The relationships between the genetic polymorphisms of FTO gene and childhood obesity
| Project/Area Number |
15K01686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Nakajima Hisakazu 京都府立医科大学, 医学(系)研究科(研究院), 講師 (80363985)
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| Co-Investigator(Kenkyū-buntansha) |
小坂 喜太郎 京都府立医科大学, 医学(系)研究科(研究院), 特任准教授 (60363983)
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| Co-Investigator(Renkei-kenkyūsha) |
MORI Jun 京都府立医科大学, 医学研究科, 助教 (20750011)
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| Research Collaborator |
SUGIMOTO Satoru 京都府立医科大学, 医学研究科, 研修員
KODO Kazuki 京都府立医科大学, 医学研究科, 助教
ITOH Ikuyo 京都府立医科大学, 医学研究科, 研修員
FUKUHARA Syota 京都府立医科大学, 医学研究科, 大学院生
SHIGEHARA Keiichi 京都府立医科大学, 医学研究科, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小児肥滿 / FTO遺伝子 / 遺伝子多型 / 小児肥満 / エピジェネティクス / 視床下部 / ＦＴＯ遺伝子 / エネルギー代謝 |
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| Outline of Final Research Achievements |
We investigated whether the SNPs of FTO gene could contribute to childhood obesity, its comorbidities and its milestone with early-onset among Japanese school-aged population. We identified that the A allele of FTO rs9939609 (T/A) contributed to a high odds ratio for the population with childhood obesity(Odds ratio 4.76; 95% CI1.96-11.1, p=0.008). However, the A allele of FTO rs9939609 did not influence the phenotype and comorbidities including BMI, BMI-Z score, the percentage of overweight, fasted blood glucose, fasted insulin, HOMA-R, serum parameters of lipid metabolism. There was no relationships between FTO rs7206970(C/G) and childhood obesity as well as its complications. FTO rs11644943(T/A) did not influence childhood obesity and its comobidities.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Genetic heterogeneity of patients with suspected Silver-Russell syndrome: genome-wide copy number analysis in 82 patients without imprinting defects.2017
Author(s)
Inoue T, Nakamura A, Fuke T, Yamazawa K, Sano S, Matsubara K, Mizuno S, Matsukura Y, Harashima C, Hasegawa T, Nakajima H, Tsumura K, Kizaki Z, Oka A, Ogata T, Fukami M, Kagami M.
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Journal Title
Clin Epigenetics
Volume: 9
Issue: 1
Pages: 52-52
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Erythropoietin ameliorates obesity and glucose intolerance on high fat dietary obese mice through the activation of erythropoietin receptor/STAT3 pathway and the up-regulation of FGF21 secretion on classical brown adipose tissue2016
Author(s)
Nakajima H, Kodo K, Sugimoto S, Itoh I, Fukuhara S, Shigehara K, Morimoto H, Nishikawa T, Mori J, Kosaka K, Hosoi H.
Organizer
The 9th biennial Scientific Meeting of the Asia Pacific Paediatric Endocrinology Society/the 50th annual Meeting of the Japanese Society for Pediatric Endocrinology (APPES &JSPE)
Place of Presentation
東京（日本）
Year and Date
2016-11-17
Related Report
Int'l Joint Research
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[Presentation] The collapse of BDNF/POMC system is responsible for the extreme obesity with hyperphagia in female MeCP2 knockout mice fed with high-fat diet2016
Author(s)
Fukuhara S, Nakajima H, Kodo K, Sugimoto S, Itoh I, Shigehara K, Mori J, Morimoto H, Moroto M, Morimoto M, Hosoi H.
Organizer
The 55th meeting of European Society of Paediatric Endocrinology （ESPE)
Place of Presentation
パリ （フランス）
Year and Date
2016-10-10
Related Report
Int'l Joint Research
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