Optimization of Microwave-assisted Rapid Preparation of Highly Efficient Ion-exchange Monolithic Stationary Phases
| Project/Area Number |
15K05536
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Analytical chemistry
|
|---|
| Research Institution | Gifu University |
|---|
Principal Investigator |
Lim Lee Wah 岐阜大学, 工学部, 教授 (80377689)
|
|---|
| Project Period (FY) |
2015-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | マイクロ波合成 / 迅速調製法 / 有機ポリマーモノリス / イオン交換モノリス / ワンポット反応 / キャピラリーIC / 陰イオン交換モノリス / マイクロ波照射 / 有機ポリマー系モノリス / 陰イオン交換型モノリス / キャピラリーLC / 迅速・簡便調製法 / マイクロ波 / イオン交換型モノリス |
|---|
| Outline of Final Research Achievements |
In comparison to the conventional particulate-packed columns, monolithic columns possess higher porosity, and able to achieve high reaction and separation efficiency; therefore, they have attracted much attention as a separation, adsorption as well as catalytic supports. In preparing capillary-sized monolithic separation columns, in-situ polymerization method is generally used. As long as the present heating furnace method is used, it takes approximately 5 days to prepare a silica-based monolithic capillary column, and for the case of polymer-based monolithic capillary column, about 1 day is usually needed. In this study, rapid preparation of polymer-based monolithic capillary columns using microwave-assisted polymerization was optimized. The research was focused mainly on the preparation of high ion-exchange capacity monolithic columns, i.e. the amount of time taken during the column pretreatment, polymerization and surface chemical modification processes was shortened dramatically.
|
| Academic Significance and Societal Importance of the Research Achievements |
マイクロ波を利用した反応は，従来技術に比べて選択的，かつ数十分の一程度のエネルギーで，カラムの調製が可能な特色を有す。従来の加熱法では，モノリス調製の成功率がわずか30％であることに対して，マイクロ波照射を利用した場合，調製されたモノリスの80％が高い分離性能を示す。本研究は，分析システムの小型化によってシステムの消費電力が少なくなり，分析に必要な溶媒も数百分の一程度になるため，廃溶剤による環境負荷を大幅に低減することができる。
|
Report
(5 results)
Research Products
(62 results)
