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Identification of Vasohibin binding proteins and their mechanisms

Research Project

Project/Area Number 15K06821
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionTohoku University

Principal Investigator

SUZUKI YASUHIRO  東北大学, 加齢医学研究所, 助教 (60332277)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsVasohibin / がん悪性化 / チューブリン脱チロシン化 / SVBP / がん関連線維芽細胞 / がん微小環境 / 癌微小環境 / 血管新生 / チューブリン翻訳後修飾 / 癌関連線維芽細胞 / 脱チロシン化 / 腫瘍間質 / 微小管翻訳後修飾 / 癌悪性化
Outline of Final Research Achievements

In this study, I tried to identify the proteins associated with Vasohibin-2 (VASH2) and small vasohibin binding protein (SVBP), and analyzed their functions in tumor malignancy. I isolated and identified novel cell type specific proteins associated with VASH2 and/or SVBP using extracts of cancer cells, vascular endothelial cells, and mouse brain tissues. Point mutation analysis clarified important amino acid residues of VASH2 protein for binding to SVBP and for an alpha-tubulin detyrosinating activity of VASH2. Some of these mutants had dominant negative effects on the detyrosinating activity of endogenous VASH2 in cancer cells. Inhibition of VASH2 expression in cancer cells could attenuate the expansion of cancer-associated fibroblast in vivo and in vitro.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 1 results) Remarks (5 results)

  • [Journal Article] Requisite role of vasohibin-2 in spontaneous gastric cancer formation and accumulation of cancer-associated fibroblasts2017

    • Author(s)
      Yasuhiro Suzuki, Shuji Kitahara, Takuya Suematsu, Masanobu Oshima, Yasufumi Sato
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 12 Pages: 2342-2351

    • DOI

      10.1111/cas.13411

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 分泌性血管新生制御因子Vasohibin ファミリーの機能解析2018

    • Author(s)
      鈴木康弘、池田真教、菅野新一郎、佐藤靖史
    • Organizer
      平成29年度「先端モデル動物支援プラットフォーム成果発表会」
    • Related Report
      2017 Annual Research Report
  • [Presentation] VASHファミリー研究の最近の動向と今後の研究展開について2018

    • Author(s)
      鈴木康弘
    • Organizer
      第13回Vasohibin研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胃癌発症モデルマウスを用いた腫瘍発育・微小環境におけるVASH2の機能解析2017

    • Author(s)
      鈴木 康弘
    • Organizer
      第12回Vasohibin研究会
    • Place of Presentation
      ラフォーレ蔵王(宮城県・刈田郡蔵王町)
    • Year and Date
      2017-02-04
    • Related Report
      2016 Research-status Report
  • [Presentation] Analysis of the role of vasohibin-2 in spontaneous gastric cancer formation2016

    • Author(s)
      Yasuhiro Suzuki, Shuji Kitahara, Masanori Ikeda, Shin-ichiro Kanno, Masanobu Oshima, Yasufumi Sato
    • Organizer
      第24回日本血管生物医学会学術集会
    • Place of Presentation
      長崎ブリックホール(長崎県・長崎市)
    • Year and Date
      2016-12-08
    • Related Report
      2016 Research-status Report
  • [Presentation] The role of vasohibin-2 in spontaneous gastric cancer formation and modulation of tumor microenvironment2016

    • Author(s)
      Yasuhiro Suzuki, Shuji Kitahara, Masanobu Oshima, Yasufumi Sato
    • Organizer
      IVBM2016
    • Place of Presentation
      Sheraton Boston Hotel (Boston, USA)
    • Year and Date
      2016-10-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Vasohibin研究の新展開2016

    • Author(s)
      鈴木 康弘
    • Organizer
      第2回 血管生物若手研究会
    • Place of Presentation
      東北大学加齢医学研究所(宮城県・仙台市)
    • Year and Date
      2016-03-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 胃癌発症におけるVASH2の役割とVASHファミリー研究の新展開2016

    • Author(s)
      鈴木 康弘
    • Organizer
      第11回Vasohibin研究会
    • Place of Presentation
      ラフォーレ蔵王(宮城県・刈田郡蔵王町)
    • Year and Date
      2016-01-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Vasohibinファミリーの作用機序における新展開2015

    • Author(s)
      鈴木 康弘、乗田 理恵、池田 真教、菅野 新一郎、佐藤 靖史
    • Organizer
      第23回日本血管生物医学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Research-status Report
  • [Remarks] 東北大学 加齢医学研究所 腫瘍循環研究分野紹介

    • URL

      http://www.idac.tohoku.ac.jp/site_ja/admission-courses/overcoming-intractable-cancers/dept-vascular-biology/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 東北大学 加齢医学研究所 腫瘍循環研究分野ホームページ

    • URL

      http://www2.idac.tohoku.ac.jp/dep/vascbio/

    • Related Report
      2017 Annual Research Report 2015 Research-status Report
  • [Remarks] 東北大学加齢医学研究所腫瘍循環分野紹介

    • URL

      http://www.idac.tohoku.ac.jp/site_ja/admission-courses/overcoming-intractable-cancers/dept-vascular-biology/

    • Related Report
      2016 Research-status Report
  • [Remarks] 東北大学加齢医学研究所腫瘍循環分野ホームページ

    • URL

      http://www2.idac.tohoku.ac.jp/dep/vascbio/

    • Related Report
      2016 Research-status Report
  • [Remarks] 東北大学 加齢医学研究所 腫瘍循環研究分野紹介

    • URL

      http://www.idac.tohoku.ac.jp/ja/activities/research/vascular_biology/index.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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