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Development of an experimental protocol and analytical method for functional magnetic resonance spectroscopy

Research Project

Project/Area Number 15K01857
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Brain biometrics
Research InstitutionAdvanced Telecommunications Research Institute International

Principal Investigator

Kochiyama Takanori  株式会社国際電気通信基礎技術研究所, 脳情報通信総合研究所, 研究員 (90380146)

Co-Investigator(Renkei-kenkyūsha) IMAMIZU Hiroshi  株式会社国際電気通信基礎技術研究所, 脳情報通信総合研究所・認知機構研究所, 所長 (30395123)
SADATO Norihiro  生理学研究所, 大脳皮質機能研究系, 教授 (00273003)
Research Collaborator SHIMADA Yasuhiro  (株)ATR-Promotions
FUJIMOTO Ichiro  (株)ATR-Promotions
TAMAOKI Ryohei  (株)ATR-Promotions
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords磁気共鳴スペクトロスコピー法 / MRS / 機能的磁気共鳴スペクトロスコピー法 / fMRS / 磁気共鳴画像 / MRI / 脳機能計測 / 非侵襲的脳活動計測
Outline of Final Research Achievements

Magnetic resonance spectroscopy (MRS) allows for noninvasive quantification of brain metabolism. Recently functional MRS (fMRS) is increasingly performed to study the dynamic change in brain metabolism and the neurometabolic correlates of behavioral measures or disease states. Spectral editing MRS techniques such as MEGA-PRESS sequence is commonly used to measure gamma-aminobutyric acid (GABA) and glutamate which is the main excitatory and excitatory neurotransmitter in the brain, respectively. However, there are problems of low signal-to-noise ratio and substantial variability in concentration estimates over time due to less than optimal measurement settings and analytical methods as well as their inherent low concentrations. In this work, we investigated the parameters for data acquisition and analysis to achieve high quality and reproducibility of neurometabolic concentrations and provided some methodological recommendations about these settings.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2018 2017 2015

All Journal Article (3 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Normal aging slows spontaneous switching in auditory and visual bistability2018

    • Author(s)
      Kondo, H. M. & Kochiyama, T.
    • Journal Title

      Neuroscience

      Volume: - Pages: 152-160

    • DOI

      10.1016/j.neuroscience.2017.04.040

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Individual differences in visual motion perception and neurotransmitter concentrations in the human brain.2017

    • Author(s)
      Takeuchi T, Yoshimoto S, Shimada Y, Kochiyama T, Kondo HM.
    • Journal Title

      Philosophical Transactions of The Royal Society B Biological Sciences

      Volume: 372 Issue: 1714 Pages: 1-7

    • DOI

      10.1098/rstb.2016.0111

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Neurotransmitter concentrations in the brain and visual motion assimilation/contrast2015

    • Author(s)
      Yoshimoto S, Takeuchi T, Shimada Y, Kochiyama T, Kondo HM
    • Journal Title

      基礎心理学研究

      Volume: 34(1) Pages: 201-202

    • Related Report
      2015 Research-status Report
  • [Presentation] Individual Differences in Visual Motion Perception and the Associated Excitatory and Inhibitory Neurotransmitter Concentrations in the Brain2015

    • Author(s)
      Takeuchi T, Yoshimoto S, Shimada Y, Kochiyama T, Kondo HM
    • Organizer
      OSA(Optical Society of America) Fall Vision Meeting
    • Place of Presentation
      San Jose, CA, USA
    • Year and Date
      2015-10-18
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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