| Project/Area Number |
15K01686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Nakajima Hisakazu 京都府立医科大学, 医学(系)研究科(研究院), 講師 (80363985)
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| Co-Investigator(Kenkyū-buntansha) |
小坂 喜太郎 京都府立医科大学, 医学(系)研究科(研究院), 特任准教授 (60363983)
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Jun 京都府立医科大学, 医学研究科, 助教 (20750011)
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| Research Collaborator |
SUGIMOTO Satoru 京都府立医科大学, 医学研究科, 研修員
KODO Kazuki 京都府立医科大学, 医学研究科, 助教
ITOH Ikuyo 京都府立医科大学, 医学研究科, 研修員
FUKUHARA Syota 京都府立医科大学, 医学研究科, 大学院生
SHIGEHARA Keiichi 京都府立医科大学, 医学研究科, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小児肥滿 / FTO遺伝子 / 遺伝子多型 / 小児肥満 / エピジェネティクス / 視床下部 / ＦＴＯ遺伝子 / エネルギー代謝 |
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| Outline of Final Research Achievements |
We investigated whether the SNPs of FTO gene could contribute to childhood obesity, its comorbidities and its milestone with early-onset among Japanese school-aged population. We identified that the A allele of FTO rs9939609 (T/A) contributed to a high odds ratio for the population with childhood obesity(Odds ratio 4.76; 95% CI1.96-11.1, p=0.008). However, the A allele of FTO rs9939609 did not influence the phenotype and comorbidities including BMI, BMI-Z score, the percentage of overweight, fasted blood glucose, fasted insulin, HOMA-R, serum parameters of lipid metabolism. There was no relationships between FTO rs7206970(C/G) and childhood obesity as well as its complications. FTO rs11644943(T/A) did not influence childhood obesity and its comobidities.
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