Effects of skeletal muscle ischemic preconditioning for fatigability and damage protection

• Project/Area Number: 15K01625
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Hokusho University
• Principal Investigator: OKITA KOICHI 北翔大学, 生涯スポーツ学部, 教授 (80382539)
• Co-Investigator(Kenkyū-buntansha): 絹川 真太郎 北海道大学, 医学研究院, 講師 (60399871) ; 横田 卓 北海道大学, 医学研究院, 助教 (90374321)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 骨格筋 / 虚血再灌流 / トレーニング / 疲労 / 運動能力 / 虚血プレコンディショニング / プレコンディショニング / 虚血 / 血流制限 / 運動トレーニング / バイオマーカー / マイオカイン

Outline of Final Research Achievements

First, we examined the effective repetition numbers (from zero to four) of direct and remote ischemic preconditioning in lower leg on exercise performance and fatigability. Contrary to previous reports, the results showed that any repetition of IPC did not affect the maximum strength and fatigability in knee extension. We reported those preliminary results at annual meeting of the Japanese Society of Physical Fitness and Sports Medicine (2016, 2017). Concerning those negative results, we examined effects of IPC in a practical exercise of repeated-jump and combined IPC with dietary nitrate (donor of nitric oxide). However, we could not demonstrate significant effects of IPC on exercise performance and muscle damage even with dietary nitrate (annual meeting of Japanese Association of Exercise Therapy and Prevention, JACR 2017). We are preparing to present the summaries of those results at annual scientific meetings and to submit them to international journals.

Research Products

• [Journal Article] Modeling relationships of achievement motivation and physical fitness with academic performance in Japanese schoolchildren: Moderation by gender (2018)
  • Author(s): Ishihara, T., Morita, N., Nakajima, T., Okita, K., Sagawa, M., & Yamatsu, K.
  • Journal Title: Physiology & Behavior Volume: 194 Pages: 66-72
  • DOI: 10.1016/j.physbeh.2018.04.031
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Direct and indirect relationships of physical fitness, weight status, and learning duration to academic performance in Japanese schoolchildren (2018)
  • Author(s): Ishihara T, Morita N, Nakajima T, Okita K, Yamatsu K, Sagawa M.
  • Journal Title: European Journal of Sport Science. Volume: 18(2) Pages: 286-294
  • DOI: 10.1080/17461391.2017.1409273
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Deletion of NAD(P)H oxidase 2 prevents angiotensin II-induced skeletal muscle atrophy. (2018)
  • Author(s): Kadoguchi Tomoyasu、Takada Shingo、Yokota Takashi、Furihata Takaaki、Matsumoto Junichi、Tsuda Masaya、Mizushima Wataru、Fukushima Arata、Okita Koichi、Kinugawa Shintaro
  • Journal Title: BioMed Res Int Volume: 2018 Pages: 1-10
  • DOI: 10.1155/2018/3194917
  • NAID: 120006406686
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 運動機能とリハビリにおけるグアニジノ化合物 (2017)
  • Author(s): 沖田 孝一
  • Journal Title: 腎と透析 Volume: 83, 別冊 Pages: 85-90
• [Journal Article] 骨格筋：as a master regulator for health and disease－各種疾患にみる骨格筋障害・萎縮－ (2017)
  • Author(s): 沖田 孝一
  • Journal Title: 臨床スポーツ医学-OPINION Volume: 34 Pages: 632-633
• [Journal Article] Arm-cranking Exercise Training Reduces Plasminogen Activator Inhibitor 1 in People with Spinal Cord Injury. (2017)
  • Author(s): Horiuchi M, Okita K
  • Journal Title: Arch Phys Med Rehabil. Volume: 17 Pages: 30141-7
  • DOI: 10.1016/j.apmr.2017.02.007
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Pioglitazone improves whole-body aerobic capacity and skeletal muscle energy metabolism in patients with metabolic syndrome. (2017)
  • Author(s): Yokota T, Kinugawa S, Hirabayashi K, Suga T, Takada S, Omokawa M, Kadoguchi T, Takahashi M, Fukushima A, Matsushima S, Yamato M, Okita K, Tsutsui H
  • Journal Title: J Diabetes Investig. Volume: 印刷中 Pages: 535-541
  • DOI: 10.1111/jdi.12606
  • NAID: 120006337767
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inverse Relationship between Sleep Duration and Cardio-Ankle Vascular Index in Children (2017)
  • Author(s): Morita N, Kambayashi I, Okuda T, Oda S, Takada S, Nakajima T, Shide N, Shinkaiya H, Okita K.
  • Journal Title: J Atheroscler Thromb Volume: 印刷中 Issue: 8 Pages: 1-6
  • DOI: 10.5551/jat.36517
  • NAID: 130005876106
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure. (2017)
  • Author(s): Kimura K
  • Journal Title: Int J Cardiol. Volume: in press Pages: 239-246
  • NAID: 120006347185
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling. (2016)
  • Author(s): Takada S, Masaki Y, Kinugawa S, Matsumoto J, Furihata T, Mizushima W, Kadoguchi T, Fukushima A, Homma T, Takahashi M, Harashima S, Matsushima S, Yokota T, Tanaka S, Okita K, Tsutsui H
  • Journal Title: Cardiovasc Res. Volume: 111 Pages: 338-347
  • DOI: 10.1093/cvr/cvw182
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 糖尿病患者における筋機能異常 (2016)
  • Author(s): 沖田孝一、髙田真吾、横田 卓、絹川真太郎
  • Journal Title: 理学療法学 Volume: 43理学療法学 Pages: 95-95
  • Acknowledgement Compliant
• [Journal Article] 心不全における骨格筋萎縮予防 (2016)
  • Author(s): 沖田孝一、髙田真吾、横田 卓、絹川真太郎
  • Journal Title: 日本心臓リハビリテーション学会誌 Volume: 22 Pages: 132-135
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 知りたい！フレイル患者さんの運動療法 (2016)
  • Author(s): 沖田孝一、髙田真吾、阿部隆宏、米澤一也
  • Journal Title: HEART nursing Volume: 29 Pages: 99-103
  • Acknowledgement Compliant
• [Journal Article] 運動の臓器連関と未病対策：心疾患における運動の意義 (2016)
  • Author(s): 髙田真吾、沖田孝一
  • Journal Title: 運動の臓器連関と未病対策 心疾患における運動の意義 Volume: 22 Pages: 1347-5541
  • Acknowledgement Compliant
• [Journal Article] 運動による筋肉の酸素利用効率の改善 (2016)
  • Author(s): 沖田孝一、髙田真吾
  • Journal Title: 腎と透析 Volume: 80 Pages: 636-640
  • Acknowledgement Compliant
• [Journal Article] Low-intensity exercise under ischemic conditions enhances metabolic stress in patients with heart failure. (2015)
  • Author(s): Takahashi M, Kinugawa S, Takada S, Hirabayashi K, Yokota T, Matsushima S, Saito A, Okita K, Tsutsui H
  • Journal Title: Int J Cardiol Volume: 201 Pages: 142-144
  • DOI: 10.1016/j.ijcard.2015.08.022
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Skeletal Muscle Abnormalities in Heart Failure (2015)
  • Author(s): Kinugawa S, Takada S, Matsushima S, Okita K, Tsutsui H
  • Journal Title: Int. Heart J. Volume: 56 Issue: 5 Pages: 1319-1330
  • DOI: 10.1536/ihj.15-108
  • NAID: 130005102118
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Sesamin prevents decline in exercise capacity and impairment of skeletal muscle mitochondrial function in mice with high-fat diet-induced diabetes. (2015)
  • Author(s): Takada S, Kinugawa S, Matsushima S, Takemoto D, Furihata T, Mizushima W, Fukushima A, Yokota T, Ono Y, Shibata H, Okita K, Tsutsui H
  • Journal Title: Exp Physiol Volume: 100 Pages: 1319-1330
  • DOI: 10.1113/ep085251
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Mitochondrial Proteins Alters Fatty Acid β-Oxidation in Skeletal Muscle and Limits Exercise Capacity in Post-Infarct Heart Failure in Mice (2017)
  • Author(s): Masaya Tsuda, Arata Fukushima, Junichi Matsumoto, Shingo Takada, Takashi Yokota, Takaaki Furihata, Takashi Katayama, Takayuki Nakajima, Hideo Nambu, Satoshi Maekawa, Ryosuke Shirakawa, Naoya Kakutani, Yoshikuni Obata, Katsuma Yamanashi, Koichi Okita, Shintaro Kinugawa
  • Organizer: American Heart Association Scientific Session 2017
  • Int'l Joint Research
• [Presentation] High Respiratory Exchange Ratio at Submaximal Exercise Level Predicts Adverse Clinical Outcomes in Patients With Heart Failure (2017)
  • Author(s): Naoya Kakutani, Arata Fukushima, Takashi Yokota, Takashi Katayama, Ryosuke Shirakawa, Satoshi Maekawa, Hideo Nambu, Takahiro Abe, Takaaki Furihata, Junichi Matsumoto, Masaya Tsuda, Takayuki Nakajima, Katsuma Yamanashi, Yoshikuni Obata, Shingo Takada, Akimichi Saito, Koichi Okita.
  • Organizer: American Heart Association Scientific Session 2017
  • Int'l Joint Research
• [Presentation] Health condition, lifestyle and cognitive function classified by exercise behavior among community-dwelling older people in northern Japan (2017)
  • Author(s): Sasaki H, Kozakai R, Ueda T, Ide K, Hanai A, Oda, S, Homma M, Kuroda Y, Honda, R, Ogawa H, Odajima M, Aiuchi T, Okita K.
  • Organizer: The 22th annual congress of ECSS
  • Int'l Joint Research
• [Presentation] Relationship of cognitive decline with social activity, regular exercise and physical performance among community-dwelling older people in northern Japan (2017)
  • Author(s): Kozakai R, Ueda T, Sasaki H, Ide K, Hanai A, Oda S, Homma M, Kuroda Y, Honda R, Ogawa H, Odajima M, Aiuchi T, Okita K.
  • Organizer: The 22th annual congress of ECSS
  • Int'l Joint Research
• [Presentation] 中学生部活動および体力と学業成績の関連 (2017)
  • Author(s): 石原 暢、中島 寿宏、山津幸司、沖田孝一、水野眞佐夫、佐川正人、森田憲輝
  • Organizer: 第72回日本体力医学会大会
• [Presentation] 骨格筋の虚血プレコンディショニングは運動能力を向上させるのか？ (2017)
  • Author(s): 幡谷若奈、熊谷 礼、高田真吾、森田憲輝、沖田孝一
  • Organizer: 第72回日本体力医学会大会
• [Presentation] 嫌気性代謝閾値におけるガス交換比の上昇は心不全患者の独立した予後規定因子である (2017)
  • Author(s): 角谷尚哉、福島 新、横田 卓、高田真吾、沖田孝一、絹川真太郎
  • Organizer: 第72回日本体力医学会大会
• [Presentation] 心不全の骨格筋異常におけるミトコンドリアアセチル化の役割 (2017)
  • Author(s): 高田真吾、津田正哉、福島 新、角谷尚哉、横田 卓、沖田孝一、絹川真太郎
  • Organizer: 第72回日本体力医学会大会
• [Presentation] 間欠的スプリント運動を課題としたフィールドテストの考案 (2017)
  • Author(s): 吉田昌弘、中島千佳、角谷尚哉、吉田 真、沖田孝一
  • Organizer: 第72回日本体力医学会大会
• [Presentation] 北海道在宅高年齢者における自宅近隣施設環境と運動習慣との関連 (2017)
  • Author(s): 小川裕美、小坂井留美、上田知行、佐々木浩子、井出幸二郎、花井篤子、小田史郎、黒田裕太、本間美幸、本多理沙、小田嶋政子、相内俊一、沖田孝一
  • Organizer: 第72回日本体力医学会大会
• [Presentation] 北海道在宅高年齢者における自宅近隣施設環境と社会活動性との関連 (2017)
  • Author(s): 小坂井留美、上田知行、井出幸二郎、小田史郎、本多理紗、小田嶋政子、相内俊一、沖田孝一
  • Organizer: 第72回日本体力医学会大会
• [Presentation] 食事性硝酸塩投与による大腿筋群パフォーマンス向上効果の検討 (2017)
  • Author(s): 熊谷 礼、沖田孝一、幡谷若奈、高田真吾、森田憲輝
  • Organizer: 第36回日本臨床運動療法学会学術集会
• [Presentation] 虚血プレコンディショニングは骨格筋機能を改善するか？ (2017)
  • Author(s): 沖田孝一
  • Organizer: 第23回日本心臓リハビリテーション学会学術集会（シンポジウム）
  • Invited
• [Presentation] 骨格筋機能改善薬 (2017)
  • Author(s): 沖田孝一 、高田真吾、横田 卓、絹川真太郎
  • Organizer: 第23回日本心臓リハビリテーション学会学術集会（シンポジウム）
  • Invited
• [Presentation] Brain-derived neurotrophic factor plays an important role of exercise capacity and mitochondrial function in the skeletal muscle in mice with post-infarct heart failure. (2016)
  • Author(s): Nakajima T, Kinugawa S, Matsumoto J, Takada S, Furihata T, Tsuda M, Katayama T, Nambu H, Shirakawa R, Maekawa S, Kakutani N, Mizushima W, Yokota T, Okita K, Tsutsui H.
  • Organizer: American Heart Association Scientific Session 2016.
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] The activation of glucagon-like peptide-1 improves the mitochondrial abnormalities in skeletal muscle and exercise intolerance in heart failure mice. (2016)
  • Author(s): Katayama T, Takada S, Masaki Y, Kinugawa S, Matsumoto J, Nakajima T, Tsuda M, Furihata T, Mizushima W, Fukushima A, Yokota T, Okita K, Tsutsui H.
  • Organizer: American Heart Association Scientific Session 2016.
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Mitochondrial protein acetylation in skeletal muscle was associated with exercise intolerance in heart failure after myocardial infarction. (2016)
  • Author(s): Tsuda M, Kinugawa S, Takada S, Fukushima A, Yokota T, Mizushima W, Furihata T, Matsumoto J, Katayama T, Nakajima T, Maekawa S, Nambu H, Shirakawa R, Kakutani N, Okita K, Tsutsui H.
  • Organizer: American Heart Association Scientific Session 2016.
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] The activation of Glucagon-like Peptide-1 Improves the Mitochondrial Abnormalities in Skeletal Muscle and Exercise Intolerance in Heart Failure Mice. (2016)
  • Author(s): Takahashi KATAYAMA, Shingo TAKADA, Yoshihiro MASAKI, Shintaro KINUGAWA, Junichi MATSUMOTO, Takaaki FURIHATA, Arata FUKUSHIMA, Takashi YOKOTA, Koichi OKITA, Hiroyuki TSUTSUI.
  • Organizer: 第20回日本心不全学会学術集会2016
  • Place of Presentation: ロイトン札幌・ホテル札幌芸文館，北海道
  • Year and Date: 2016-10-07
• [Presentation] Analysis of Expired Gas During the Hemodialysis in Patients with Cardiovascular Disease. (2016)
  • Author(s): Motoki NAKAO, Masashige TAKAHASHI, Kou MOTOI, Hikaru HAGIWARA, Yoshikuni OBATA, Hidetsugu SAKAI, Shintaro KINUGAWA, Koichi OKITA.
  • Organizer: 第20回日本心不全学会学術集会2016
  • Place of Presentation: ロイトン札幌・ホテル札幌芸文館，北海道
  • Year and Date: 2016-10-07
• [Presentation] Pioglitazone Improves Aerobic Capacity and Skeletal Muscle Energy Metabolism in Patients with Metabolic Syndrome. (2016)
  • Author(s): Takashi YOKOTA, Shintaro KINUGAWA, Kagami HIRABAYASHI, Tadashi SUGA, Shingo TAKADA, Koichi OKITA, Hiroyuki TSUTSUI.
  • Organizer: 第20回日本心不全学会学術集会2016
  • Place of Presentation: ロイトン札幌・ホテル札幌芸文館，北海道
  • Year and Date: 2016-10-07
• [Presentation] mitoNEET蛋白はミトコンドリアの鉄恒常性を調整する (2016)
  • Author(s): 高田真吾、隆旗高明、横田 卓、沖田孝一
  • Organizer: 第71回日本体力医学会大会
  • Place of Presentation: 岩手県民情報交流センター（アイーナ），岩手県
  • Year and Date: 2016-09-23
• [Presentation] 北海道在宅高年齢者における非運動実践と社会的孤立との関連 (2016)
  • Author(s): 小坂井留美、上田知行、佐々木浩子、井出幸二郎、花井篤子、小田史郎、本間美幸、小田嶋政子、本多理紗、相内俊一、沖田孝一
  • Organizer: 第71回日本体力医学会大会
  • Place of Presentation: 盛岡市民文化ホール（マリオス内），岩手県
  • Year and Date: 2016-09-23
• [Presentation] 骨格筋における直接的虚血プレコンディショニングが最大筋力へ与える影響 (2016)
  • Author(s): 田尾賢吾、沖田孝一、熊谷 礼、高田真吾、森田憲輝
  • Organizer: 第71回日本体力医学会大会
  • Place of Presentation: 盛岡市民文化ホール（マリオス内），岩手県
  • Year and Date: 2016-09-23
• [Presentation] 高年齢者における運動実施状況の違いによる健康状態，睡眠と食品摂取状況 (2016)
  • Author(s): 佐々木浩子、上田知行、小坂井留美、井出幸二郎、小田史郎、花井篤子、本間美幸、小田嶋政子、相内俊一、本多理紗、沖田孝一
  • Organizer: 第71回日本体力医学会大会
  • Place of Presentation: 盛岡市民文化ホール（マリオス内），岩手県
  • Year and Date: 2016-09-23
• [Presentation] 糖代謝異常にみられる運動耐容能低下と骨格筋障害について (2016)
  • Author(s): 沖田孝一、高田真吾、横田 卓、絹川真太郎
  • Organizer: 第35回日本臨床運動療法学会学術集会
  • Place of Presentation: 慶應義塾大学日吉キャンパス
  • Year and Date: 2016-09-03
  • Invited
• [Presentation] 肥満者のサルコペニア評価を目的とした 簡易的運動機能測定は付加的な 心血管疾患リスク評価となり得るか？ (2016)
  • Author(s): 熊谷 礼 、沖田孝一、田尾賢吾、森田憲輝
  • Organizer: 第35回日本臨床運動療法学会学術集会
  • Place of Presentation: 慶應義塾大学日吉キャンパス
  • Year and Date: 2016-09-03
• [Presentation] Brain-derived neurotrophic factor improves exercise capacity and mitochondrial function in the skeletal muscle in mice with postinfarct heart failure. (2016)
  • Author(s): Matsumoto J, Takada S, Kinugawa S, Mizushima W, Furihata T, Tsuda T, Nakajima T, Katayama T, Yokota T, Okita K, Tsutsui H.
  • Organizer: European Society of Cardiology 2016
  • Place of Presentation: Roma, Italy
  • Year and Date: 2016-08-27
  • Int'l Joint Research
• [Presentation] アンジオテンシンII誘発性の骨格筋萎縮におけるNAD(P)H oxidase 2の役割の検討. (2016)
  • Author(s): 門口智泰，絹川真太郎，高田真吾，福島新，降旗高明，松本純一，津田正哉，横田卓，松島将士，沖田孝一，筒井裕之
  • Organizer: 第2回日本筋学会学術集会
  • Place of Presentation: 国立精神・神経医療研究センター
  • Year and Date: 2016-08-05
• [Presentation] 心筋梗塞後心不全における骨格筋ミトコンドリア機能および運動能力に対するGLP-1受容体の役割の解明 (2016)
  • Author(s): 高田真吾，正木芳宏，松本純一，門口智泰，横田卓，水島航，降旗高明，津田正哉，中島孝之，片山貴史，福島新，沖田孝一，絹川真太郎
  • Organizer: 第2回日本筋学会学術集会
  • Place of Presentation: 国立精神・神経医療研究センター
  • Year and Date: 2016-08-05
• [Presentation] The role of brain-deraived neurotrophic factor in the skeletal muscle of mice with heart failure (2016)
  • Author(s): 松本純一，高田真吾，絹川真太郎，降旗高明，津田正哉，中島孝之，片山貴史，水島航，横田卓，沖田孝一，筒井裕之
  • Organizer: 第2回日本筋学会学術集会
  • Place of Presentation: 国立精神・神経医療研究センター
  • Year and Date: 2016-08-05
• [Presentation] Brain-Derived Neurotrophic Factor Improves Exercise Capacity in Mice with Heart Failure. (2016)
  • Author(s): Junichi Matsumoto, Shingo Takada, Shintaro Kinugawa, Takashi Yokota, Takaaki Furihata, Masaya Tsuda, Takayuki Nakajima, Takashi Katayama, Koichi Okita, Hiroyuki Tsutsui
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京フォーラム, 東京.
  • Year and Date: 2016-07-16
• [Presentation] 脳由来神経栄養因子（BDNF）は加齢による骨格筋ミトコンドリア機能および運動能力低下を改善する (2016)
  • Author(s): 高田真吾, 絹川真太郎, 横田 卓, 水島 航, 降旗高明, 松本純一, 津田正哉, 中島孝之, 片山貴史, 沖田孝一, 筒井 裕之
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京フォーラム, 東京.
  • Year and Date: 2016-07-16
• [Presentation] 血中代謝産物プロファイリングによる心不全患者の運動耐容能低下機序に関する研究 (2016)
  • Author(s): 津田正哉, 絹川真太郎, 横田 卓, 水島 航, 降旗高明, 高田真吾, 松本純一, 津田正哉, 中島孝之, 片山貴史, 沖田孝一, 筒井 裕之
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京フォーラム, 東京
  • Year and Date: 2016-07-16
• [Presentation] 血液透析合併心血管疾患患者のCPXおよび血液透析中における呼気ガス分析の検討 (2016)
  • Author(s): 中尾元基, 高橋将成, 本居 昂, 萩原 光, 尾畑嘉一, 坂井英世, 絹川真太郎, 沖田孝一
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京フォーラム, 東京
  • Year and Date: 2016-07-16
• [Presentation] MRIを用いた骨格筋評価（one stop shop: 量、代謝、ミトコンドリア機能、細胞内脂肪まで） (2016)
  • Author(s): 沖田孝一
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京フォーラム, 東京
  • Year and Date: 2016-07-16
  • Invited
• [Presentation] 基礎研究を予防心臓病学の未来に活かす (2016)
  • Author(s): 沖田 孝一、高田真吾、横田 卓、絹川真太郎
  • Organizer: 第22回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 東京フォーラム, 東京
  • Year and Date: 2016-07-16
  • Invited
• [Presentation] Effects of 6-month aerobic training in smokers with multiple cardiovascular risk factors. (2016)
  • Author(s): Tao K, Okita K, Takada S, Kumagai A, Morita N.
  • Organizer: ACSM's 63rd Annual Meeting, 7th World Congress on Exercise is Medicine, World Congress on the Basic Science of Energy Balance.
  • Place of Presentation: Boston, Massachusetts, USA.
  • Year and Date: 2016-05-31
  • Int'l Joint Research
• [Presentation] 心不全における骨格筋障害の考え方と対策 (2016)
  • Author(s): 沖田孝一
  • Organizer: 第51回日本心血管理学療法学会
  • Place of Presentation: 札幌コンベンションセンター, 札幌
  • Year and Date: 2016-05-27
  • Invited
• [Presentation] 分子生物学的観点から糖尿病患者の筋機能の可能性を探る (2016)
  • Author(s): 沖田孝一, 高田真吾, 横田 卓, 絹川真太郎
  • Organizer: 日本糖尿病理学療法学会
  • Place of Presentation: 札幌コンベンションセンター, 札幌.
  • Year and Date: 2016-05-27
  • Invited
• [Presentation] Increased Plasma Protein Acetylation was Associated with Exercise Intolerance in Patients with Heart Failure Assessed by Global Metabolomic Analysis (2016)
  • Author(s): Masaya Tsuda, Shintaro Kinugawa, Arata Fukushima, Takashi Yokota, Shouji Matsushima, Takaaki Furihata, Shingo Takada, Junichi Matsumoto, Takashi Katayama, Takayuki Nakajima, Koichi Okita, Hiroyuki Tsutsui
  • Organizer: 第80回日本循環器病学会学術集会
  • Place of Presentation: 仙台国際センター, 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] Brain-Derived Neurotrophic Factor Regulates Mitochondrial Function through Ampk-Pgc1Α Signaling in the Skeletal Muscle from Mice with Post-infarct Heart Failure (2016)
  • Author(s): Junichi Matsumoto, Shintaro Kinugawa, Shingo Takada, Takaaki Furihata, Wataru Mizushima, Masaya Tsuda, Takayuki Nakajima, Takashi Katayama, Takashi Yokota, Shouji Matsushima, Koichi Okita, Hiroyuki Tsutsui
  • Organizer: 第80回日本循環器病学会学術集会
  • Place of Presentation: 仙台国際センター, 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] Recombinant Human BDNF Increases Exercise Capacity and Mitochondrial Function in the Skeletal Muscle (2016)
  • Author(s): Shingo Takada, Shintaro Kinugawa, Shouji Matsushima, Takashi Yokota, Wataru Mizushima, Takaaki Furihata, Junichi Matsumoto, Masaya Tsuda, Takayuki Nakajima, Takashi Katayama, Arata Fukushima, Koichi Okita, Hiroyuki Tsutsui
  • Organizer: 第80回日本循環器病学会学術集会
  • Place of Presentation: 仙台国際センター, 宮城県仙台市
  • Year and Date: 2016-03-18
• [Presentation] 代謝疾患における運動耐容能の意義 (2016)
  • Author(s): 沖田孝一
  • Organizer: 第7回内部障害リハビリテーションフォーラム
  • Place of Presentation: 札幌医科大学講堂, 北海道札幌市
  • Year and Date: 2016-02-14
  • Invited
• [Presentation] 病態解明のためのNIRS利用とその問題点：the debate continue. (2016)
  • Author(s): 沖田孝一
  • Organizer: 第23回医用近赤外線分光法研究会
  • Place of Presentation: 持田製薬株式会社本社ルークホール（東京）
  • Invited
• [Presentation] 心不全の運動耐容能制限因子Revisited―骨格筋異常の近未来治療― (2016)
  • Author(s): 沖田孝一
  • Organizer: 栃木県心臓リハビリテーション研究会
  • Place of Presentation: 栃木県宇都宮市
  • Invited
• [Presentation] 心臓リハビリテーション：すべてわかるWhy～Howから最先端 (2015)
  • Author(s): 沖田孝一
  • Organizer: 第29回日本冠疾患学会学術集会
  • Place of Presentation: ロイトン札幌, 北海道札幌市
  • Year and Date: 2015-11-20
  • Invited
• [Presentation] Recombinant human BDNF can mimic effects of exercise training in mice (2015)
  • Author(s): Takada S, Kinugawa S, Matsushima S, Yokota T, Mizushima W, Furihata T, Matsumoto J, Tsuda M, Fukushima A, Okita K, Tsutsui H
  • Organizer: 88th Scientific Session of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Deletion of NAD(P)H oxidase 2 attenuates angiotensin II-induced skeletal muscle atrophy (2015)
  • Author(s): Mizushima W, Kinugawa S, Kadoguchi T, Takada S, Fukushima A, Furihata T, Matsumoto J, Tsuda M, Yokota T, Matsushima S, Okita K, Tsutsui H
  • Organizer: 88th Scientific Session of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Brain-derived neurotrophic factor could regulate mitochondrial function in the skeletal muscle through ampk-pgc1a signaling in heart failure mice (2015)
  • Author(s): Matsumoto J, Kinugawa S, Takada S, Furihata T, Mizushima W, Tsuda M, Nakajima T, Katayama T, Fukuoka R, Yokota T, Matsushima S, Okita K, Tsutsui H
  • Organizer: 88th Scientific Session of American Heart Association
  • Place of Presentation: Orlando, USA
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] 心疾患における運動の意義 (2015)
  • Author(s): 沖田孝一
  • Organizer: 第34回未病システム学会
  • Place of Presentation: 北海道大学学術交流会館, 北海道札幌市
  • Year and Date: 2015-10-11
  • Invited
• [Presentation] 心不全モデルマウスにおける骨格筋ミトコンドリア機能低下に対する脳由来神経栄養因子の役割解明 (2015)
  • Author(s): 高田真吾、絹川真太郎、横田卓、松島将士、沖田孝一、筒井裕之
  • Organizer: 第70回日本体力医学会
  • Place of Presentation: 和歌山県民文化会館、和歌山県和歌山市
  • Year and Date: 2015-09-18
• [Presentation] 喫煙者における運動療法の効果 (2015)
  • Author(s): 田尾賢吾、沖田孝一、田中寿人、熊谷礼、高田真吾
  • Organizer: 第70回日本体力医学会
  • Place of Presentation: 和歌山県民文化会館、和歌山県和歌山市
  • Year and Date: 2015-09-18
• [Presentation] 諸体力指標と動脈硬化危険因子の関連にていて (2015)
  • Author(s): 熊谷礼、沖田孝一、田尾賢吾、田中寿人、高田真吾
  • Organizer: 第70回日本体力医学会
  • Place of Presentation: 和歌山県民文化会館、和歌山県和歌山市
  • Year and Date: 2015-09-18
• [Presentation] 身体機能高度低下高齢者における複合的音楽療法の有用性 (2015)
  • Author(s): 沖田孝一
  • Organizer: 第34回日本臨床運動療法学会
  • Place of Presentation: 東北大学医学部・艮陵会館,
  • Year and Date: 2015-09-05
  • Invited
• [Presentation] NAD(P)H oxidase 2はアンジオテンシンII誘発性の骨格筋萎縮を制御する (2015)
  • Author(s): 門口智泰, 絹川真太郎, 高田真吾, 福島 新, 降旗高明, 工藤雅人, 松本純一, 津田正哉, 横田 卓, 松島将士, 沖田孝一, 筒井 裕之
  • Organizer: 第21回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 福岡国際会議場, 福岡県博多市
  • Year and Date: 2015-07-18
• [Presentation] DPP-4 inhibitor improved exercise capacity in mice with heart failure (2015)
  • Author(s): Takada Shingo, Kinugawa Shintaro, Masaki Yoshihiro, Kadoguchi Tomoyasu, Arata Fukushima, Furihata Takaaki, Mizushima Wataru, Matsumoto Junichi, Tsuda Masaya, Kudo Masato, Matsushima Shouji, Yokota Takashi , Okita Koichi, Tsutsui Hiroyuki
  • Organizer: 第21回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 福岡国際会議場, 福岡県博多市
  • Year and Date: 2015-07-18
• [Presentation] 血液生化学的動脈硬化指標の有用性と問題点：介入による体組成変化を踏まえた検討 (2015)
  • Author(s): 沖田孝一
  • Organizer: 第21回日本心臓リハビリテーション学会学術集会
  • Place of Presentation: 福岡国際会議場, 福岡県博多市
  • Year and Date: 2015-07-18
• [Presentation] Peripheral myopathy in heart failure: pathophysiology and therapeutic implication. Symposium: Issues in hypodynamic disabilities: sarcopenia, myopathy and disautonomy in heart failure (2015)
  • Author(s): Okita K
  • Organizer: EuroPRevent 2015
  • Place of Presentation: Centro de Congressos de Lisboa, Portugal
  • Year and Date: 2015-05-14
  • Int'l Joint Research / Invited
• [Presentation] Potential protocols in resistance exercise with blood flow restriction for muscular adaptationKadoguchi T, Inagawa Y, Yamamoto K, Okita K. Potential protocols in resistance exercise with blood flow restriction for muscular adaptation (2015)
  • Author(s): Tanaka H, Takada S, Kadoguchi T, Inagawa Y, Yamamoto K, Okita K
  • Organizer: World Confederation for Physical Therapy Congress 2015
  • Place of Presentation: Suntec Singapore Convention & Exhibition Centre, Singapore
  • Year and Date: 2015-05-01
  • Int'l Joint Research
• [Book] ―実践EBM 心臓リハビリテーション（エビデンス、診療ギャップとその対応） (2016)
  • Author(s): 沖田孝一、米澤一也（分担）：第II章トレーニング法の適応
  • Total Pages: 17
  • Publisher: 文光堂
• [Book] 心不全患者に寄り添う：包括的心臓リハビリテーションを極める（心不全における運動耐容能規定因子を分担） (2016)
  • Author(s): 絹川真太郎編集（分担：沖田孝一）
  • Publisher: 文光堂
• [Book] 生涯スポーツと運動の科学８メディカルチェック、熱中症予防と対策を分担） (2016)
  • Author(s): 上杉 尹宏、晴山 紫恵子、川初 清典監修（分担：沖田孝一）
  • Publisher: 市村出版