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Mechanisms of glial development

Research Project

Project/Area Number 15K06719
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionKeio University

Principal Investigator

Shimazaki Takuya  慶應義塾大学, 医学部(信濃町), 准教授 (00324749)

Research Collaborator TSUYAMA Jun  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords神経幹細胞 / グリア / 分化 / マーカー
Outline of Final Research Achievements

We attempted to develop a system to visualize glial-restricted progenitors (GRPs) and/or transition state of neural stem cell (NSC) differentiation into glia. We identified Kcnj16 which is an inward-rectifier type potassium channel as a marker for GRPs or glial differentiation of NSCs via expression profiling to identify genes which respond to the temporal changes of gliogenic potency of NSCs during development and in situ hybridization analysis of expression pattern of candidate genes during central nervous system development. Finally, it has been suggested that a reporter system which can recapitulate the expression pattern of Kcnj16 can be applicable to visualize GRPs or glial differentiation of NSCs.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (2 results)

  • [Journal Article] Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation2016

    • Author(s)
      Shimazaki T*, Okano H*
    • Journal Title

      npj Aging and Mechanisms of Disease

      Volume: 2 Issue: 1 Pages: 15014-15014

    • DOI

      10.1038/npjamd.2015.14

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vertebrate Neural Stem Cells: Development, Plasticity, and Regeneration.2016

    • Author(s)
      Shimazaki T*
    • Journal Title

      The Keio Journal of Medicine

      Volume: 65 Issue: 1 Pages: 1-15

    • DOI

      10.2302/kjm.2015-0005-ir

    • NAID

      130005138573

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MicroRNA-153 regulates the acquisition of gliogenic competence by neural stem cells.2015

    • Author(s)
      Tsuyama J, Bunt J, Richards LJ, Iwanari H, Mochizuki Y, Hamakubo T, Shimazaki T*, Okano H*
    • Journal Title

      Stem Cell Reports

      Volume: 5 Issue: 3 Pages: 365-377

    • DOI

      10.1016/j.stemcr.2015.06.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 神経幹/前駆細胞においてニューロン新生からグリア新生への切り替えを制御する調節因子2015

    • Author(s)
      津山  淳,島崎 琢也,岡野 栄之
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Research-status Report
  • [Presentation] 神経幹細胞のグリア分化能を制御する発生時期特異的な因子の同定2015

    • Author(s)
      津山  淳,島崎 琢也,岡野 栄之
    • Organizer
      第36回日本炎症・再生医学会
    • Place of Presentation
      虎ノ門ヒルズフォーラム(東京都港区)
    • Year and Date
      2015-07-21
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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