Elucidation of the mechanism of onset of schizophrenia caused by aberrant splicing and development of novel RNA medicine
| Project/Area Number |
15K06787
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Chukyo Gakuin University |
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Principal Investigator |
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| Research Collaborator |
MORIKAWA Tomomi 中京学院大学, 看護学部, 研究補助員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 選択的スプライシング / 統合失調症 / オリゴデンドロサイト / hnRNAA1 / hnRNPA1 / oligodendrocyte / alternative splicing / スプライシング / 精神疾患 |
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| Outline of Final Research Achievements |
Recently, aberrant regulation of alternative splicing (AS) of many psychiatric disease-related genes has been reported. Based on the results of oure study, it was found that the expression balance of hnRNPA1 is important for AS in the brain constitution process, and that disturbance causes aberrant differentiation of myelin sheath and neurons. This phenomenon was widely involved in factors that have already been pointed out in mental illness. On the other hand, novel AS products were present in hnRNPA1, and these were also revealed that the expression of thease variants were different in each organ. It was also suggested that the new AS variants forms a complex with the existing AS product and the difference in the expression balance of these AS product complexes may be involved in the differences in functions and fragility between various organs.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] MU314, a novel selective estrogen receptor modulator (SERM), improves estrogen-dependent depressive behaviors.2017
Author(s)
Izumo N, Ishibashi Y, Ono Y, Toho M, Sumino A, Kameyama T, Morikawa T, Shiba Y, Watanabe Y, Manabe T.
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Journal Title
Global Drugs and Therapeutics.
Volume: 2
Pages: 1-5
Related Report
Peer Reviewed / Open Access
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