Analysis of digestion characteristics of foods by developing a human duodenum digestion simulator equipped with peristalsis function

• Project/Area Number: 15K06590
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biofunction/Bioprocess
• Research Institution: National Agriculture and Food Research Organization
• Principal Investigator: KOBAYASHI Isao 国立研究開発法人農業・食品産業技術総合研究機構, 食品研究部門, 上級研究員 (70425552)
• Co-Investigator(Renkei-kenkyūsha): ICHIKAWA Sosaku 筑波大学, 生命環境系, 教授 (00292516)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 十二指腸 / 食品 / 消化 / ぜん動運動 / in vitro消化 / 混合 / 酵素反応 / シミュレーター / In vitro / 直接観察

Outline of Final Research Achievements

Evaluation of mixing and digestion behaviors of duodenum contents is important for understanding and controlling adsorption of nutritional components in the small intestine. In this research, we newly developed a human duodenum digestion simulator equipped with peristaltic motion and secretion of a digestive fluid on the duodenum wall. The use of this human duodenum digestion simulator was capable of quantitatively evaluating fundamental characteristics of fluid motion induced by the peristaltic motion as well as mixing and digestion of a simulated gastric chyme and a simulated digestive fluid.

Research Products

• [Presentation] ぜん動運動を具備したヒト十二指腸消化シミュレーターにおける内容物の混合特性の解析 (2018)
  • Author(s): Tachta ERLANGGA、神津博幸、溝口健作、小林功、市川創作
  • Organizer: 化学工学会第83年会