| Project/Area Number |
15K04669
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Crystal engineering
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| Research Institution | Osaka Ohtani University |
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Principal Investigator |
Maki Syou 大阪大谷大学, 薬学部, 助教 (20502256)
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| Co-Investigator(Kenkyū-buntansha) |
萩原 政幸 大阪大学, 理学研究科, 教授 (10221491)
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| Co-Investigator(Renkei-kenkyūsha) |
ARATA Toshiaki 大阪市立大学, 大学院理学研究科・生物地球専攻系, 特任教授 (70151165)
FIJIWARA Seiji 明石工業高等専門学校, 機械工学科, 教授 (90335985)
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| Research Collaborator |
TANAKA Seiichi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | タンパク質結晶 / 結晶成長 / 磁気力ブースター / 磁気アルキメデス / 磁気浮上 / 無容器条件 / 磁気力 / タンパク質結晶化技術 / 磁気アルキメデス効果 / 対流 / 擬似無重力 / crystal growth / magnetic force / containerless condition / magnetic levitation / numerical computation / visualization / thermal properties |
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| Outline of Final Research Achievements |
This research aims at producing high quality protein crystals by means of realizing the condition of “containerless”, which is free from any stress or strain under the crystal growth. As required to control the crystals immediately after the nucleation, we utilized a technique of “magnetic force booster”. This technique was first licensed by the National Institute for Materials Science (NIMS) around 2000, afterwards, related rights were resigned. We drastically improved the shape and material of the booster, and 13 types of booster were newly developed. These boosters have a capability of fine-tuning of magnetic force, and can locally control over the horizontal component of magnetic force as well as the vertical one. We succeeded in keeping the containerless condition of protein crystallization without contacting the crystals to any solid bodies after the nucleation.
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