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Fabrication of film on the surface of Titanium alloy for the suppression of harmful metallic ion release and improvement of osseointegration

Research Project

Project/Area Number 15K06485
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Structural/Functional materials
Research InstitutionOsaka University

Principal Investigator

Miyabe Sayaka  大阪大学, 工学研究科, 助教 (50584132)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords金属バイオマテリアル / 電位制御 / チタン合金 / アルカリ加熱処理 / 骨親和性 / 表面処理 / ミクロ構造 / 為害元素低減 / 生体用金属材料 / 生体用医療材料 / 表面改質
Outline of Final Research Achievements

The Alkali and heat treatment on Ti and its alloys is one of the surface treatments to improve biocompatibility of metals and alloys applied as biomaterials. Conventionally, the process is performed without potential control. In the present study, the authors examined the alkali and heat treatment on Ti-6Al-4V alloy with potential pulse polarization, to improve osseointegration and to suppress the release of harmful metallic ions.Regardless of potential control, fine network structures of nano-scale were generated on the surface of alkali and heat treated samples. The surface layers were identified as sodium titanate. The network structure formed by potential pulse polarization was finer and thinner than that formed on the immersed sample. The V content of sample with potential pulse polarization was less than that of sample immersed in the NaOH solution without potential pulse polarization.

Academic Significance and Societal Importance of the Research Achievements

本研究は、通常電位制御を行わないアルカリ加熱処理中に方形波電位印加による電気化学的制御を行う、方形波パルス電位アルカリ加熱処理を実施することによって、電位が網目状酸化皮膜形成に及ぼす影響が検討された。本研究により、金属インプラント表面への高骨親和性皮膜形成および為害成分除去の両者が同時に達成されたことから、金属インプラントのの生体適合性向上および長期使用信頼性を向上させる表面処理として、金属インプラントの表面処理への適用が期待される。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Application of potential pulse polarization to the alkali and heat treatment on Ti-6Al-4V alloy.2016

    • Author(s)
      S. Miyabe, I. Suetake and S. Fujimoto
    • Journal Title

      Frontiers in Bioengineering and Biotechnology Conference Abstract: 10th World Biomaterials Congress (2016)

      Volume: ー

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] アルカリ加熱処理によりTi6Al4V合金表面に形成する皮膜形態の溶液による制御2017

    • Author(s)
      宮部さやか、末竹樹、藤本慎司
    • Organizer
      日本金属学会2017年春期講演大会(第160回)
    • Place of Presentation
      首都大学東京
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Fabrication of fine network structure on Ti-6Al-4V alloy by the Alkali and heat treatment in NaOH aqueous solution containing organic compound2017

    • Author(s)
      S. Miyabe, I. Suetake and S. Fujimoto
    • Organizer
      28th Annual Conference of the European Society for Biomaterials
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 電気化学プロセスを用いたアルカリ加熱処理によるTi6Al4V表面への酸化皮膜形成2016

    • Author(s)
      宮部さやか、末竹樹、藤本慎司
    • Organizer
      日本バイオマテリアル学会 シンポジウム2016
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2016-11-21
    • Related Report
      2016 Research-status Report
  • [Presentation] Ti6Al4V合金表面上でのアルカリ加熱処理による酸化被膜形成へ及ぼす電位制御の影響2016

    • Author(s)
      宮部さやか、末竹樹、藤本慎司
    • Organizer
      日本金属学会2016年秋期講演大会(第159回)
    • Place of Presentation
      大阪大学
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] アルカリ加熱処理によるTi6Al4V合金表面酸化皮膜の性状へ及ぼす電位制御の影響2016

    • Author(s)
      宮部さやか、末竹樹、藤本慎司
    • Organizer
      日本バイオマテリアル学会関西ブロック 第11 回関西若手研究発表会
    • Place of Presentation
      神戸大学
    • Year and Date
      2016-08-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Application of potential pulse polarization to the alkali and heat treatment on Ti-6Al-4V alloy2016

    • Author(s)
      S. Miyabe, I. Suetake and S. Fujimoto
    • Organizer
      10th World Biomaterials Congress
    • Place of Presentation
      Palais des congress de Montreal, Montreal, Canada
    • Year and Date
      2016-05-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Application of potential pulse polarization to the alkali and heat treatment on Ti-6Al-4V alloy2016

    • Author(s)
      S. Miyabe, I. Suetake and S. Fujimoto
    • Organizer
      10th World Biomaterials Congress
    • Place of Presentation
      Palais des congres de Montreal, Montreal, Canada
    • Year and Date
      2016-05-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] アルカリ加熱処によってTi6Al4V合金表面に形成する皮膜形態に及ぼすエチレングリコール添加の影響2015

    • Author(s)
      末竹樹、宮部さやか、藤本慎司
    • Organizer
      日本金属学会2015年秋期講演大会(第157回)
    • Place of Presentation
      九州大学(福岡県, 福岡市)
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] アルカリ加熱処理によりTi合金表面に形成する皮膜形態へのエチレングリコール添加の影響2015

    • Author(s)
      末竹樹、宮部さやか、藤本慎司
    • Organizer
      日本バイオマテリアル学会関西ブロック 第10 回関西若手研究発表会
    • Place of Presentation
      関西大学(大阪府, 吹田市)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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