| Project/Area Number |
15K01715
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
USUI SHINICHI 岡山大学, 保健学研究科, 准教授 (50346417)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
廣畑 聡 岡山大学, 保健学研究科, 教授 (90332791)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
SHINOHATA Ryoko 岡山大学, 大学院保健学研究科, 助教 (70335587)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | HDL / アポリポ蛋白E / 肥満 / 生活習慣病モデルマウス / リポ蛋白 / 細胞培養 / 脂肪細胞 / アポリポ蛋白Ｅ / ＨＤＬ |
|---|
| Outline of Final Research Achievements |
In this study, we established a quantitative method for serum apoE-rich HDL and showed that apoE-rich HDL increased in obese model mice. In clinical study, multiple regression analysis revealed that triglycerides and adiponectin strongly involved in obesity are significant predictors of apoE-rich HDL-cholesterol levels. However, in the culture experiment of adipocytes, we did not obtain data on which apoE-rich HDL was involved in fat accumulation. In cultured hepatocytes, the production of apoE-rich HDL was increased by the high glucose medium, suggesting that glucose uptake by hepatocytes was significantly involved in the production of apoE-rich HDL. A new research progress is expected in the future in relation to glucose metabolism and the production of E-rich HDL in hepatocytes.
|
