Study on the significance of microRNAs as a biomarker in lifestyle-related diseases

• Project/Area Number: 15K01701
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Tsukuba
• Principal Investigator: Suzuki Hiroaki 筑波大学, 医学医療系, 准教授 (40344890)
• Co-Investigator(Kenkyū-buntansha): 岩崎 仁 筑波大学, 医学医療系, 講師 (20626874) ; 深津 佳世子 (佐々木) 茨城キリスト教大学, 生活科学部, 准教授 (70338903)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: microRNA / バイオマーカー / 生活習慣病 / micorRNA / 玄米 / 糖尿病 / 肥満 / 合併症 / 癌

Outline of Final Research Achievements

We examined the significance of circulating microRNAs (miRNAs) as a biomarker in lifestyle-related diseases. Changes in circulating miRNAs were examined using serum samples of participants enrolled in a randomized controlled trial comparing the effects of brown rice consumption and white rice consumption on body weight and serum glucose and lipids levels. Multiple circulating miRNAs were changed differently between the brown rice group and white rice group. In the brown rice group, the body weight was significantly decreased compared with the white rice group. The changes of circulating miRNAs suggested that brown adipocytes activation is not a cause of the weight loss effect of brown rice consumption. We also identified a miRNA which affects insulin resistance and serum lipid levels.

Research Products

• [Journal Article] Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes (2018)
  • Author(s): Shoko Furukawa, Hiroaki Suzuki, Kazuya Fujihara, Kazuto Kobayashi, Hitoshi Iwasaki, Yoko Sugano, Shigeru Yatoh, Motohiro Sekiya, Naoya Yahagi, Hitoshi Shimano
  • Journal Title: Diabetes Research and Clinical Practice Volume: 印刷中
  • NAID: 120007133948
  • Peer Reviewed
• [Journal Article] Effect of partially-abraded brown rice consumption on body weight and the indicators of glucose and lipid metabolism in pre-diabetic adults: A randomized controlled trial (2017)
  • Author(s): Risa Araki, Reiko Ushio, Keiko Fujie, Yukari Ueyama, Hiroaki Suzuki, Yoshio Nakata, Koichi Hashimoto
  • Journal Title: Clinical Nutrition ESPN Volume: 印刷中 Pages: 9-15
  • DOI: 10.1016/j.clnesp.2017.01.015
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 表面加工玄米の継続摂取による脂質代謝改善効果の検討：リポタンパク質粒子サイズ解析に基づく血中脂質プロファイル (2017)
  • Author(s): 荒木理沙、潮玲子、藤江敬子、植山ゆかり、鈴木浩明、中田由夫、橋本幸一
  • Organizer: 日本農芸化学会2017年度大会
• [Presentation] 表面加工玄米の継続摂取による体重減少効果 (2017)
  • Author(s): 植山ゆかり、荒木理沙、藤江敬子、忌部尚、宮脇正博、鈴木浩明、中田由夫、谷本啓爾、佐野寛行、寺前純吾、花房俊昭、橋本幸一
  • Organizer: つくば医工連携フォーラム2017
• [Presentation] 表面加工玄米の継続摂取による肥満改善効果 ランダム化比較試験 (2016)
  • Author(s): 荒木理沙、潮玲子、藤江敬子、植山ゆかり、鈴木浩明、中田由夫、橋本幸一
  • Organizer: 第37回日本肥満学会
  • Place of Presentation: 東京ファッションタウン・東京都・江東区
  • Year and Date: 2016-10-07
• [Presentation] Serum malondialdehyde-modified LDL levels are increased in type 2 diabetic patients with nephropathy (2016)
  • Author(s): Hiroaki Suzuki, Shoko Furukawa, Kazuya Fujihara, Kazuto Kobayashi, Hitoshi Iwasaki, Shigeru Yato, Motohiro Sekiya, Naoya Yahagi, Hiroaki Yagyu, Hitoshi Shimano
  • Organizer: European Association for the Study of Diabetes 2016 Annual Meeting
  • Place of Presentation: ミュンヘン（ドイツ）
  • Year and Date: 2016-09-12
  • Int'l Joint Research
• [Presentation] 2型糖尿病におけるMDA-LDLと腎症との関連 (2016)
  • Author(s): 鈴木浩明、古川祥子、藤原和哉、岩﨑仁、小林和人、矢藤繁、関谷元博、矢作直也、伊坂正明、野牛宏晃、島野仁
  • Organizer: 第48回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル・東京都・新宿区
  • Year and Date: 2016-07-14
• [Presentation] MDA-LDLと糖尿病細小血管障害との関連 (2016)
  • Author(s): 古川祥子、鈴木浩明、藤原和哉、岩﨑仁、小林和人、矢藤繁、矢作直也、野牛宏晃、島野仁
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 国立京都国際会館・京都府・京都市
  • Year and Date: 2016-05-19
• [Presentation] 糖尿病性腎症と心血管疾患に関する検討 (2016)
  • Author(s): 鈴木浩明、古川祥子、岩﨑仁、小林和人、矢藤繁、矢作直也、野牛宏晃、島野仁
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 国立京都国際会館・京都府・京都市
  • Year and Date: 2016-05-19