Distribution of essential trace elements in deciduous and permanent teeth, its relationship with general health condition of children

• Project/Area Number: 15K01746
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Childhood science (childhood environment science)
• Research Institution: Tohoku University
• Principal Investigator: IGARI Kazuko 東北大学, 大学病院, 講師 (90125493)
• Co-Investigator(Kenkyū-buntansha): 高橋 温 東北大学, 大学病院, 助教 (50333828) ; 松山 成男 東北大学, 工学研究科, 教授 (70219525)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 必須微量元素分析 / 乳歯 / 永久歯 / PIXE法 / 子どもの健康 / 必須微量元素 / 乳歯エナメル質 / 亜鉛 / 健康背景 / 子どもの栄養 / 発達障害

Outline of Final Research Achievements

Zinc (Zn) and copper (Cu) are essential trace elements and important for the development of the brain function. This study aimed to investigate the distribution of these trace elements in the teeth and evaluate its relationship with general conditions of the perinatal period. The low Zn/Cn ratio and relatively low concentrations of Zn were showed in the pre- and postnatal enamel of the deciduous teeth from children with neonatal asphyxia and/or low birth weight. Also, the low concentration of Zn in the dentin was observed in the deciduous tooth from the extremely-low-birth-weight infant. The distributions of Cu were almost same in both enamel and dentin of all teeth. It was suggested that there was a relationship between low birth weight and the deficiency of Zn intake.

Research Products

• [Presentation] Distribution of trace elements in pre- and post-natal enamel of teeth in children with disabilities (2018)
  • Author(s): Yukihiro Naganuma, AtsushiTakahashi, Shigeo Matsuyama, Misako Miwa, Sho Toyama, Keiichi Sasaki, Kazuko Igari
  • Organizer: 24th International Association for Disability and Oral Health
  • Int'l Joint Research
• [Presentation] マイクロPIXEによる永久歯エナメル質の微量元素分析 (2017)
  • Author(s): 長沼由泰・猪狩和子・高橋 温・松山成男・菊池洋平・三輪美沙子・植木 裕・及川紘奈・北山佳治
  • Organizer: 第33回PIXEシンポジウム
• [Presentation] 乳歯エナメル質の微量元素分析－新産線前後での比較－ (2016)
  • Author(s): 猪狩和子・高橋 温・長沼由泰・松山成男・佐多大地・畠山泰輔・鈴木脩平・今泉光太
  • Organizer: 第32回PIXEシンポジウム
  • Place of Presentation: サン・リフレ函館（函館市）
  • Year and Date: 2016-11-09
• [Presentation] 乳歯エナメル質における新産線前後の亜鉛濃度の分析 (2015)
  • Author(s): 猪狩和子・高橋 温・長沼由泰・松山成男・石井慶造・佐多大地・関 大輝・鈴木脩平・畠山泰輔・今泉光太
  • Organizer: 第31回PIXEシンポジウム
  • Place of Presentation: 高崎量子応用研究所（高崎市）
  • Year and Date: 2015-10-28