症の発症に関連する (2017)
  • Author(s): 清水 めぐみ, 宮崎 哲朗, 塩澤 淳, 杉田 有里那, 相川 達郎, 大内 翔平, 比企 優, 金子 晴香, 永山 正隆, 石島 旨章, 島田 和典, 金子 和夫, 代田 浩之
  • Organizer: 第49回 日本動脈硬化学会総会・学術集会
• [Presentation] HbA1c7.0%未満の急性冠症候群患者における予後予測に関連する血糖コントロール指標 (2017)
  • Author(s): 大内 翔平, 宮崎 哲朗, 島田 和典, 高橋 秀平, 杉田 有里那, 清水 めぐみ, 加藤 隆生, 相川 達郎, 須田 翔子, 蔡 榮龍, 比企 優, 葛西 隆敏, 宮内 克己, 代田 浩之
  • Organizer: 第49回 日本動脈硬化学会総会・学術集会
• [Presentation] Vitamin D低値はomega-3脂肪酸および炎症と関連し急性心疾患患者の長期予後に影響する (2017)
  • Author(s): 相川 達郎, 宮崎 哲朗, 杉田 有里那, 國本 充洋, 清水 めぐみ, 大内 翔平, 門口 智泰, 塩澤 知之, 比企 優, 高橋 秀平, 島田 和典, 代田 浩之
  • Organizer: 第65回 日本心臓病学会学術集会総会・学術集会
• [Presentation] 急性期心血管疾患患者において血清コエンザイムQ10値は長期予後と相関する (2017)
  • Author(s): 清水 めぐみ, 宮崎 哲朗, 杉田 有里那, 大内 翔平, 相川 達郎, 比企 優, 島田 和典, 代田 浩之
  • Organizer: 第65回 日本心臓病学会学術集会
• [Presentation] 急性心不全患者の長期予後に対するGNRIと多価不飽和脂肪酸の臨床的意義の検討 (2017)
  • Author(s): 大内 翔平, 宮崎 哲朗, 島田 和典, 杉田 有里那, 清水 めぐみ, 加藤 隆生, 相川 達郎, 須田 翔子, 塩澤 知之, 比企 優, 高橋 秀平, 葛西 隆敏, 岩田 洋, 宮内 克己, 代田 浩之
  • Organizer: 第65回 日本心臓病学会学術集会
• [Presentation] 急性心不全患者の予後における微量栄養素の重要性 (2017)
  • Author(s): 宮﨑哲朗、島田和典、大内祥平、相川達郎、清水めぐみ、高橋秀平、代田浩之
  • Organizer: 第54回 日本臨床生理学会総会
• [Presentation] Low preoperative eicosapentaenoic acid levels predict a new onset of deep vein thrombosis after total knee arthroplasty (2017)
  • Author(s): Shimizu M, Miyazaki T, Shiozawa J, Sugita Y, Aikawa T, Ouchi S, Hiki M, Kaneko H, Nagayama M, Ishijima M, Shimada K, Kaneko K, Daida H
  • Organizer: American heart association 2017
  • Int'l Joint Research
• [Presentation] Low levels of 1,5-anhydroglucitol are associated with long-term cardiac mortality in acute coronary syndrome patients with HbA1c levels less than 7.0% (2017)
  • Author(s): Ouchi S, Shimada K, Miyazaki T, Takahashi S, Sugita Y, Shimizu M, Kato T, Aikawa T, Suda S, Sai E, Hiki M, Iwata H, Kasai T, Miyauchi K, Daida H
  • Organizer: American heart association 2017
  • Int'l Joint Research
• [Presentation] Low polyunsaturated fatty acids levels predict long-term mortality in patients with acute decompensated heart failure independent of the Geriatric Nutritional Risk Index (2017)
  • Author(s): Aikawa T, Miyazaki T, Shimada K, Sugita Y, Shimizu M, Kato T, Ouchi S, Suda S, Hiki M, Takahashi S, Iwata H, Kasai T, Miyauchi K, Daida H
  • Organizer: American heart association 2017
  • Int'l Joint Research
• [Presentation] Atrial fibrillation recurrence after catheter ablation is associated with left atrial appendage volume and plasma docosahexaenoic acid levels. (2016)
  • Author(s): Shiozawa T, Shimada K, Sekita G, Miura S, Tabuchi H, Hayashi H, Al Shahi H, Kadoguchi T, Sugita Y, Ouchi S, Aikawa T, Takahashi T, Miyazaki T, Fujimoto S, Sumiyoshi M, Nakazato Y, Daida H
  • Organizer: AHA Scientific Session 2016
  • Place of Presentation: Ernest N. Morial Convention Center (ニューオリンズ、米国)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Decreased circulating omega-6 fatty acid levels are associated with total mortality in patients admitted to cardiac intensive care unit. (2016)
  • Author(s): Ouchi S, Miyazaki T, Shimada K, Sugita Y, Shimizu M, Murata A, Kato T, Aikawa T, Suda S, Shiozawa T, Hiki M, Takahashi S, Kasai T, Miyauchi K, Daida H
  • Organizer: AHA Scientific Session 2016
  • Place of Presentation: Ernest N. Morial Convention Center (ニューオリンズ、米国)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Inhibition of NAD(P)H Oxidase 4 Ameliorates Angiotensin II-Induced Protein Degradation via Improving Mitochondrial Dysfunction in Skeletal Myocytes. (2016)
  • Author(s): Kadoguchi T, Shimada K, Shiozawa T, Takahashi S, Al Shahi H, Aikawa T, Ouchi S, Sugita Y, Miyazaki T, Akita K, Isoda K, Daida H
  • Organizer: AHA Scientific Session 2016
  • Place of Presentation: Ernest N. Morial Convention Center (ニューオリンズ、米国)
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Circadian Rhythm Associated with the Onset of Clinical Scenario 1 (CS1) Acute Decompensated Heart Failure (ADHF). (2016)
  • Author(s): 211.比企優, 岩田洋, 高須清, 谷津翔一郎, 村田梓, 加藤隆生, 須田翔子, 葛西隆敏, 宮崎哲朗, 代田浩之
  • Organizer: 第20回日本心不全学会学術集会
  • Place of Presentation: ロイトン札幌・ホテルさっぽろ芸文館 (札幌)
  • Year and Date: 2016-10-07
• [Presentation] Impact of Worsening Renal Function During Hospitalization on Long-Term Clinical Outcome in Patients with Acute Decompensated Heart Failure. (2016)
  • Author(s): 比企優, 葛西隆敏, 松本紘毅, 村田梓, 加藤隆生, 須田翔子, 宮崎哲朗, 髙木篤俊, 代田浩之
  • Organizer: 第20回日本心不全学会学術集会
  • Place of Presentation: ロイトン札幌・ホテルさっぽろ芸文館 (札幌)
  • Year and Date: 2016-10-07
• [Presentation] NAD(P)H oxidase 4 Activation via Angiotensin II induces Protein Degradation in Skeletal Myocytes. (2016)
  • Author(s): 門口智泰, 島田和典, 塩澤知之, 髙橋秀平, Hamad Al shahi, 駒野悠太, 宮崎哲朗, 秋田耕嗣, 磯田菊生, 代田浩之
  • Organizer: 第20回日本心不全学会学術集会
  • Place of Presentation: ロイトン札幌・ホテルさっぽろ芸文館 (札幌)
  • Year and Date: 2016-10-07
• [Presentation] 当院CCUに入室した急性心不全患者における血中多価不飽和脂肪酸値の検討. (2016)
  • Author(s): 大内翔平, 宮崎哲朗, 島田和典, 杉田有里那, 清水めぐみ, 村田梓, 加藤隆生, 相川達郎, 須田翔子, 塩澤知之, 比企優, 高橋秀平, 葛西隆敏, 宮内克己, 代田浩之
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム (東京)
  • Year and Date: 2016-09-23
• [Presentation] 急性非代償性心不全患者における入院期間中のworsening renal functionの長期予後への影響. (2016)
  • Author(s): 比企優, 葛西隆敏, 加藤隆生, 須田翔子, 松本紘毅, 村田梓, 宮崎哲朗, 髙木篤俊, 代田浩之
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム (東京)
  • Year and Date: 2016-09-23
• [Presentation] アンジオテンシンIIに依存した酸化ストレスは骨格筋タンパク分解を引き起こす. (2016)
  • Author(s): 門口知泰, 島田和典, 塩澤知之, 高橋秀平, Hamad Al Shahi, 大内翔平, 相川達郎, 秋田耕嗣, 磯田菊生, 宮崎哲朗, 代田浩之
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム (東京)
  • Year and Date: 2016-09-23
• [Presentation] 術前血中EPA低値は人工膝関節全置換術後の深部静脈血栓症発症と関連する. (2016)
  • Author(s): 206.宮崎哲朗, 清水めぐみ, 塩澤淳, 杉田有里那, 木下真由子, 羽田晋之介, 相川達郎, 大内翔平, 比企優, 金子晴香, 永山正隆, 劉立足, 石島旨章, 島田和典, 金子和夫, 代田浩之
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム (東京)
  • Year and Date: 2016-09-23
• [Presentation] 血中多価不飽和脂肪酸濃度と腹部大動脈瘤最大短径ならびにその進展速度との関連. (2016)
  • Author(s): 相川達郎, 宮崎哲朗, 島田和典, 杉田有里那, 清水めぐみ, 大内翔平, 門口智泰, 塩澤知之, 比企優, 髙橋秀平, 土肥静之, 天野篤, 代田浩之
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム (東京)
  • Year and Date: 2016-09-23
• [Presentation] 経皮的冠動脈形成術施行患者における血清1,5-anhydroglucitol測定の意義. (2016)
  • Author(s): 髙橋秀平, 島田和典, 宮内克己, 蔡榮龍, 宮崎哲朗, 塩澤知之, 大内翔平, 相川達郎, Hamad Al Shahi, 門口智泰, 田村浩, 岡崎真也, 磯田菊生, 代田浩之
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム (東京)
  • Year and Date: 2016-09-23
• [Presentation] 心房細動アブレーション患者における血漿中DHAと左心耳容積の関連. (2016)
  • Author(s): 塩澤知之, 島田和典, 関田学, 三浦誠司, 小松さやか, 田淵晴名, 林英守, 門口知泰, 髙橋秀平, 大内翔平, 相川達郎, 宮崎哲朗, 住吉正孝, 中里祐二, 代田浩之
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム (東京)
  • Year and Date: 2016-09-12
• [Presentation] Are low DHA levels associated with left atrial appendage volume and atrial fibrillation recurrence after catheter ablation? (2016)
  • Author(s): Shiozawa T, Shimada K, Sekita G, Miura S, Tabuchi H, Hayashi H, Al Shahi H, Kadoguchi T, Sugita Y, Ouchi S, Aikawa T, Takahashi T, Miyazaki T, Fujimoto S, Sumiyoshi M, Nakazato Y, Daida H
  • Organizer: ESC Congress 2016
  • Place of Presentation: Fiera di Roma (ローマ、イタリア)
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] NAD(P)H oxidase 4 plays a key role in Angiotensin II-induced protein degradation in skeletal muscle cells. (2016)
  • Author(s): Kadoguchi T, Shimada K, Shiozawa T, Takahashi S, Al Shahi H, Aikawa T, Ouchi S, Sugita Y, Miyazaki T, Akita K, Isoda K, Daida H
  • Organizer: ESC Congress 2016
  • Place of Presentation: Fiera di Roma (ローマ、イタリア)
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] 経皮的冠動脈形成術施行患者における血清1,5-anhydroglucitol低下と心血管イベントとの関連. (2016)
  • Author(s): 喜多村健一, 島田和典, 高橋秀平, 宮内克己, 蔡榮龍, 宮崎哲朗, 塩澤知之,大内翔平, 相川達郎, Hamas Al Shahi, 門口智泰, 田村浩, 岡崎真也, 磯田菊生, 代田浩之
  • Organizer: 第48回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル (東京)
  • Year and Date: 2016-07-14
• [Presentation] 血中多価不飽和脂肪酸濃度と腹部大動脈瘤との関連. (2016)
  • Author(s): 相川達郎, 宮崎哲朗, 島田和典, 杉田有里那, 清水めぐみ, 大内翔平, 門口智泰, 塩澤知之, 比企優, 髙橋秀平, 土肥静之, 天野篤, 代田浩之
  • Organizer: 第48回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル (東京)
  • Year and Date: 2016-07-14
• [Presentation] 骨格筋タンパク合成および分解調節におけるNAD(P)H oxidase4の役割の検討. (2016)
  • Author(s): 200.門口智泰, 島田和典, 塩澤知之, 髙橋秀平, Hamad Al Shahi, 大内翔平, 相川達郎, 秋田耕嗣, 宮崎哲朗, 磯田菊生, 代田浩之
  • Organizer: 第48回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル (東京)
  • Year and Date: 2016-07-14
• [Presentation] Decreased circulating omega-6 fatty acid levels are associated with total mortality in patients admitted to cardiac intensive care unit. (2016)
  • Author(s): Kadoguchi T, Shimada K, Shiozawa T, Takahashi S, Al Shahi H, Aikawa T, Ouchi S, Sugita Y, Miyazaki T, Akita K, Isoda K, Daida H
  • Organizer: ESC Congress 2016
  • Place of Presentation: Fiera di Roma (ローマ、イタリア)
  • Int'l Joint Research
• [Presentation] 急性非代償性心不全患者における血中カルニチン濃度の臨床的意義 (2015)
  • Author(s): 宮﨑哲朗、高橋 秀平、島田 和典、上野 剛、加藤 隆生、須田 翔子、比企 優、松森 理枝、葛西 隆敏、高木 篤俊、宮内 克己、三井田 孝、代田 浩之
  • Organizer: 第63回 日本心臓病学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-09-19