Development of the early diaganosis and treatment for discogenic low back pain
| Project/Area Number |
15K01337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Iwate Medical University |
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Principal Investigator |
Doita Minoru 岩手医科大学, 医学部, 教授 (60237170)
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| Co-Investigator(Kenkyū-buntansha) |
村上 秀樹 岩手医科大学, 医学部, 准教授 (20285604)
遠藤 寛興 岩手医科大学, 医学部, 講師 (60458172)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 椎間板 / 髄核 / MRI / T2マッピング / 変性 / 椎間関節 / 側方椎体間固定術 / 最少侵襲手術 / フッ素 / 側方椎体間固定 / T2 mapping |
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| Outline of Final Research Achievements |
We tried to develop the early diagnosis and treatment for discogenic low back pain. There was a significant decrease in the water content of facet joints and the NP at every lumbar spinal level after dynamic loading by physical lumbar exercise. These changes appear to play an important and interactional role in the maintenance of the interstitial matrix in the IVD NP and cartilage in the facet joint. It revealed that it will be necessary for development of the treatment method without interbody fusion technique at the lumbar spine for discogenic low back pain.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Functional impact of integrin α5β1 on the homeostasis of intervertebral discs: a study of mechanotransduction pathways using a novel dynamic loading organ culture system2015
Author(s)
Kurakawa T, Kakutani K, Morita Y, Kato Y, Yurube T, Hirata H, Miyazaki S, Terashima Y, Maeno K, Takada T, Doita M, Kurosaka M, Inoue N, Masuda K, Nishida K
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Journal Title
Spine J
Volume: 15
Pages: 417-26
Related Report
Peer Reviewed / Acknowledgement Compliant
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