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Evaluation of the enhancement of osteogenesis by Zn-releasing diamond-like carbon film

Research Project

Project/Area Number 15K06470
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Composite materials/Surface and interface engineering
Research InstitutionTokyo Denki University

Principal Investigator

HIRAKURI Kenji  東京電機大学, 工学部, 教授 (60225505)

Co-Investigator(Kenkyū-buntansha) 馬目 佳信  東京慈恵会医科大学, 医学部, 教授 (30219539)
Research Collaborator OHGOE Yasuharu  
FUJIOKA Kouki  
HIRATSUKA Masanori  
TUBOI Hitomi  
NAKAMORI Hideki  
MASUDA Hideki  
HONDA Hiroshi  
MABUCHI Yasufumi  
KATOUNO Junichi  
KIDERA Shunta  
SAITOU Kazuhiro  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsDLCコーティング / ドーピング / 骨芽細胞 / 生体親和性 / Zn徐放 / 元素ドーピング
Outline of Final Research Achievements

Diamond-like carbon (DLC) has a wide range of commercial applications and some types are known to be biologically stable. Zinc (Zn) has received attention because it enhances the production of alkaline phosphatase(ALP), which promotes bone calcification. Therefore, we manufactured a DLC that contains Zn (Zn-DLC) and can supply Zn to biological systems, as a potential biomaterial to enhance osteogenesis. We evaluated film crystallinity using Raman spectroscopy and measured the amount of released Zn using inductively coupled plasma mass spectrometry (ICP-MS). In addition, we evaluated the effects of Zn-DLC on osteogenesis in vitro. Osteoblasts cultured on Zn-DLC tended to show a greater area of calcification than those cultured on DLC, although no significant differences in ALP activity were observed. These results suggested the possibility that osteogenesis could be enhanced by the Zn that is released from Zn-DLC.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (17 results) (of which Int'l Joint Research: 7 results,  Invited: 3 results) Book (1 results)

  • [Journal Article] Evaluation of the enhancement of osteogenesis by Zn-releasing diamond-like carbon film2017

    • Author(s)
      Katouno Junichi、Fujioka Kouki、Kidera Shunta、Mabuchi Yasufumi、Sato Keisuke、Ohgoe Yasuharu、Manome Yoshinobu、Hiratsuka Masanori、Nakamori Hideki、Masuda Hideki、Honda Hiroshi、Hirakuri Kenji
    • Journal Title

      Diamond and Related Materials

      Volume: 77 Pages: 131-136

    • DOI

      10.1016/j.diamond.2017.06.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ダイヤモンド状炭素(DLC)コーティングの高密着性プロセス法の開発2016

    • Author(s)
      平栗健二
    • Journal Title

      セラミック

      Volume: 51 Pages: 594-594

    • Related Report
      2016 Research-status Report
  • [Presentation] Characteristics of powdery state of DLC by oxygen plasma treatment2018

    • Author(s)
      Kyoichi Terai, Yuta Murayama, Keisuke Sato, Yasuharu Ohgoe, Jun Mizuno, Shuichi Shoji, Kenji Hirakuri
    • Organizer
      The International Conference on Engineering and Applied Science
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 簡易処理による低融点金属への高密着性DLC の作製2018

    • Author(s)
      中島 大地, 桒原 大樹, 安中 茂, 大越 康晴, 平栗 健二
    • Organizer
      第65回応用物理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] バイオマテリアル応用に向けたZn放出型DLC膜の特性評価2017

    • Author(s)
      木寺 俊太、上遠野 惇市、藤岡 宏樹、大越 康晴、佐藤 慶介、平塚 傑工、坪井 仁美、中村 秀樹、益田 秀樹、本田 宏志、馬目 佳信、平栗 健二
    • Organizer
      応用物理学会春季学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Prepation of powdery state of amorphous carbon by radio frequency plasma chemical vapor deposition2017

    • Author(s)
      Kyoichi Terai, Yasuharu Ohgoe, Kazuhide Ozeki, Keisuke Sato, Kenji Hirakuri
    • Organizer
      International Conference on Diamond and Carbon Materials
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Improvement of wear property for medical device by DLC coating2017

    • Author(s)
      Kengo Sakurai, Kyoichi Terai, Yuta Murayama, Keisuke Sato, Yasuharu Ohgoe, Jun Mizuno, Shuichi Shoji, Kenji Hirakuri
    • Organizer
      International Conference on Diamond and Carbon Materials
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 酸素プラズマ処理を施した粉体状DLCの基礎物性評価2017

    • Author(s)
      寺井 恭一,佐藤 慶介,平栗 健二
    • Organizer
      第31回ダイヤモンドシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 医療用デバイスへ向けた摺動性向上のためのDLCコーティング2017

    • Author(s)
      櫻井 賢吾,寺井 恭一,佐藤 慶介,平栗 健二
    • Organizer
      第31回ダイヤモンドシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] Zn含有DLCからのZn放出の溶媒による影響2017

    • Author(s)
      上遠野 惇一,佐藤 慶介,平栗 健二
    • Organizer
      第31回ダイヤモンドシンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨形成効果を持つZn含有DLCの膜構造評価2016

    • Author(s)
      上遠野惇市, 馬渕康史,藤岡宏樹,大越康晴,佐藤慶介,平塚傑工,中森秀樹,益田秀樹,本田宏志,馬目佳信,平栗健二
    • Organizer
      第30回ダイヤモンドシンポジウム
    • Place of Presentation
      東京大学(東京都目黒区)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] DLCの生体適合性とバイオ応用2016

    • Author(s)
      平栗健二
    • Organizer
      応用物理学会学術講演会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Enhancement of osteogenic on Zn releace with Zn doped DLC film coating2016

    • Author(s)
      Junichi Katono, Yasuharu Ohgoe, Koki Fujioka, Masanori Hiratsuka, Hitomi Tsuboi, Hideki Nakamori, Hideki Masuda, Hiroshi Honda, Yoshinobu Manome, Kenji Hirakuri
    • Organizer
      The 5th Asia-Pacific International Congress on Engineering & Natural Sciences
    • Place of Presentation
      Loisir Hotel, Naha (Okinawa, Japan)
    • Year and Date
      2016-08-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Structural Investigation of Zn Doped Diamond-Like Carbon Films2016

    • Author(s)
      Junichi Katouno, Yasufumi Mabuchi, Yasuharu Ohgoe, Keisuke Sato, Kouki Fujioka, Yoshinobu Manome, Masanori Hiratsuka, Hideki Nakamori, Hideki Masuda, Hiroshi Honda, Kenji Hirakuri
    • Organizer
      The 5th Asia-Pacific International Congress on Engineering & Natural Sciences
    • Place of Presentation
      Loisir Hotel, Naha (Okinawa, Japan)
    • Year and Date
      2016-08-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] DLCコーティングが創製するバイオマテリアル-高機能DLCコーティングの標準化-2016

    • Author(s)
      平栗健二
    • Organizer
      ニューダイヤモンドフォーラムDLC標準化特別委員会セミナー
    • Place of Presentation
      東京工業大学
    • Year and Date
      2016-03-04
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Zn徐放型DLC膜の骨形成促進効果の評価2015

    • Author(s)
      馬渕 康史, 上遠野惇市, 大越 康晴, 藤岡 宏樹, 佐藤 慶介, 平塚 傑工, 坪井 仁美, 中森 秀樹, 益田 秀樹, 本田 宏志, 馬目 佳信, 平栗 健二
    • Organizer
      第29回ダイヤモンドシンポジウム
    • Place of Presentation
      東京理科大学
    • Year and Date
      2015-11-17
    • Related Report
      2015 Research-status Report
  • [Presentation] 亜鉛含有DLC膜における亜鉛徐放量の制御2015

    • Author(s)
      上遠野惇市,馬渕康史,藤岡宏樹,大越康晴,佐藤慶介,平塚傑工,坪井仁美,中森秀樹,益田秀樹,本田宏志,馬目佳信,平栗健二
    • Organizer
      第76回応用物理学会秋季学術講演会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
  • [Presentation] Cytotoxicity of Zn-doped DLC for osteoblasts2015

    • Author(s)
      Yasufumi Mabuchi, Yasuharu Ohgoe, Kouki Fujioka, Keisuke Sato, Masanori Hiratsuka, Hitomi Tsuboi, Hideki Nakamori, Hideki Masuda, Hiroshi Honda, Yoshinobu Manome, Kenji Hirakuri
    • Organizer
      International Conference On Diamond and Carbon Materials
    • Place of Presentation
      Homburg, Germany
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of oxygen plasma treatment for various a-C:H films2015

    • Author(s)
      Y. Ohgoe, U. Kawachi, K. Hirakuri. A. Homma
    • Organizer
      The 5th International Symposium on Surface and Interface of Biomaterials (ISSIB 2015)
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2015-04-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] DLCの基礎と応用展開2016

    • Author(s)
      平栗健二
    • Total Pages
      263
    • Publisher
      シーエムシー出版
    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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