• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the transformation mechanisms of a cognitive function and activity in brain reward prcessing after bariatric surgery in obesity

Research Project

Project/Area Number 15K01703
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionChiba University

Principal Investigator

Matsumoto Junko  千葉大学, 大学院医学研究院, 特任助教 (60722262)

Co-Investigator(Kenkyū-buntansha) 平野 好幸  千葉大学, 子どものこころの発達教育研究センター, 教授 (50386843)
徳山 宏丈  千葉大学, 大学院医学研究院, 特任助教 (90385039)
Research Collaborator YOKOTE Koutaro  
ONO Hiraku  
KITAHARA Aya  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords高度肥満症 / 肥満外科手術 / 認知機能 / 脳機能 / 脳形態 / 肥満症外科手術 / 肥満症外科治療 / 高度肥満 / 肥満外科治療
Outline of Final Research Achievements

The aim of this study was to investigate whether the cognitive function such as set-shifting, decision-making abilities and reward processing during the monetary incentive delayed (MID) task using functional magnetic resonance imaging (fMRI) and volumetric analysis, were altered in patients with obesity who undergoing bariatric surgery (BS) and non-surgical patients (NS) before, after six months, and at 18-month follow up. Compared with NS group, BMI in BS individuals who underwent bariatric surgery was significantly lower than in the NS at the six months after, and at 18-month follow-up from baseline. No significant differences among intelligence quotient, cognitive function such as set-shifting and decision-making abilities in BS and NS were observed.
Response time during MID task was not changed at six months after surgery at interim analysis. However, bilateral thalamus and left putamen and amygdala activation tended to be increased in the prospect reward phase

Academic Significance and Societal Importance of the Research Achievements

肥満外科手術によって、肥満症患者の自尊感情やQOL、認知機能の改善が見込まれることが報告されている。他方、肥満症患者の味覚と嗅覚連合野の活動が外科手術後に減少していることから、食への欲求の減少が、食品写真課題を用いたfMRIによる研究で報告されている。しかしながら、わが国において、報酬系自体の活動変化と認知的制御を伴っているかどうかは未だ確認されていない。その点で、本研究の意義は大きい。
今回の結果は、肥満症患者の外科手術後の認知機能の改善は見られず、さらに、食への欲求に関連する脳の報酬系活動は依然として増加傾向にあることが示唆されたことから、今後、術後の包括的アプローチを再考する必要がある。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (36 results)

All 2018 2017 2016 2015 Other

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 14 results,  Open Access: 5 results) Presentation (20 results) (of which Int'l Joint Research: 10 results,  Invited: 1 results) Remarks (2 results)

  • [Journal Article] 成人肥満と精神神経薬剤処方数は関連する ―レセプト情報・特定健診等情報データベース(第1回NDBオープンデータ)から2018

    • Author(s)
      松本淳子、平野好幸、須藤千尋、清水栄司、横手幸太郎
    • Journal Title

      調査研究ジャーナル

      Volume: 7 Pages: 14-20

    • NAID

      40021618140

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A single-arm pilot study of guided self-help treatment based cognitive behavioral therapy for bulimia nervosa in Japanese clinical settings2018

    • Author(s)
      Setsu R, Asano K, Numata N, Tanaka M, Ibuki H, Yamamoto T, Uragami R, Matsumoto J, Hirano Y, Iyo M, Shimizu E, Nakazato M.
    • Journal Title

      BMC Res Notes.

      Volume: Apr 25;11(1) Issue: 1 Pages: 257-257

    • DOI

      10.1186/s13104-018-3373-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Does cognitive behavioral therapy alter mental defeat and cognitive flexibility in patients with panic disorder?2018

    • Author(s)
      Nagata S , Seki Y, Shibuya T, Yokoo M, Murata T, Hiramatsu Y, Yamada F, Ibuki H, Minamitani N, Yoshinaga N, Kusunoki M, Inada Y, Kawasoe N, Adachi S, Oshiro K, Matsuzawa D, Hirano Y, Yoshimura K, Nakazato M, Iyo M, Nakagawa A, Shimizu E.
    • Journal Title

      BMC Res Notes.

      Volume: 11 Issue: 1 Pages: 23-23

    • DOI

      10.1186/s13104-018-3130-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of the BOLD and CBV fMRI responses to somatosensory stimulation in awake marmosets (Callithrix jacchus).2018

    • Author(s)
      Hirano Y, Yen CC, Liu JV, Mackel JB, Merkle H, Nascimento GC, Stefanovic B, Silva AC.
    • Journal Title

      NMR Biomed, in press

      Volume: - Issue: 3

    • DOI

      10.1002/nbm.3864

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparison of brain activity between motor imagery and mental rotation of the hand tasks: a functional magnetic resonance imaging study.2018

    • Author(s)
      Hamada H, Matsuzawa D, Sutoh C, Hirano Y, Chakraborty S, Ito H, Tsuji H, Obata T, Shimizu E.
    • Journal Title

      Brain Imaging Behav, in press

      Volume: - Issue: 6 Pages: 1596-1606

    • DOI

      10.1007/s11682-017-9821-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reliability and validity of the Japanese version of the Obsessive-Compulsive Inventory-Revised (OCI-R).2018

    • Author(s)
      Koike H, Tsuchiyagaito A, Hirano Y, Oshima F, Asano K, Sugiura Y, Kobori O, Ishikawa R, Nishinaka H, Shimizu E, Nakagawa A.
    • Journal Title

      Curr Psychol, in press

      Volume: -

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hemodynamic responses in prefrontal cortex and personality characteristics in patients with bulimic disorders: a near-infrared spectroscopy study.2018

    • Author(s)
      Numata N, Hirano Y, Sutoh C, Matsuzawa D, Takeda K, Setsu R, Shimizu E, Nakazato M.
    • Journal Title

      Eat Weight Disord, in press

      Volume: - Issue: 1 Pages: 1-9

    • DOI

      10.1007/s40519-018-0500-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gender-specific associations of depression and anxiety symptoms with mental rotation.2018

    • Author(s)
      Oshiyama C, Sutoh C, Miwa H, Okabayashi S, Hamada H, Matsuzawa D, Hirano Y, Takahashi T, Niwa S, Honda M, Sakatsume K, Nishimura T, Shimizu E
    • Journal Title

      J Affect Disord, in press

      Volume: - Pages: 277-284

    • DOI

      10.1016/j.jad.2018.04.006

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Feasibility of cognitive remediation therapy for adults with autism spectrum disorders: a single-group pilot study.2017

    • Author(s)
      Okuda T, Asano K, Numata N, Hirano Y, Yamamoto T, Tanaka M, Matsuzawa D, Shimizu E, Iyo M, Nakazato M.
    • Journal Title

      Neuropsychiatr Dis Treat.

      Volume: 13 Pages: 2185-91

    • DOI

      10.2147/ndt.s141555

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cognitive-behavioral therapy for obsessive-compulsive disorder with and without autism spectrum disorder: gray matter differences associated with poor outcome.2017

    • Author(s)
      Tsuchiyagaito A, Hirano Y, Asano K, Oshima F, Nagaoka S, Takebayashi Y, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
    • Journal Title

      Front Psychiatry

      Volume: 8 Pages: 143-143

    • DOI

      10.3389/fpsyt.2017.00143

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased subjective distaste and altered insula activity to umami tastants in patients with bulimia nervosa.2017

    • Author(s)
      Setsu R, Hirano Y, Tokunaga M, Takahashi T, Numata N, Matsumoto K, Masuda Y, Matsuzawa D, Iyo M, Shimizu E, Nakazato M.
    • Journal Title

      Front Psychiatry.

      Volume: 8 Pages: 172-172

    • DOI

      10.3389/fpsyt.2017.00172

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Relationship between symptom dimensions and brain morphology in obsessive-compulsive disorder2017

    • Author(s)
      Hirose M, Hirano Y, Nemoto K, Sutoh C, Asano K, Miyata H, Matsumoto J, Nakazato M, Matsumoto K, Masuda Y, Iyo M, Shimizu E, Nakagawa A.
    • Journal Title

      Brain Imaging and Behavior

      Volume: 印刷中 Issue: 5 Pages: 1326-33

    • DOI

      10.1007/s11682-016-9611-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders2017

    • Author(s)
      Matsumoto J, Hirano Y, Hashimoto K, Ishima T, Kanahara N, Niitsu T, Shiina A, Hashimoto T, MD, Sato Y, Yokote K, Murano S, KimuraH, Hosoda Y, Shimizu E, Iyo M, and Nakazato M
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 71 Issue: 2 Pages: 124-134

    • DOI

      10.1111/pcn.12490

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns2015

    • Author(s)
      Matsumoto J, Hirano Y, Numata N, Matsuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.
    • Journal Title

      J Eat Disord

      Volume: 3 Issue: 1 Pages: 14-14

    • DOI

      10.1186/s40337-015-0050-6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A longitudinal follow-up study of cognitive function in obesity after bariatric surgery2018

    • Author(s)
      Matsumoto J, Hirano Y, Kitahara A, Ono H, Tokuyama H, Yokote K
    • Organizer
      The 23rd IFSO World Congress,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Longitudinal reward processing alteration at 18-month follow-up after bariatric surgery in obesity2018

    • Author(s)
      Hirano Y, Matsumoto J, Kitahara A , Ono H , Matsumoto K , Masuda Y, Shimizu E , Yokote K
    • Organizer
      The 23rd IFSO World Congress,
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 成人肥満と精神神経薬剤処方数は関連する-平成25年度レセプト情報・特定健診等情報データベース(NDB)オープンデータから-2017

    • Author(s)
      松本淳子、平野好幸、須藤千尋、清水栄司、横手幸太郎
    • Organizer
      第35回日本肥満症治療学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 肥満外科手術における報酬処理の変化2017

    • Author(s)
      平野好幸、松本淳子、北原綾、徳山宏丈、山賀政弥、北本匠、松本浩史、桝田喜正、清水栄司、横手幸太郎
    • Organizer
      第35回日本肥満症治療学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Cognitive function in bariatric surgery versus non-surgical patients for obesity2017

    • Author(s)
      Matsumoto J, Hirano Y, Kitahara A, Tokuyama H, Yamaga M, Kitamoto T, Yokote K
    • Organizer
      The 24th European Congress on Obesity, Porto, Portugal
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reward processing alteration after bariatric surgery in obesity2017

    • Author(s)
      Hirano Y, Matsumoto J, Kitahara A, Tokuyama H, Yamaga M, Kitamoto T, Matsumoto K, Masuda Y, Shimizu E, Yokote K
    • Organizer
      The 24th European Congress on Obesity, Porto, Portugal
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neurostructural predictors of cognitive behavioral therapy (CBT) for obsessive-compulsive disorder: implications for the integration of neurofeedback training and CBT.2017

    • Author(s)
      Tsuchiyagaito A, Hirano Y, Tazaki M, Nakagawa A.
    • Organizer
      25th Annual ISNR Conference,Mashantucket
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] OCD with and without ASD: Do differential brain alternative predict CBT outcomes?2017

    • Author(s)
      Tsuchiyagaito A, Hirano Y, Shimizu E, Nakagawa A.
    • Organizer
      24th Annual OCD Conference San Francisco
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 認知行動療法と脳画像, 教育講演2017

    • Author(s)
      平野好幸
    • Organizer
      第34回日本行動科学会ウィンターカンファレンス
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 神経性過食症に対する個人認知行動療法の効果研究2017

    • Author(s)
      薛陸景、浅野憲一、伊吹英恵、沼田法子、田中麻里、平野好幸、清水栄司、中里道子
    • Organizer
      第21回日本摂食障害学会学術集会.広島
    • Related Report
      2017 Research-status Report
  • [Presentation] より良い治療効果を得るために―自閉スペクトラム症を併存する強迫症に対する認知行動療法の効果と関連する脳部位を用いたモデル検討―2017

    • Author(s)
      土屋垣内晶、平野好幸、竹林由武、清水栄司、中川彰子
    • Organizer
      第44回日本脳科学学会.弘前
    • Related Report
      2017 Research-status Report
  • [Presentation] Evaluation of relationship between BOLD signal and cerebral blood flow in activated state by simultaneous ASL and BOLD measurement2017

    • Author(s)
      Ikoma Y, Obata T, Hirano Y, Tachibana A, Tachibana Y, Murata K, Higashi T.
    • Organizer
      第45回日本磁気共鳴医学会大会.宇都宮
    • Related Report
      2017 Research-status Report
  • [Presentation] Time-lag assessment of neuronal connectivity for default mode network by multi-band rsfMRI.2017

    • Author(s)
      Tachibana A, Ikoma Y, Hirano Y, Tachibana Y, Higashi T, Obata T.
    • Organizer
      第45回日本磁気共鳴医学会大会.宇都宮
    • Related Report
      2017 Research-status Report
  • [Presentation] Eating and weight/shape concerns in obese women; comparison with bulimia nervosa and healthy women2016

    • Author(s)
      Matsumoto J, Kitahara A, Tokuyama H, Murano S, Nakazato M, Yokote K
    • Organizer
      The 22nd Eating Disorders Research Society Annual Meeting
    • Place of Presentation
      New York, USA
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Improvement Effect by Cognitive Behavioral Therapy for Highly Obese Patient: A Case Study2016

    • Author(s)
      Matsumoto J, Murano S
    • Organizer
      The 17th Asian Congress on Psychosomatic Medicine
    • Place of Presentation
      The Kyushu University School of Medicine Centennial Hall ,Fukuoka, Japan
    • Year and Date
      2016-08-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Altered serum level of matrix metalloproteinase-9 and its association with decision-making in eating disorders2016

    • Author(s)
      Matsumoto J, Hirano Y, Hashimoto K, Ishima T, Sato Y, Yokote K, Murano S, Kimura H, Hosoda Y, Shimizu E, Iyo M and Nakazato M
    • Organizer
      124th American Psychological Association Annual Convention
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      2016-08-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肥満症女性患者における食行動、体重、体形への“とらわれ”の特徴2016

    • Author(s)
      松本淳子, 北原綾, 徳山宏丈, 高梨敬子, 山賀政弥, 正司真弓, 村野俊一, 中里道子, 横手幸太郎
    • Organizer
      第34回日本肥満症治療学会学術集会
    • Place of Presentation
      東京コンベンションホール(東京都中央区)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Research-status Report
  • [Presentation] むちゃ食い障害を伴った肥満症患者に対して認知行動療法を行った1例2016

    • Author(s)
      北原綾, 松本淳子, 徳山宏丈, 山賀政弥, 正司真弓, 野本尚子, 竹本稔, 中里道子, 横手幸太郎
    • Organizer
      第34回日本肥満症治療学会学術集会
    • Place of Presentation
      東京コンベンションホール(東京都中央区)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Research-status Report
  • [Presentation] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns2015

    • Author(s)
      Matsumoto J, Hirano Y, Numata N, Matzuzawa D, Murano S, Yokote K, Iyo M, Shimizu E and Nakazato M
    • Organizer
      21st Eating Disorders Research Society Annual Meeting
    • Place of Presentation
      Taormina, Sicily(Italy)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 認知行動的アプローチによる改善の効果: 高度肥満症患者の一例2015

    • Author(s)
      松本淳子 村野俊一 鯉沼佳子 徳山宏丈 北原綾 服部暁子 野本尚子 中里道子 平野好幸  横手幸太郎
    • Organizer
      第33回日本肥満症治療学会学術集会
    • Place of Presentation
      幕張国際研修センター(千葉県千葉市)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Remarks] 研究内容 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター:

    • URL

      https://www.m.chiba-u.ac.jp/class/rccmd/researcher/research.html

    • Related Report
      2018 Annual Research Report
  • [Remarks] 千葉大学大学院医学研究院細胞治療内科学

    • URL

      http://www.m.chiba-u.jp/class/clin-cellbiol/research/contents/disaster.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi