• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the mechanism of onset of schizophrenia caused by aberrant splicing and development of novel RNA medicine

Research Project

Project/Area Number 15K06787
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionChukyo Gakuin University

Principal Investigator

Manabe Takayuki  中京学院大学, 看護学部, 教授 (90382283)

Research Collaborator MORIKAWA Tomomi  中京学院大学, 看護学部, 研究補助員
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords選択的スプライシング / 統合失調症 / オリゴデンドロサイト / hnRNAA1 / hnRNPA1 / oligodendrocyte / alternative splicing / スプライシング / 精神疾患
Outline of Final Research Achievements

Recently, aberrant regulation of alternative splicing (AS) of many psychiatric disease-related genes has been reported. Based on the results of oure study, it was found that the expression balance of hnRNPA1 is important for AS in the brain constitution process, and that disturbance causes aberrant differentiation of myelin sheath and neurons. This phenomenon was widely involved in factors that have already been pointed out in mental illness. On the other hand, novel AS products were present in hnRNPA1, and these were also revealed that the expression of thease variants were different in each organ. It was also suggested that the new AS variants forms a complex with the existing AS product and the difference in the expression balance of these AS product complexes may be involved in the differences in functions and fragility between various organs.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Invited: 2 results)

  • [Journal Article] Regulation and/or Repression of Cholinergic Differentiation of Murine Embryonic Stem Cells using RNAi Against Transcription Factor L3/Lhx8.2017

    • Author(s)
      Manabe T. and Wanaka A.
    • Journal Title

      Methods in Mol. Biol.

      Volume: 1622 Pages: 101-109

    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] MU314, a novel selective estrogen receptor modulator (SERM), improves estrogen-dependent depressive behaviors.2017

    • Author(s)
      Izumo N, Ishibashi Y, Ono Y, Toho M, Sumino A, Kameyama T, Morikawa T, Shiba Y, Watanabe Y, Manabe T.
    • Journal Title

      Global Drugs and Therapeutics.

      Volume: 2 Pages: 1-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potentiation of nerve growth factor-induced neurite outgrowth by a novel SERM, MU314, in PC12 cells.2017

    • Author(s)
      Izumo N, Ono Y, Inatomi C, Toho M, Katoh S, Tsuzuki S, Manabe T, Watanabe Y.
    • Journal Title

      Pharmacometrics.

      Volume: 92 Pages: 45-52

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fluvoxamine reverses estrogen-dependent decline in voluntary activities and decreased amygdala levels of serotonin in ovariectomized rats.2016

    • Author(s)
      Ishibashia Y, Izumoc N, Iwata K, Morikawa T, Kameyama T, Watanabe Y, *Manabe T and *Matsuzaki M.
    • Journal Title

      J. Brain Sci.

      Volume: 46 Pages: 5-9

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Fluvoxamine reverses estrogen-dependent decline in voluntary activities and decreased amygdala levels of serotonin in ovariectomized rats2016

    • Author(s)
      Yukiko Ishibashia, Nobuo Izumoc, Keiko Iwata, Tomomi Morikawa, Toshiki Kameyama, Yasuo Watanabe, Takayuki Manabee and Hideo Matsuzaki
    • Journal Title

      Journal of Brain Science

      Volume: -

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] グローバルなスプライシング抑制因子hnRNPA1 の発現量・発現様式の違いと神経ホメオスタシスの攪乱.2017

    • Author(s)
      森川智美、眞部孝幸.
    • Organizer
      日本薬学会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] スプライシング異常から解析する精神疾患-ヒトhnRNPA1 の新規isoform とその機能-2015

    • Author(s)
      眞部孝幸
    • Organizer
      金沢大学と北陸先端科学技術大学院大学 RNA 研究公開合同セミナー
    • Place of Presentation
      金沢大学
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
    • Invited

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi