White box testing of nanomedicines on a microfluidic device
| Project/Area Number |
15K04640
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nano/Microsystems
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| Research Institution | Toyo University |
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Principal Investigator |
Sasaki Naoki 東洋大学, 理工学部, 准教授 (30462691)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ナノ薬剤 / 血管透過性 / 共培養 / レーザー加工 / マイクロ流体デバイス / 血管 |
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| Outline of Final Research Achievements |
Nanoparticles have been widely utilized to deliver drugs from blood vessels to tumor tissues. In this study, we developed a microfluidic device to clarify nanoparticle characteristics required for efficient drug delivery. A consumer laser cutter was employed to fabricate the device. Tumor cells and vascular endothelial cells were co-cultured on a membrane-integrated microfluidic device. Permeation of nanoparticles through the endothelial monolayer increased in the presence of tumor cells.
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Report
(4 results)
Research Products
(7 results)
