| Project/Area Number |
15K01278
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAGAI Akiko 東京医科歯科大学, 生体材料工学研究所, 准教授 (40360599)
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| Co-Investigator(Kenkyū-buntansha) |
野崎 浩佑 東京医科歯科大学, 生体材料工学研究所, 助教 (00507767)
堀内 尚紘 東京医科歯科大学, 生体材料工学研究所, 助教 (90598195)
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| Research Collaborator |
MASUDA Hiroshi 久留米大学, 医学部, 准教授 (10321861)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 機能性骨補填材 / アパタイトナノ薄膜 / リアルタイムイメージング / 機能性骨補填剤 / 材料表面設計 / リアルタイム評価 / 経時的イメージング / アパタイト / 薄膜 / ライブイメージング / 骨芽細胞 / 骨組織 |
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| Outline of Final Research Achievements |
In this study, we aimed to evaluate interactions between the living body and implant materials by real-time imaging to develop functional bone substitutes.
Hydroxyapatite nanoparticles were prepared using self-organization of organic molecule. Nano-thin film was formed on glass, and stem cells or osteoblasts were cultured on it. Cell behaviors such as cell attachments or endocytosis could observed in real-time.
Real-time imaging for interactions between bone tissues and implants (hydroxyapatite porous bodies) were observed using the cranial window method. Bone formation started around the damaged bone with lacking in material-side by confocal microscopy observations. The result linked the difference between a bone prosthetic material and an autologous bone in the repair of bone and suggested the idea of development for innovative materials.
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