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Analysis of bone metabolism under hyperglycemia using unique type 2 diabetes model and proposal of improvement method for bone metabolism in type 2 diabetes by exercise.

Research Project

Project/Area Number 15K01705
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionKanazawa University

Principal Investigator

KITAMURA Kei-ichiro  金沢大学, 保健学系, 教授 (80283117)

Co-Investigator(Kenkyū-buntansha) 鈴木 信雄  金沢大学, 環日本海域環境研究センター, 教授 (60242476)
池亀 美華  岡山大学, 医歯薬学総合研究科, 准教授 (70282986)
Co-Investigator(Renkei-kenkyūsha) HONDA Masao  金沢大学, 保健学系, 教授 (00272980)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords糖尿病 / キンギョ / 高でんぷん含有飼料 / 骨代謝 / 再生ウロコ / コラーゲン線維 / 糖化 / 運動 / エキソーム解析
Outline of Final Research Achievements

We used fish, characterized by a prolonged hour hyperglycemia after starch-rich feeding, as a unique model of type 2 DM. In this model, the interfibrous crosslinking caused by production of advanced glycation end products accompanying the glycation of type I collagen fiber was increased. Furthermore, analysis of three-points bending test of glycated type I collagen fiber demonstrated that the increment of interfibrous crosslinking of collagen fibers leads to decrease of collagen fiber elasticity and of bending strength of collagen fiber. Our results indicated that the glycation of bone structure proteins bring increment of fracture risk.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (27 results)

All 2018 2017 2016 2015 Other

All Journal Article (16 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 16 results,  Open Access: 12 results,  Acknowledgement Compliant: 8 results) Presentation (9 results) (of which Int'l Joint Research: 2 results) Remarks (2 results)

  • [Journal Article] a-melanocyte-stimulating hormone promotes the bone resorption resulting from increased osteoblastic and osteoclastic activities in goldfish.2018

    • Author(s)
      Ishizu, H., Sekiguchi, T., Ikari, T.,, Kitamura, K., Kitani, Y., Endo, M., Urata, M., Kinoshita, Y., Hattori, A., Srivastav, A.K., Mishima, H., Mizusawa, K., Takahashi, A. and Suzuki, N.
    • Journal Title

      Gen. Comp. Endocrinol.

      Volume: 262 Pages: 99-105

    • DOI

      10.1016/j.ygcen.2018.03.020

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of hyperglycemia on bone metabolism and bone matrix in goldfish scales.2017

    • Author(s)
      Kitamura K, Andoh T, Okesaku W, Tazaki Y, Ogai K, Sugitani K, Kobayashi I, Suzuki N, Chen W, Ikegame M, Hattori A
    • Journal Title

      Comparative Biochemistry and Physiology, Part A

      Volume: 203 Pages: 152-158

    • DOI

      10.1016/j.cbpa.2016.09.010

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] <b>Effects of low-intensity pulsed ultrasound on osteoclasts: Analysis with goldfish scales as a model of </b><b>bone </b>2017

    • Author(s)
      Hanmoto T, Tabuchi Y, Ikegame M, Kondo T, Kitamura KI, Endo M, Kobayashi I, Mishima H, Sekiguchi T, Urata M, Seki A, Yano S, Hattori A, Suzuki N.
    • Journal Title

      Biomedical Research

      Volume: 38 Issue: 1 Pages: 71-77

    • DOI

      10.2220/biomedres.38.71

    • NAID

      130005242919

    • ISSN
      0388-6107, 1880-313X
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sardine procalcitonin amino-terminal cleavage peptide has a different action from calcitonin and promotes osteoblastic activity in the scales of goldfish.2017

    • Author(s)
      Kase, Y., Ikari, T., Sekiguchi, T., Sato, M., Ogiso, S., Kawada, T., Matsubara, S., Satake, H., Sasayama, Y., Endo, M., Kitamura, K., Hattori, A., Watanabe, T.X., Maruyama, Y., Watanabe, Y., Funahashi, H., Kambegawa, A. and Suzuki, N.
    • Journal Title

      Comp. Biochem. Physiol. Part A

      Volume: 211 Pages: 73-83

    • DOI

      10.1016/j.cbpa.2017.06.007

    • NAID

      120006336026

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Is vaccenic acid (18:1t n-7) associated with an increased incidence of hip fracture? An explanation for the calcium paradox.2016

    • Author(s)
      Hamazaki, K., Suzuki, N., Kitamura, K., Hattori, A., Nagasawa, T., Itomura, M., and Hamazaki, T.
    • Journal Title

      Prostaglandins Leukot. Essent. Fatty Acids

      Volume: 109 Pages: 8-12

    • DOI

      10.1016/j.plefa.2016.04.001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fish scale is a suitable model for analyzing determinants of skeletal fragility in type 2 diabetes.2016

    • Author(s)
      Suzuki N, Kitamura K, Hattori A
    • Journal Title

      Endocrine

      Volume: 54 Issue: 3 Pages: 575-577

    • DOI

      10.1007/s12020-016-1153-9

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A detailed protocol for perspiration monitoring using a novel, small, wireless device.2016

    • Author(s)
      Ogai K, Fukuoka M, Kitamura K, Uchide K, Nemoto T
    • Journal Title

      J Vis Exp

      Volume: 24 Issue: 117

    • DOI

      10.3791/54837

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term Measurement of Maternal Pulse Rate Dynamics Using a Home-based Sleep Monitoring System.2016

    • Author(s)
      Chen Y., Chen W, Kitamura K., Nemoto T
    • Journal Title

      Journal of Sensors

      Volume: in press Pages: 1-11

    • DOI

      10.1155/2016/5730142

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a small wireless device for perspiration monitoring.2016

    • Author(s)
      Ogai K, Fukuoka M, Kitamura K, Uchide K, Nemoto T
    • Journal Title

      Med Eng Phys.

      Volume: 38 Issue: 4 Pages: 391-397

    • DOI

      10.1016/j.medengphy.2015.12.009

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low-intensity pulsed ultrasound induces apoptosis in osteoclasts: Fish scales are a suitable model for the analysis of bone metabolism by ultrasound.2016

    • Author(s)
      Suzuki N, Hanmoto T, Yano S, Furusawa Y, Ikegame M, Tabuchi Y, Kondo T, Kitamura K, Endo M, Yamamoto T, Sekiguchi T, Urata M, Mikuni-Takagaki Y, Hattori A.
    • Journal Title

      Comp. Biochem. Physiol. Part A

      Volume: 195 Pages: 26-31

    • DOI

      10.1016/j.cbpa.2016.01.022

    • NAID

      120005743920

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Increased level of tumor necrosis factor-alpha (TNF-α) on the skin of Japanese obese males: measured by quantitative skin blotting.2016

    • Author(s)
      Ogai K, Matsumoto M, Aoki M, Minematsu T, Kitamura K, Kobayashi M, Sanada H and Sugama J
    • Journal Title

      Int J Cosmet Sci.

      Volume: in press Issue: 5 Pages: 462-469

    • DOI

      10.1111/ics.12312

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Is vaccenic acid (18:1t n-7) associated with an increased incidence of hip fracture? An explanation for the calcium paradox.2016

    • Author(s)
      Hamazaki K., Suzuki N., Kitamura K., Hattori A., Nagasawa T., Itomura M., Hamazaki T.
    • Journal Title

      Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

      Volume: in press

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Monohydroxylated polycyclic aromatic hydrocarbon influences spicule formation in the early development of sea urchins (Hemicentrotus pulcherrimus).2015

    • Author(s)
      Suzuki, N., Ogiso, S., Yachiguchi, K., Kawabe, K., Makino, F., Toriba, A., Kiyomoto, M., Sekiguchi, T., Tabuchi, Y., Kondo, T., Kitamura, K., Hong, C., Srivastav, A.K., Oshima, Y., Hattori, A., Hayakawa, K.
    • Journal Title

      Comp Biochem Physiol C Toxicol Pharmacol.

      Volume: 171 Pages: 55-60

    • DOI

      10.1016/j.cbpa.2015.02.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A basic study for prediction of food hardness based on an acceleration monitoring of lower jaw during mastication.2015

    • Author(s)
      Ogai K, Kitamura K, Nemoto T.
    • Journal Title

      Journal of Nursing Science and Engineering

      Volume: 2 Pages: 9-14

    • NAID

      130006406473

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of an improved method for quantitative analysis of skin blotting: Increasing reliability and applicability for skin assessment.2015

    • Author(s)
      Ogai K, Matsumoto M, Minematsu H, Kitamura K, Kobayashi M, Sugama J and Sanada H
    • Journal Title

      International Journal of Cosmetic Science

      Volume: - Issue: 4 Pages: 425-432

    • DOI

      10.1111/ics.12217

    • NAID

      120005704522

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Novel tryptophan derivatives as potentially effective therapeutic drugs to treat bone diseases.2015

    • Author(s)
      Suzuki, N., Somei, M., Seki, A., Sekiguchi, T., Tabuchi, Y., Mishima, H., Kase, Y., Kaminishi, A., Yachiguchi, K., Kitamura, K., Oshima, Y., Hayakawa, K., Yano, S. and Hattori, A
    • Journal Title

      Am. J. Life Sci.

      Volume: 3 Issue: 3 Pages: 31-38

    • DOI

      10.11648/j.ajls.s.2015030302.16

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] LIPUSに対する骨芽細胞及び破骨細胞の応答:キンギョのウロコを用いたin vitro及びin vivoの解析2018

    • Author(s)
      鈴木信雄、半本泰三、田渕圭章、近藤隆、池亀美華、北村敬一郎、関口俊男、小林功、関あずさ、服部淳彦
    • Organizer
      第21回超音波骨折治療研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 魚類の骨代謝に対する黒色素胞刺激ホルモンの影響:in vivo及びin vitroによる解析2018

    • Author(s)
      鈴木信雄, 石津偉統, 木谷洋一郎, 五十里雄大, 関口俊男, 北村敬一郎, 遠藤雅人, 服部淳彦, 水澤寛太
    • Organizer
      平成30年度公益社団法人日本水産学会春季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] キンギョ高血糖モデルにおける骨代謝および糖化ウロココラーゲンの架橋解析2017

    • Author(s)
      北村敬一郎, 鈴木信雄
    • Organizer
      平成29年度日本動物学会 中部支部大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of α-melanocyte-stimulating hormone on osteoblasts and osteoclasts in the regenerating scales of goldfish.2017

    • Author(s)
      Ishizu H, Sekiguchi T, Ikari T, Kitamura K, Kitani Y, Endo M, Urata M, Hattori A, Mizusawa K, Takahashi A and Suzuki N
    • Organizer
      The 3rd International Symposium to Promote Joint Usage/Research Center 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アロキサン誘発高血糖キンギョモデルにおける骨代謝および糖化ウロココラーゲンの架橋解析.2016

    • Author(s)
      北村敬一郎, 安藤 忠, 大貝 和裕, 杉谷 加代, 鈴木信雄.
    • Organizer
      第55回日本生体医工学会大会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 超小型発汗計による精神性発汗の測定と評価.2016

    • Author(s)
      大貝和裕, 福岡正和, 北村敬一郎, 内出喜義, 根本鉄.
    • Organizer
      第55回日本生体医工学会大会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2016-04-26
    • Related Report
      2016 Research-status Report
  • [Presentation] アロキサン誘発高血糖キンギョにおける骨代謝および骨質の解析.2015

    • Author(s)
      北村敬一郎, 安藤 忠, 桶作若菜, 服部淳彦, 鈴木信雄
    • Organizer
      日本宇宙生物科学会第29回大会
    • Place of Presentation
      帝京大学 板橋キャンパス(東京都板橋区)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 魚類のウロコにおける骨細胞マーカー、sost1の発現と発現細胞の同定.2015

    • Author(s)
      田崎 裕也, 小倉絵梨奈, 坂井 晴香, 杉谷 加代, 北村敬一郎
    • Organizer
      第40回北陸臨床病理集談会
    • Place of Presentation
      金沢大学保健学類(石川県金沢市)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
  • [Presentation] Melatonin effects on stimulated osteoclast activity in the regenerating scales of goldfish under modelled microgravity.2015

    • Author(s)
      Ikegame M, Hattori A, Yamamoto T, Kitamura K, Tabuchi Y, Nakano M, Yano S, Yamamoto T, Suzuki N,
    • Organizer
      13th Congress of the International Society of Bone Morphometry 2015
    • Place of Presentation
      Tokyo,Japan
    • Year and Date
      2015-04-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 研究者情報

    • URL

      http://ridb.kanazawa-u.ac.jp/public/detail.php?id=2619

    • Related Report
      2017 Annual Research Report
  • [Remarks] 金沢大学 研究者情報

    • URL

      http://ridb.kanazawa-u.ac.jp/public/detail.php?id=2619

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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