Analysis of parallel computing of the corticospinal pathways in the primates

Research Project

Project/Area Number	15K06749
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Nerve anatomy/Neuropathology
Research Institution	National Center of Neurology and Psychiatry
Principal Investigator	Umeda Tatsuya 国立研究開発法人国立精神・神経医療研究センター, 神経研究所モデル動物開発研究部, 室長 (90376723)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords	皮質脊髄路 / マカクサル / 一次運動野 / アデノ随伴ウイルス / premotor neuron
Outline of Final Research Achievements	We labeled premotor neurons of rats using recombinant rabies virus in the pilot experiments. However, the labeling efficiency is quite low so that we could not try to label premotor neurons in macaque monkeys using the same labeling method. We tried to detect a connection between cortical neurons and spinal interneurons using GFP reconstitution across synaptic partners (GRASP) but did not any signals arose from GRASP. We examined the distribution of projection fibers of neurons in the primary motor cortex of a macaque monkey. We detected labeled fibers in the primary somatosensory cortex, which is considered to function in conveying efference copy signals to the somatosensory system.