| Project/Area Number |
15K06470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Composite materials/Surface and interface engineering
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| Research Institution | Tokyo Denki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
馬目 佳信 東京慈恵会医科大学, 医学部, 教授 (30219539)
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| Research Collaborator |
OHGOE Yasuharu
FUJIOKA Kouki
HIRATSUKA Masanori
TUBOI Hitomi
NAKAMORI Hideki
MASUDA Hideki
HONDA Hiroshi
MABUCHI Yasufumi
KATOUNO Junichi
KIDERA Shunta
SAITOU Kazuhiro
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | DLCコーティング / ドーピング / 骨芽細胞 / 生体親和性 / Zn徐放 / 元素ドーピング |
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| Outline of Final Research Achievements |
Diamond-like carbon (DLC) has a wide range of commercial applications and some types are known to be biologically stable. Zinc (Zn) has received attention because it enhances the production of alkaline phosphatase(ALP), which promotes bone calcification. Therefore, we manufactured a DLC that contains Zn (Zn-DLC) and can supply Zn to biological systems, as a potential biomaterial to enhance osteogenesis. We evaluated film crystallinity using Raman spectroscopy and measured the amount of released Zn using inductively coupled plasma mass spectrometry (ICP-MS). In addition, we evaluated the effects of Zn-DLC on osteogenesis in vitro. Osteoblasts cultured on Zn-DLC tended to show a greater area of calcification than those cultured on DLC, although no significant differences in ALP activity were observed. These results suggested the possibility that osteogenesis could be enhanced by the Zn that is released from Zn-DLC.
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