• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Chemical biological studies

Research Project

Project/Area Number 15K01810
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomolecular chemistry
Research InstitutionChubu University

Principal Investigator

OHNISHI Motoko  中部大学, 応用生物学部, 教授 (00312653)

Co-Investigator(Kenkyū-buntansha) 禹 済泰  中部大学, 応用生物学部, 教授 (20272693)
饒村 修  中部大学, 工学部, 准教授 (20365175)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsプロテインホスファターゼ / 天然低分子物質 / 生理活性物質 / 阻害剤 / 破骨細胞 / シグナル伝達
Outline of Final Research Achievements

Metal-dependent protein phosphatases (PPMs) are Mg2+/Mn2+-dependent enzymes that specifically phosphorylate Ser and Thr residues, and at least 17 different PPM genes are present in the mammalian genome. Although they are central players in disease pathogenesis, only few inhibitors of PPM phosphatases have been reported and more potent and selective small molecules regulating these enzymes are expected to be developed. In this study, the docking simulation was performed for several small molecules identified as activators of PPM1A and PPM1B to elucidate their binding sites within these phosphatases. Furthermore, we investigated the effects of these compounds on osteoclast differentiation among RAW264 cells and lipid accumulation in 3T3-L1 adipocytes.

Academic Significance and Societal Importance of the Research Achievements

PPM1AおよびPPM1Bの活性化物質としてこれまでに同定されたglabridinとpisiferdiolが、細胞におけるこれらの酵素の生理機能を解明する上で、分子プローブとして有効であることが示された。また本研究により、これらの化合物によってPPM1AやPPM1Bの活性を制御することが、骨粗鬆症、肥満、糖尿病などの疾患の治療や予防に有効である可能性が示されたため、これらの酵素を標的とした薬剤や食品機能性成分の開発が期待される。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (60 results)

All 2019 2018 2017 2016 2015 Other

All Journal Article (17 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 16 results,  Open Access: 6 results) Presentation (42 results) (of which Int'l Joint Research: 9 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Isolation of a spirolactone norditerpenoid as a yeast Ca^2+ signal transduction inhibitor from Kuji amber and evaluation of its effects on PPM1A activity2019

    • Author(s)
      Shimizu Eisaku、Koshino Hiroyuki、Noro Aoi、Maruyama Miku、Shimoda Nozomu、Uesugi Shota、Ohnishi Motoko、Kimura Ken-ichi
    • Journal Title

      Fitoterapia

      Volume: 134 Pages: 290-296

    • DOI

      10.1016/j.fitote.2019.02.027

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A heterozygous deficiency in protein phosphatase Ppm1b results in an altered ovulation number in mice2019

    • Author(s)
      Ishii Naoki、Homma Takujiro、Watanabe Ren、Kimura Naoko、Ohnishi Motoko、Kobayashi Takayasu、Fujii Junichi
    • Journal Title

      Molecular Medicine Reports

      Volume: 19 Pages: 5353-5360

    • DOI

      10.3892/mmr.2019.10194

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A steroid alkaloid derivative 02F04 upregulates thymic stromal lymphopoietin expression slowly and continuously through a novel Gq/11-ROCK-ERK1/2 signaling pathway in mouse keratinocytes2019

    • Author(s)
      Weng Yan、Wang Jingwen、Yang Zhifu、Xi Miaomiao、Duan Jialin、Guo Chao、Yin Ying、Segawa Ryosuke、Moriya Takahiro、Yonezawa Takayuki、Cha Byung Yoon、Woo Je-Tae、Wen Aidong、Hirasawa Noriyasu
    • Journal Title

      Cellular Signalling

      Volume: 57 Pages: 58-64

    • DOI

      10.1016/j.cellsig.2019.01.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance2018

    • Author(s)
      Mitani Yuji、Satake Kazuhiro、Tsukamoto Megumi、Nakamura Ichiro、Kadioglu Onat、Teruya Toshiaki、Yonezawa Takayuki、Cha Byung-Yoon、Efferth Thomas、Woo Je-Tae、Nakagawa Hiroshi
    • Journal Title

      Phytomedicine

      Volume: 51 Pages: 112-119

    • DOI

      10.1016/j.phymed.2018.06.030

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Group 2 metal bis(arenecarbochalcogenoate)(crown ether) complexes: isolation and structural analysis2018

    • Author(s)
      Tatematsu Yoshiharu、Kato Shinzi、Nakata Norio、Ebihara Masahiro、Niyomura Osamu、Sugamata Koh、Yukimoto Mariko、Minoura Mao
    • Journal Title

      Dalton Transactions

      Volume: 47 Issue: 29 Pages: 9787-9794

    • DOI

      10.1039/c8dt01959b

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Group 13 metal carbochalcogenoato complexes: Synthesis, X-ray structure analysis, and reactions2018

    • Author(s)
      Nakata Norio、Kato Shinzi、Niyomura Osamu、Ebihara Masahiro
    • Journal Title

      Heteroatom Chemistry

      Volume: 29 Issue: 5-6

    • DOI

      10.1002/hc.21445

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 6-および7-ホスホノメチルナフタレン-1-カルボン酸の化学合成2018

    • Author(s)
      河村麻希,大西素子,堤内 要
    • Journal Title

      生物機能開発研究所紀要

      Volume: 18

    • NAID

      120006521134

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Harmine promotes molar root development via SMAD1/5/8 phosphorylation.2018

    • Author(s)
      Fujiwara N, Lee JW, Kumakami-Sakano M, Otsu K, Woo JT, Iseki S, Ota
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 497 Issue: 3 Pages: 924-929

    • DOI

      10.1016/j.bbrc.2017.12.062

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Induction of thymic stromal lymphopoietin by a steroid alkaloid derivative in mouse keratinocytes.2018

    • Author(s)
      Weng Y, Mizuno N, Dong J, Segawa R, Yonezawa T, Cha BY, Woo JT, Moriya T, Hiratsuka M, Hirasawa N.
    • Journal Title

      Int Immunopharmacol.

      Volume: 55 Pages: 28-37

    • DOI

      10.1016/j.intimp.2017.11.045

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of raw nepodin extraction from Rumex japonicus and R. obtusifolius and their DNA polymorphisms.2018

    • Author(s)
      Minami M, Mori T, Yonezawa T, Saito Y, Teruya T, Woo JT.
    • Journal Title

      J Nat Med.

      Volume: 72 Issue: 1 Pages: 369-374

    • DOI

      10.1007/s11418-017-1143-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acerogenin C from Acer nikoense exhibits a neuroprotective effect in mouse hippocampal HT22 cell lines through the upregulation of Nrf-2/HO-1 signaling pathways.2017

    • Author(s)
      Kim NT, Lee DS, Chowdhury A, Lee H, Cha BY, Woo JT, Woo ER, Jang JH
    • Journal Title

      Mol Med Rep

      Volume: 16 Issue: 2 Pages: 1537-1543

    • DOI

      10.3892/mmr.2017.6682

    • Related Report
      2017 Research-status Report
  • [Journal Article] Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation without altering fat mass in diet-induced obesity.2017

    • Author(s)
      Kim YJ, Choi MS, Woo JT, Jeong MJ, Kim SR, Jung UJ
    • Journal Title

      Mol Nutr Food Res.

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain.2016

    • Author(s)
      Kusano R, Fujita K, Shinoda Y, Nagaura Y, Kiyonari H, Abe T, Watanabe T, Matsui Y, Fukaya M, Sakagami H, Sato T, Funahashi JI, Ohnishi M, Tamura S, Kobayashi T.
    • Journal Title

      FEBS Lett.

      Volume: 590 Pages: 3606-3615

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Crystal Structure of 4-Methylbenzenecarbothioic Acid and Computational Investigations of Benzenecarbochalcogenoic Acids (C<sub>6</sub>H<sub>5</sub>COEH and C<sub>6</sub>H<sub>5</sub>CEOH, E = S, Se, Te)2016

    • Author(s)
      S. Kato, O. Niyomura, M. Ebihara, J.-D. Guo, S. Nagase.
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 89 Issue: 3 Pages: 361-368

    • DOI

      10.1246/bcsj.20150348

    • NAID

      130005137574

    • ISSN
      0009-2673, 1348-0634
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression.2015

    • Author(s)
      Kim HJ, Kim IS, Dong Y, Lee IS, Kim JS, Kim JS, Woo JT, Cha BY.
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 16 Issue: 4 Pages: 8772-8788

    • DOI

      10.3390/ijms16048772

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hyperpigmentation mechanism of methyl 3,5-di-caffeoylquinate through activation of p38 and MITF induction of tyrosinase.2015

    • Author(s)
      Kim HJ, Kim JS, Woo JT, Lee IS, Cha BY.
    • Journal Title

      Acta Biochim Biophys Sin

      Volume: 47 Issue: 7 Pages: 548-556

    • DOI

      10.1093/abbs/gmv040

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Honokiol, magnolol, and a combination of both compounds improve glucose metabolism in high-fat diet-induced obese mice2015

    • Author(s)
      Lee YS,Choi SS,Yonezawa T,Teruya T, Woo JT, Kim HJ, Cha BY
    • Journal Title

      Food Science and Biotechnology

      Volume: 24 Pages: 1467-1474

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] マルトビオン酸は卵巣摘出マウスの骨量減少を抑制する2019

    • Author(s)
      西尾彩花, 中村保奈美, 中川大, 渡辺章夫, 米澤貴之, 禹 済泰, 末廣大樹, 阿部秀飛, 深見健, 大西素子
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 骨代謝細胞に対するクベバコショウ由来リグナン化合物の作用2019

    • Author(s)
      米澤貴之、宇田初音、戸井田佳子、林忍弥、遠藤由貴、渡辺章夫、禹 済泰
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] タチバナ抽出物の皮膚炎症に対する抑制効果2019

    • Author(s)
      渡辺章夫、小林桃佳、佐藤美穂、米澤貴之、禹 済泰
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] オオバギ(Macaranga tanariusu)実由来抽出物及びその成分の生理活性2019

    • Author(s)
      夏目矩行、渡辺章夫、小塚隆造、米澤貴之、禹済泰、照屋俊明
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 多様性拡大抽出物から得られたメロテルペノイド化合物群の破骨細胞分化に対する作用2019

    • Author(s)
      米澤貴之,渡辺章夫,菊地晴久,大島吉輝,禹 済泰
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 種々のスルファニル基を有するイミダゾ[1,5-a]ピリジン誘導体の合成、構造および光物性2019

    • Author(s)
      伊藤 雅也,小原田まゆみ,坂本光輝,坂口 将大,饒村 修
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] イミダゾ[1,5-a]ピリジン骨格を有するセレノ炭酸エステルの合成、構造および錯形成能2019

    • Author(s)
      横関 翔,饒村 修
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 卵巣切除マウスにおけるマルトビオン酸の骨密度改善効果2018

    • Author(s)
      西尾彩花, 鵜飼容子, 山口青夏, 中川大, 渡辺章夫, 米澤貴之, 禹 済泰, 末廣大樹, 阿部秀飛, 深見健, 大西素子
    • Organizer
      食品科学工学会第65回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アリールジセレニドの合成とプロテインホスファターゼ阻害能2018

    • Author(s)
      澤本 佳佑 ・ 饒村 修 ・ 後藤 保 ・ 大西 素子
    • Organizer
      第49回中部化学関係学協会支部連合 秋期大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The inhibitory effects of Kaempferia parviflora extract on skin-inflammation2018

    • Author(s)
      Momoka Kobayashi, Akio Watanabe, Kyohei Inagaki, Takayuki Yonezawa, and Je-Tae Woo.
    • Organizer
      第4回 薬食国際カンファレンス (ICPF 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of dibenzylbutyrolactone lignans isolated from piper cubeba on glucose uptake in L6 myotube and 3T3-L1 preadipoeyte differetnation2018

    • Author(s)
      Yuki Endo, Akio Watanabe, Akari Furusawa, Takayuki Yonezawa, and Je-Tae Woo.
    • Organizer
      第4回 薬食国際カンファレンス (ICPF 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Inhibitory Effects of Toddaculin Isolated from Toddalia asiatica on Melanogeneses and Inflammation.2018

    • Author(s)
      Watanabe A, Kobayashi M, Endo Y, Toida Y, Nakagawa K, Yonezawa T ,Woo JT
    • Organizer
      The 31st Annual and International Meeting of Japanese Association for Animal Cell Technology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Kaempferia parviflora Extract on the Expression of Elastase and MMP-1 in Human Dermal Fibroblasts2018

    • Author(s)
      Kobayashi M, Watanabe A, Inagaki K, Deguchi Y, Woo JT, Yonezawa T
    • Organizer
      The 31st Annual and International Meeting of Japanese Association for Animal Cell Technology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of Cubebin and Hinokinin Isolated from Piper cubeba on Glycolipid Metabolism2018

    • Author(s)
      Endo Y, Watanabe A, Furusawa A, Koduka R, Deguchi Y, Woo JT, Yonezawa T
    • Organizer
      The 31st Annual and International Meeting of Japanese Association for Animal Cell Technology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cinnamic Acid Derivatives from Brazilian Green Propolis Promoted Osteoblast Differentiation and Suppressed Osteoclast Differentiation2018

    • Author(s)
      Deguchi Y, Kawakami T, Ogawa Y, Watanabe A, Jairo Kenupp Bastos, Yonezawa T, Woo JT
    • Organizer
      The 31st Annual and International Meeting of Japanese Association for Animal Cell Technology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 植物由来ポリメトキシフラボノイドの分析と多様な機能性2018

    • Author(s)
      渡辺章夫・禹済泰・米澤貴之
    • Organizer
      ノビレチン研究会 第2回学術研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Synthesis and Structure of Selenothiocarbamates2018

    • Author(s)
      Atsushi Shimozuma, Osamu Niyomura
    • Organizer
      6th Asian Network for Natural & Unnatural Materials
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] セレノ炭酸エステルの合成、構造および亜鉛塩との錯化検討2018

    • Author(s)
      横関 翔,饒村 修
    • Organizer
      第49回中部化学関係学協会支部連合秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] セラニル基およびスルファニル基を有するアゾベンゼン誘導体の合成と光異性化2018

    • Author(s)
      馬淵 啓太,桑原 準也,饒村 修
    • Organizer
      第49回中部化学関係学協会支部連合秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 置換アミノメチルピリジンと二酸化セレンとの反応2018

    • Author(s)
      加藤 貴幸,饒村 修
    • Organizer
      第49回中部化学関係学協会支部連合秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] スルファニル基を有するイミダゾ[1,5-a]ピリジン誘導体の合成と発光特性2018

    • Author(s)
      伊藤 雅也,坂口 将大,饒村 修
    • Organizer
      第49回中部化学関係学協会支部連合秋季大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] マルトビオン酸は破骨細胞分化を抑制する2018

    • Author(s)
      西尾彩花,鵜飼容子,山口青夏,末廣大樹,渡辺章夫, 米澤貴之, 禹 済泰,阿部秀飛,深見健,大西素子
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 種々のアリールセラニル基を有する化合物の合成とプロテインホスファ ターゼ阻害能2018

    • Author(s)
      澤本 佳佑,神谷 憲児,沢柳 大,依藤 知洋,饒村 修,加藤 友佳,大西 素子
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Research-status Report
  • [Presentation] PPM1 活性化物質は成熟脂肪細胞における脂肪滴の蓄積を抑制する2017

    • Author(s)
      鵜飼容子、佐竹一紘、中川大、木村賢一、大西素子
    • Organizer
      日本農芸化学会2017年度大
    • Place of Presentation
      京都女子大学(京都府,京都市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Research-status Report
  • [Presentation] 種々のイミダゾ[1,5-a]ピリジン骨格を有するセレノエステルの合成、構造およびその蛍光挙動2017

    • Author(s)
      沢柳 大,饒村 修
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶應義塾大学(神奈川県,横浜市)
    • Year and Date
      2017-03-18
    • Related Report
      2016 Research-status Report
  • [Presentation] プロテインSer/Thrホスファターゼ活性化物質の脂肪細胞における脂肪蓄積抑制効果2017

    • Author(s)
      西尾彩花,鵜飼容子,佐竹一紘,中川大,木村賢一,大西素子
    • Organizer
      第81回日本生化学会中部支部例会
    • Related Report
      2017 Research-status Report
  • [Presentation] マルトビオン酸の破骨細胞分化抑制効果2017

    • Author(s)
      西尾彩花,鵜飼容子,山口青夏,末廣大樹,阿部秀飛,深見健,大西素子
    • Organizer
      第30回日本動物細胞工学会2017年度大会
    • Related Report
      2017 Research-status Report
  • [Presentation] セレノエステル部位を持つピリジルイミダゾ[1,5-a]ピリジンを配位子とする錯体の合成と発光特性2017

    • Author(s)
      沢柳 大,饒村 修
    • Organizer
      第44回有機典型元素化学討論会
    • Related Report
      2017 Research-status Report
  • [Presentation] 「柑橘の機能性の新たな展開」ノビレチンの高純度製法と多様な生理機能2017

    • Author(s)
      禹済泰
    • Organizer
      第30回日本動物細胞工学会2017年度大会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] ブラジル産グリーンプロポリスから単離したバッカリンの抗糖尿病作用2017

    • Author(s)
      渡辺章夫、小塚隆造、出口有佑、ジャイロKenupp Bastos 米澤貴之、禹 済泰
    • Organizer
      第71回 日本栄養・食糧学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 沖縄産シークヮーサー及び黒ショウガ(ウコン)由来ポリメトキシーフラボノイドの多様な生理機能2017

    • Author(s)
      禹 済泰、米澤貴之、渡辺章夫、照屋俊明
    • Organizer
      第15回日本機能性食品医用学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] セレノカルボン酸イミダゾ[1,5-a]ピリジルエステルの合成、構造および亜鉛との錯化検討2016

    • Author(s)
      沢柳 大,饒村 修
    • Organizer
      第47回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      豊橋技術科学大学(愛知県,豊橋市)
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report
  • [Presentation] 抗CD98抗体依存性細胞融合阻害物質による破骨細胞分化の抑制2016

    • Author(s)
      鵜飼 容子, 青山 友果, 伊藤 守弘, 大西 素子
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県,仙台市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 脂肪細胞分化に対するプロポリス由来化合物の作用2016

    • Author(s)
      出口有佑,渡辺章夫,Jairo Kenupp Bastos,車炳允, 米澤 貴之,禹 済泰
    • Organizer
      日本食品科学工学会 第63回大会
    • Place of Presentation
      名城大学(愛知県,名古屋市)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Baccharin, Artepillin C, and Drupanin enhance adipocyte differentiation in 3T3-L1 cells2016

    • Author(s)
      Je-Tae Woo, Yusuke Deguchi, Akio Watanabe, Jairo Kenupp Bastos, Maria Palmira Daflon Gremiao, Franciane Marquele de Oliveira, Andresa Aparecida Berretta, Byung-Yoon Cha, Takayuki Yonezawa
    • Organizer
      Propolis Conference 2016
    • Place of Presentation
      Glasgow, UK
    • Year and Date
      2016-06-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Synthesis, Structure and Complexation Properties of Se-Imidazo[1,5-a]pyridyl Selenocarboxylates2016

    • Author(s)
      Osamu Niyomura, Dai Sawayanagi, Risa Mizuno
    • Organizer
      The 13th International Conference on the Chemistry of Selenium and Tellurium
    • Place of Presentation
      Gifu, Japan
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] プロテインホスファターゼ阻害剤による抗CD98抗体依存性細胞融合の阻害2016

    • Author(s)
      鵜飼 容子, 青山 友果, 伊藤 守弘, 大西 素子
    • Organizer
      第80回日本生化学会中部支部例会
    • Place of Presentation
      三重大学(三重県,津)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Research-status Report
  • [Presentation] 抗CD98依存性細胞融合に対するホスファターゼ阻害剤の効果2016

    • Author(s)
      鵜飼容子,青山友果,伊藤守弘,禹済泰,中川大,大西素子
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 癌遺伝子産物 PPM1D を阻害する低分子化合物2016

    • Author(s)
      岩崎 祐太,青山 友果,鵜飼 武寛,鵜飼 容子,饒村 修,大西 素子
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] プロテインSer/ThrホスファターゼWip1阻害剤の探索と生体基質を用いた阻害効果の解析2016

    • Author(s)
      岩崎祐太,青山友果,鵜飼武寛,饒村修,大西素子
    • Organizer
      第7回日本プロテインホスファターゼ研究会学術集会
    • Place of Presentation
      自然科学研究機構(愛知県岡崎市)
    • Year and Date
      2016-01-29
    • Related Report
      2015 Research-status Report
  • [Presentation] プロテインSer/ThrホスファターゼWip1阻害剤の同定とその性質2015

    • Author(s)
      鵜飼容子,青山友果,鵜飼武寛,饒村修,大西素子
    • Organizer
      第28回日本動物細胞工学会2015年度大会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 抗CD98依存性細胞融合阻害物質の探索2015

    • Author(s)
      鵜飼容子,伊藤守弘,禹済泰,中川大,大西素子
    • Organizer
      第10回トランスポーター研究会年会
    • Place of Presentation
      慶応大学(東京都港区)
    • Year and Date
      2015-06-21
    • Related Report
      2015 Research-status Report
  • [Remarks] 大西素子研究室 研究内容

    • URL

      https://www3.chubu.ac.jp/faculty/ohnishi_motoko/kenkyunaiyo

    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi