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Therapeutic and preventive effects and mechanisms of exercise training on renal disorder of salt-sensitive hypertension

Research Project

Project/Area Number 15K01360
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionTeikyo University (2016-2018)
Tohoku University (2015)

Principal Investigator

Ogawa Yoshiko  帝京大学, 医療技術学部, 助教 (90733791)

Co-Investigator(Kenkyū-buntansha) 伊藤 修  東北大学, 医学系研究科, 大学院非常勤講師 (00361072)
森 信芳  東北大学, 医学系研究科, 非常勤講師 (50463790)
上月 正博  東北大学, 医学系研究科, 教授 (70234698)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords食塩感受性高血圧 / Dahl食塩感受性ラット / 運動 / 腎保護作用 / 高血圧予防 / 酸化ストレス / 一酸化窒素
Outline of Final Research Achievements

The aim of the study was to investigate the therapeutic and preventive effects and mechanisms of exercise training on salt-sensitive hypertension and concomitant renal disorder. In Dahl salt-sensitive rats, which are model animals of salt-sensitive hypertension, treadmill running for 8 weeks significantly improved proteinuria and glomerulosclerosis without changing blood pressure when salt loading and exercise training were performed simultaneously. When exercise training was performed prior to salt loading, exercise training significantly improved the development of salt-sensitive hypertension and concomitant renal disorder. Renal oxidative stress caused by salt loading was significantly reduced in the kidneys of rats with exercise training. These results suggest that exercise training have the therapeutic and preventive effects on salt-sensitive hypertension and concomitant renal disorder, and improvements in oxidative stress influence the renoprotective effects of exercise training.

Academic Significance and Societal Importance of the Research Achievements

本研究では長期的な運動が食塩感受性高血圧とそれに伴う腎障害に対して治療的・予防的効果を持つことと、これらの効果には長期的な運動による腎臓内の酸化ストレスの軽減が関与していることが明らかとなった。慢性腎臓病(CKD)の腎障害そのものに対する運動の効果が十分に解明されているとは言い難い現状において、本研究の結果は腎障害に対する長期的な運動の効果の理論的根拠となるものであり、腎臓リハビリの確立や普及、適応の拡大につながるものである。腎臓リハビリが普及すれば、より多くのCKD患者がその恩恵を享受できるだけでなく、CKD患者の透析導入時期を遅らせることにより医療経済的にも大きな利益をもたらすと考える。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2018 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] 食塩感受性ラットにおける長期的運動の腎保護作用-酸化ストレスとNOの観点から2015

    • Author(s)
      坂田佳子
    • Journal Title

      東北医学会雑誌

      Volume: 127 Pages: 51-51

    • Related Report
      2015 Research-status Report
  • [Journal Article] Dahl食塩感受性ラットの腎レニンーアンジオテンシン系への長期的運動の効果2015

    • Author(s)
      作山晃裕, 伊藤 修, 坂田佳子, 戎 栄, 上月正博
    • Journal Title

      運動器リハビリテーション

      Volume: 26 Pages: 87-94

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Dahl食塩感受性ラットの腎障害に対する長期的運動の効果 CYP4A/20-HETE系に関する検討2018

    • Author(s)
      高橋淳太、小川佳子、作山晃裕、室谷嘉一、森信芳、上月正博、伊藤修
    • Organizer
      第43回日本運動療法学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高血圧発症前からの運動が食塩感受性高血圧と腎障害へ及ぼす影響2016

    • Author(s)
      小松美和、小川佳子,作山晃裕,胡 丐尊,三浦平寛,伊藤 修,上月正博
    • Organizer
      第6回日本腎臓リハビリテーション学会学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 高血圧発症以前からの運動が食塩感受性高血圧とそれに伴う腎障害の進展に及ぼす影響2015

    • Author(s)
      小松美和, 小川佳子,作山晃裕,胡 丐尊,三浦平寛,伊藤 修,上月正博
    • Organizer
      第38回日本リハビリテーション医学会東北地方会
    • Place of Presentation
      八戸地域地場産業振興センター(八戸)
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of exercise training on renin-angiotensin system in the kidney of Dahl salt-sensitive rats2015

    • Author(s)
      Sakuyama A, Ito O, Sakata Y, Hu G, Suda C, Kohzuki M
    • Organizer
      American Heart Association High Blood Pressure Research 2015 Scientific Sessions
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2015-09-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dahl食塩感受性高血圧ラットへの長期的運動が腎renin-angiotensin系へ及ぼす影響2015

    • Author(s)
      山晃裕、伊藤修、小川佳子、小松美和、胡丐尊、三浦平寛、須田千尋、上月正博
    • Organizer
      第34回日本臨床運動療法学会
    • Place of Presentation
      東北大学医学部艮陵会館(仙台)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Effects of exercise training on renal function and the cytochrome P-450 4A metabolism of arachidonic acid in the kidney of salt-sensitive hypertensive rats.2015

    • Author(s)
      Sakata Y, Ito O, Kohzuki M.
    • Organizer
      9th World Congress of the International Society of Physical and Rehabilitation Medicine
    • Place of Presentation
      Berlin, Germany
    • Year and Date
      2015-06-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dahl食塩感受性高血圧ラットの腎レニン・アンジオテンシン系への長期的運動の影響2015

    • Author(s)
      伊藤 修, 坂田佳子, 森 信芳, 上月正博.
    • Organizer
      第52回日本リハビリテーション医学会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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