Molecular mechanism of new cellular functions mediated by polysialic acid

• Project/Area Number: 15K06995
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Nagoya University
• Principal Investigator: SATO Chihiro 名古屋大学, 生物機能開発利用研究センター, 准教授 (10343211)
• Research Collaborator: Hane Masaya 名古屋大学, 生物機能開発利用研究センター, 研究員 ; Abe Chikara 名古屋大学, 大学院生命農学研究科, 学生 ; Mori Airi 名古屋大学, 大学院生命農学研究科, 学生
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ポリシアル酸 / 精神疾患 / 神経細胞接着分子 / ポリシアル酸転移酵素 / 統合失調症 / BDNF / FGF2 / ドーパミン / シアル酸 / 表面プラズモン共鳴法 / NCAM / 神経作用因子 / 分子間力相互作用

Outline of Final Research Achievements

Polysiali acid (polySia/PSA) is present in brain and is involved in learning, memory and social interaction. So far, we have been demonstrated that polySia is involved in brain functions not only due to its large exclusion volume but also due to molecule binding properties. In this research, we demonstrated that polySia chains show characteristic features towards molecule-binding properties via biosynthetic enzymes, ST8SIA2 and ST8SIA4.

Research Products

• [Journal Article] Polysialyltransferase ST8SIA2 and psychiatric disorders (2017)
  • Author(s): 羽根正弥、北島健、佐藤ちひろ
  • Journal Title: 生化学 Volume: 89 Issue: 5 Pages: 634-643
  • DOI: 10.14952/SEIKAGAKU.2017.890634
  • ISSN: 0037-1017
  • Year and Date: 2017-10-25
  • Peer Reviewed
• [Journal Article] Different properties of polysialic acids synthesized by the polysialyltransferases ST8SIA2 and ST8SIA4. (2017)
  • Author(s): Mori A, Hane M, Niimi Y, Kitajima K, Sato C.
  • Journal Title: Glycobiology Volume: 27 Issue: 9 Pages: 834-846
  • DOI: 10.1093/glycob/cwx057
  • Peer Reviewed
• [Journal Article] Chlorpromazine Increases the Expression of Polysialic Acid (PolySia) in Human Neuroblastoma Cells and Mouse Prefrontal Cortex. (2017)
  • Author(s): Abe C, Nishimura S, Mori A, Niimi Y, Yang Y, Hane M, Kitajima K, Sato C.
  • Journal Title: Int J Mol Sci. Volume: 18 Issue: 6 Pages: 1123-1123
  • DOI: 10.3390/ijms18061123
  • Peer Reviewed
• [Journal Article] Chemical synthesis and evaluation of a disialic acid-containing dextran polymer as an inhibitor of sialic acid binding immunoglobulin-like lectin, Siglec 7 (2017)
  • Author(s): Sho Yamaguchi, Atsushi Yoshimura, Yu Yasuda, Airi Mori, Hiroshi Tanaka, Takashi Takahashi, Ken Kitajima and Chihiro Sato
  • Journal Title: ChemBioChem Volume: - Issue: 13 Pages: 1194-1203
  • DOI: 10.1002/cbic.201600694
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Alpha-2 macroglobulin as a region-specific secretory protein in male reproductive tract, and its dynamics during sperm transit toward the female spermatheca in the blue crab. (2017)
  • Author(s): Senarai T, Vanichviriyakit R, Miyata S, Sato C, Sretarugsa P, Weerachatyanukul W, Kitajima K.
  • Journal Title: Mol Reprod Dev. Volume: 84 Issue: 7 Pages: 585-595
  • DOI: 10.1002/mrd.22817
  • Peer Reviewed
• [Journal Article] Altered Expression of Ganglioside GM3 Molecular Species and a Potential Regulatory Role During Myoblast Differentiation. (2017)
  • Author(s): Go S, Veillon L, Ciampa M, Mauri L, Sato C, Kitajima K, Prinetti A, Sonnino S, Inokuchi J.
  • Journal Title: J. Biol. Chem. Volume: 292 Issue: 17 Pages: 7040-7051
  • DOI: 10.1074/jbc.m116.771253
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Synthesis of end-functionalized glycopolymers containing α(2,8) disialic acids via π-allyl nickel catalyzed coordinating polymerization and their interaction with Siglec-7 (2017)
  • Author(s): Ohira, S.; Yasuda, Y.; Tomita, I.; Kitajima, K.; Takahashi, T.; Sato, C.; *Tanaka, H.
  • Journal Title: Chem. Commun. Volume: 53 Issue: 3 Pages: 553-556
  • DOI: 10.1039/c6cc07115e
  • Peer Reviewed
• [Journal Article] Diverse subcellular localizations of the insect CMP-sialic acid synthetases. (2017)
  • Author(s): Wu, D., Fujita, A., Hamaguchi, K., Delannoy, P., Sato, C., and Kitajima, K.
  • Journal Title: Glycobiology Volume: 4 Pages: 329-341
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Releasing Mechanism of Neurotrophic Factors via Polysialic Acid. (2017)
  • Author(s): Sato, C.
  • Journal Title: Vitamines and Hormones Volume: 104 Pages: 89-112
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Hsp70の酸性複合糖質結合活性の発見. 糖の意外な働き． (2017)
  • Author(s): 原田陽一郎、佐藤ちひろ、北島健
  • Journal Title: 化学と生物 Volume: 55, Pages: 22-26
  • NAID: 130006258162
  • Peer Reviewed
• [Journal Article] Effects of intronic single nucleotide polymorphisms (iSNPs) of a polysialyltransferase, ST8SIA2 gene found in psychiatric disorders on its gene products. (2016)
  • Author(s): Hane, M., Kitajima, K., and Sato, C.
  • Journal Title: Biochem Biophys Res Commun. Volume: 478 Pages: 1123-1129
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Relationship between ST8SIA2, polysialic acid and its binding molecules, and psychiatric disorders. (2016)
  • Author(s): Sato, C., Hane, M., and Kitajima, K.
  • Journal Title: Biochim Biophys Acta. Volume: 1860 Pages: 1739-1752
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The AMOR Arabinogalactan Sugar Chain Induces Pollen-Tube Competency to Respond to Ovular Guidance. (2016)
  • Author(s): Mizukami, A.G., Inatsugi, R., Jiao, J., Kotake, T., Kuwata, K., Ootani, K., Okuda, S., Sankaranarayanan, S., Sato, Y., Maruyama, D., Iwai, H., Garénaux, E., Sato, C., Kitajima, K., Tsumuraya, Y., Mori, H., Yamaguchi, J., Itami, K., Sasaki, N., and Higashiyama, T.
  • Journal Title: Curr Biol. Volume: 26 Pages: 1091-1097
  • Peer Reviewed / Open Access
• [Journal Article] Protective effects of polysialic acid on proteolytic cleavage of FGF2 and proBDNF/BDNF. (2015)
  • Author(s): Hane M, Matsuoka S, Miyata S. Kitajima K and Sato C.
  • Journal Title: Glycobiology Volume: 10 Pages: 1112-24
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Advanced technologies in sialic acid and sialoglycoconjugate anaysis. (2015)
  • Author(s): Kitajima K, Varki N, Sato C
  • Journal Title: Top Curr Chem. Volume: 367 Pages: 75-103
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Sulfatide-Hsp70 interaction promotes Hsp70 clustering and stabilizes binding to unfolded protein. (2015)
  • Author(s): Harada Y, Sato C, Kitajima K.
  • Journal Title: Biomolecules. Volume: 5 Pages: 958-73
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ganglioside contained in the neuronal tissue-enriched acidic protein of 22 kDa (NAP-22) fraction prepared from the detergent-resistant membrane microdomain of rat brain inhibits the phosphatase activity of calcineurin (2015)
  • Author(s): Kobayashi Y, da Silva R, Kumanogoh H, Miyata S, Sato C, Kitajima K, Nakamura S, Morita M, Hayashi F, Maekawa S.
  • Journal Title: J Neurosci Res. Volume: 93 Pages: 1462-70
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Discovery, primary and crystal structures, and capacitation-related properties of a prostate-derived heparin-binding protein WGA16 from boar sperm. (2015)
  • Author(s): Garénaux E, Kanagawa M, Tsuchiyama T, Hori K, Kanazawa T, Goshima A, Chiba M, Yasue H, Ikeda A, Yamaguchi Y, Sato C, and Kitajima K.
  • Journal Title: J. Biol. Chem. Volume: 290 Pages: 5484-5501
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Rapid trimming of cell surface polySia by exovesicular sialidase triggers release of preexisting surface neurotrophin. (2015)
  • Author(s): Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OM, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K, and Sato C.
  • Journal Title: J. Biol. Chem. Volume: 290 Pages: 13202-14
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 動物由来シアル酸9-リン酸合成酵素(SPS)の性質の解析． (2018)
  • Author(s): 石川寛菜*、佐藤ちひろ、北島健．
  • Organizer: 日本農芸化学会2018年度名古屋大会
• [Presentation] α2,8-シアル酸転移酵素(ST8SIA)の生合成するエピトープと抗シアル酸抗体の特異性の解析． (2018)
  • Author(s): 津田佳奈*、高橋映莉乃*、北島健、佐藤ちひろ．
  • Organizer: 日本農芸化学会2018年度名古屋大会
• [Presentation] 酸性糖鎖ポリシアル酸の新機能の発見とその応用展開. (2017)
  • Author(s): 佐藤ちひろ.
  • Organizer: 日本農芸化学会2017年度京都大会
  • Place of Presentation: 京都
  • Year and Date: 2017-03-17
  • Invited
• [Presentation] 哺乳動物細胞におけるポリシアル酸転移酵素の活性発現制御機構の解析. (2017)
  • Author(s): 石原幸奈、羽根正弥、北島健、佐藤ちひろ．
  • Organizer: 日本農芸化学会2017年度京都大会
  • Place of Presentation: 京都
  • Year and Date: 2017-03-17
• [Presentation] Genetic and environmental factors influence the ex- pression of polysialic acid in brain. (2017)
  • Author(s): Chihiro Sato
  • Organizer: 24th International Symposium on Glycoconjugates
  • Int'l Joint Research / Invited
• [Presentation] Biochemical analyses of polysialic acid synthesized by the polysialyltransferase ST8SIA2 found in psychiatric disorder patients. (2017)
  • Author(s): Chihiro Sato and Ken Kitajima
  • Organizer: 1st International Conference on the Glycobiology of Nervous System
  • Int'l Joint Research / Invited
• [Presentation] Attractive field of polySia synthesized by polysialyltransfreases, ST8SIA2 and ST8SIA4. (2017)
  • Author(s): Chihiro Sato
  • Organizer: 4th Latin American Congress of Glycobiology
  • Int'l Joint Research / Invited
• [Presentation] 酸性糖鎖ポリシアル酸の新機能の発見とその応用展開． (2017)
  • Author(s): 佐藤ちひろ
  • Organizer: 日本農芸化学会中部支部第179回例会
  • Invited
• [Presentation] Analysis of relationship between polysialyltransferases and malignant phenotype of the B16 mouse melanoma cell. (2017)
  • Author(s): Erino Araki, Kana Tsuda, Ken Kitajima, Chihiro Sato
  • Organizer: 24th International Symposium on Glycoconjugates
  • Int'l Joint Research
• [Presentation] Occurrence and biosynthesis of sulfated sialic acids in mammals. (2017)
  • Author(s): Nursah Ertunc, Thanyaluck Phitak, Hiroshi Fujita, Chihiro Sato, Ken Kitajima.
  • Organizer: 24th International Symposium on Glycoconjugates
  • Int'l Joint Research
• [Presentation] Mechanism of uptake of deaminoneuraminic acid (KDN) in mammalian cells. (2017)
  • Author(s): Yuya Iwaki, Chihiro Sato, Ken Kitajima.
  • Organizer: 24th International Symposium on Glycoconjugates
  • Int'l Joint Research
• [Presentation] Unique properties of polyvalent disialic acid-linked dextran toward the sialic acid-binding lectin siglec-7. (2017)
  • Author(s): Yoshimura, Yu Yasuda, Airi Mori, Hiroshi Tanaka, Ken Kitajima, Chihiro Sato
  • Organizer: 24th International Symposium on Glycoconjugates
  • Int'l Joint Research
• [Presentation] Different properties of polysialic acids synthesized by either or both of the polysialyltransferases ST8SIA2 and ST8SIA4. (2017)
  • Author(s): Airi Mori*, Masaya Hane**, Ken Kitajima, Chihiro Sato
  • Organizer: 24th International Symposium on Glycoconjugates
  • Int'l Joint Research
• [Presentation] Effects of chlorpromazine, an anti-schizophrenia reagent, on the expression of the polysialic acid in human neuroblastoma cells and mouse brains. (2017)
  • Author(s): Chikara Abe, Saki Nishimura, Airi Mori, Yuki Niimi, Yi Yang, Masaya Hane, Ken Kitajima, Chihiro Sato
  • Organizer: 24th International Symposium on Glycoconjugates
  • Int'l Joint Research
• [Presentation] Incorporation mechanism of deaminoneuraminic acid (KDN) in mammalian cells. (2017)
  • Author(s): Yuya Iwaki, Chihiro Sato, Ken Kitajima.
  • Organizer: 1st International Conference on the Glycobiology of Nervous System
  • Int'l Joint Research
• [Presentation] Discovery of exosomal glycosidases in microglia and macrophages cells. (2017)
  • Author(s): Atsushi Yoshimura*, Mizuki Sumida**, Ken Kitajima, Chihiro Sato.
  • Organizer: 1st International Conference on the Glycobiology of Nervous System
  • Int'l Joint Research
• [Presentation] Establishment of the evaluation method for the repulsive field displayed by polysialic acids. (2017)
  • Author(s): Airi Mori*, Masaya Hane**, Ken Kitajima, Chihiro Sato.
  • Organizer: 1st International Conference on the Glycobiology of Nervous System
  • Int'l Joint Research
• [Presentation] Chlorpromazine increases the expression of polySia in human neuroblastoma cells and mouse prefrontal cortex. 1st International Conference on the Glycobiology of Nervous System (2017)
  • Author(s): Chikara Abe*, Saki Nishimura**, Airi Mori*, Yuki Niimi**, Yi Yang*, Masaya Hane**, Ken Kitajima, Chihiro Sato.
  • Organizer: 1st International Conference on the Glycobiology of Nervous System
  • Int'l Joint Research
• [Presentation] Quantitative analysis of sialic acids in Medaka embryos during early development. (2017)
  • Author(s): Bo Fu*, Chihiro Sato, Ken Kitajima
  • Organizer: 第81回生化学会中部支部例会・シンポジウム
• [Presentation] 脊椎動物CMP-シアル酸合成酵素の細胞内動態の解析. (2017)
  • Author(s): 荒川広夢*、Wu Di、藤田明子**、佐藤ちひろ、北島 健.
  • Organizer: 第81回生化学会中部支部例会・シンポジウム
• [Presentation] 脊椎動物脳におけるポリシアル酸の量的質的変動の解析. (2017)
  • Author(s): 楊溢*、森愛理*、北島健、佐藤ちひろ.
  • Organizer: 第81回生化学会中部支部例会・シンポジウム
• [Presentation] ジシアル酸含有デキストランは Siglec-7 のリガンド結合を阻害する. (2017)
  • Author(s): 吉村淳*、安田優**、森愛理*、田中浩士、北島健、佐藤ちひろ.
  • Organizer: 第81回生化学会中部支部例会・シンポジウム
• [Presentation] 筋分化に伴う GM3 分子種変化の発見とその分子機構の解明． (2017)
  • Author(s): 郷詩織*、郷慎司**、べイロン・ルーカス、井ノ口仁一、佐藤ちひろ、北島健．
  • Organizer: 第36回日本糖質学会年会
• [Presentation] ポリシアル酸転移酵素 ST8SIA2 と ST8SIA4が合成するポリシアル酸の構造と性質． (2017)
  • Author(s): 森愛理*、羽根正弥**、北島健、佐藤ちひろ.
  • Organizer: 第36回日本糖質学会年会
• [Presentation] 多価ジシアル酸結合デキストランのシアル酸認識レクチン Siglec-7 に 対する特異な結合性の解析． (2017)
  • Author(s): 吉村淳*、安田優*、森愛理*、田中 浩士、北島健、佐藤ちひろ．
  • Organizer: 第36回日本糖質学会年会
• [Presentation] マウスメラノーマ細胞におけるポリシアル酸転移酵素の癌形質への影響． (2017)
  • Author(s): 荒木映莉乃*、津田佳奈*、北島健、佐藤ちひろ．
  • Organizer: 第36回日本糖質学会年会
• [Presentation] 急性ストレスとシアル酸投与が及ぼすマウス脳内における polySia-NCAM の発現変動． (2017)
  • Author(s): 阿部智佳羅*、羽根正弥**、北島健、佐藤ちひろ．
  • Organizer: 第36回日本糖質学会年会
• [Presentation] シアル酸発現が抑制されるCMP-シアル酸合成酵素の2種類の点変異体メダカは異なる運命をもつ (2017)
  • Author(s): 北島健、呉迪、藤田明子**、安川裕子**、谷口善仁、亀井保博、佐藤ちひろ．
  • Organizer: 日本動物学会第88回富山大会
• [Presentation] ニワトリ精子の脂質ラフトに対する抗体が精子運動性に及ぼす効果の解析． (2017)
  • Author(s): 是枝達也*、鈴木英里子**、大森保成、佐藤ちひろ、北島健．
  • Organizer: 日本動物学会第88回富山大会
• [Presentation] マウス精管上の精子成熟過程におけるMFG-E8とCD52の取込み機構の解析． (2017)
  • Author(s): マグー・シリラク、金沢尊**、大島健司、松田幹、佐藤ちひろ、北島健．
  • Organizer: 日本動物学会第88回富山大会
• [Presentation] 筋分化過程におけるGM3分子種変化の分子機構解析 (2017)
  • Author(s): 郷詩織*、郷慎司**、Lucas Veillon、井ノ口仁一、佐藤ちひろ、北島健
  • Organizer: 第5回 若手による骨格筋細胞研究会
• [Presentation] ポリシアル酸転移酵素ST8SIA2とST8SIA4が合成するポリシアル酸の構造と性質． (2017)
  • Author(s): 森愛理*、羽根正弥**、北島健、佐藤ちひろ．
  • Organizer: 第14回若手の力フォーラム
• [Presentation] 急性ストレスとシアル酸投与が及ぼすマウス脳内におけるpolySia-NCAMの発現変動． (2017)
  • Author(s): 阿部智佳羅*、羽根正弥**、北島健、佐藤ちひろ．
  • Organizer: 第14回若手の力フォーラム
• [Presentation] ジシアル酸結合デキストランのシアル酸認識レクチンSiglec-7に対する特異な結合性の解析 (2017)
  • Author(s): 吉村淳*、安田優**、森愛理*、田中浩士、北島健、佐藤ちひろ．
  • Organizer: 第14回若手の力フォーラム
• [Presentation] ポリシアル酸転移酵素のマウスメラノーマにおける癌形質への関与． (2017)
  • Author(s): 荒木映莉乃*、津田佳奈*、北島健、佐藤ちひろ．
  • Organizer: 第14回若手の力フォーラム
• [Presentation] 進化的観点からみた脊椎動物脳におけるポリシアル酸の量的質的変動の解析． (2017)
  • Author(s): 楊溢*、森愛理*、北島健、佐藤ちひろ．
  • Organizer: 第14回若手の力フォーラム
• [Presentation] ポリシアル酸転移酵素ST8SIA2のヒト特異的変異の進化的影響ポリシアル酸構造と機能への影響 (2017)
  • Author(s): 羽根正弥**、Michael Vaill、内藤裕子、Sandra Diaz、Leela R.L. Davies、北島健、Ajit Varki、佐藤ちひろ．
  • Organizer: 第90回日本生化学会大会
• [Presentation] ポリシアル酸転移酵素STXおよびPSTのマウスメラノーマにおける癌形質への関与． (2017)
  • Author(s): 荒木映莉乃*、津田佳奈*、北島健、佐藤ちひろ．
  • Organizer: 第90回日本生化学会大会
• [Presentation] 脊椎動物CMP-シアル酸合成酵素の細胞内動態の解析． (2017)
  • Author(s): 川広夢*、Wu Di、藤田明子**、佐藤ちひろ、北島健．
  • Organizer: 第90回日本生化学会大会
• [Presentation] 哺乳類細胞におけるデアミノノイラミン酸(KDN)の単糖およびオリゴマーの取込機構の解析． (2017)
  • Author(s): 岩木佑弥*、佐藤ちひろ、北島健．
  • Organizer: 第90回日本生化学会大会
• [Presentation] CMP-シアル酸合成酵素遺伝子のTILLING法によるメダカ変異体の取得とその解析． (2017)
  • Author(s): 北島健、呉迪、藤田明子**、谷口善仁、亀井保博、佐藤ちひろ．
  • Organizer: 第90回日本生化学会大会
• [Presentation] ポリシアル酸修飾された神経細胞接着分子か持つ反接着機能の新たな評価法の確立. (2016)
  • Author(s): 森愛理、新美百希、羽根正弥、北島健、佐藤ちひろ .
  • Organizer: 第13回若手の力フォーラム
  • Place of Presentation: 岐阜
  • Year and Date: 2016-11-26
• [Presentation] 哺乳類細胞におけるポリシアル酸転移酵素の性質の解析. (2016)
  • Author(s): 石原幸奈、羽根正弥、北島健、佐藤ちひろ.
  • Organizer: 第13回若手の力フォーラム
  • Place of Presentation: 岐阜
  • Year and Date: 2016-11-26
• [Presentation] α2,8シアル酸転移酵素(ST8SIA)が生合成するシアロ糖鎖構の免疫化学的解析. (2016)
  • Author(s): 津田佳奈、高橋映莉乃、羽根正弥、北島健、佐藤ちひろ.
  • Organizer: 第13回若手の力フォーラム
  • Place of Presentation: 岐阜
  • Year and Date: 2016-11-26
• [Presentation] 抗精神疾患薬投与条件下におけるヒト神経細胞およびマウス脳のポリシアル酸構の変動解析. (2016)
  • Author(s): 阿部智佳羅、西村紗希、羽根正弥、北島健、佐藤ちひろ.
  • Organizer: 第13回若手の力フォーラム
  • Place of Presentation: 岐阜
  • Year and Date: 2016-11-26
• [Presentation] Regulation of quality and quantity of polysialic acid by ST8SIA2/STX: Lessons from its SNPs reported in psychiatric diseases. (2016)
  • Author(s): Chihiro Sato.
  • Organizer: The Sialoglyco 2016 conference
  • Place of Presentation: Santa Barbara, USA
  • Year and Date: 2016-11-14
  • Int'l Joint Research / Invited
• [Presentation] Establishment of a new method for evaluating the repulsive function of polySia-NCAM. (2016)
  • Author(s): Airi Mori, Yuki Niimi, Masaya Hane, Ken Kitajima, and Chihiro Sato.
  • Organizer: The Sialoglyco 2016 conference
  • Place of Presentation: Santa Barbara, USA
  • Year and Date: 2016-11-14
• [Presentation] ミクログリアが放出するエキソソームに含まれるシアリダーゼの同定とその機能解析. (2016)
  • Author(s): 佐藤ちひろ
  • Organizer: 第89回日本生化学会大会シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
  • Invited
• [Presentation] 精神疾患患者に見出されたST8SIA2/STXのiSNPおよびrSNPの生化学的解析. (2016)
  • Author(s): 羽根正弥、早川敏之、北島健、佐藤ちひろ.
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
• [Presentation] 抗α2,8-結合シアル酸認識抗体を用いたST8SIAによって生合成される細胞表面シアル酸エピトープの解析. (2016)
  • Author(s): 津田佳奈、高橋映莉乃、羽根正弥、北島健、佐藤ちひろ.
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台
  • Year and Date: 2016-09-25
• [Presentation] 抗精神疾患薬投与条件下におけるヒト神経細胞およびマウス脳のポリシアル酸構造の変動解析. (2016)
  • Author(s): 阿部智佳羅、西村紗希、羽根正弥、北島健、佐藤ちひろ
  • Organizer: 第35回日本糖質学会年会
  • Place of Presentation: 高知
  • Year and Date: 2016-09-01
• [Presentation] 統合失調症患者に見出されたST8SIA2/STX のrSNPが及ぼす影響とそのメカニズムの解析 (2016)
  • Author(s): 羽根正弥、早川敏之、北島健、佐藤ちひろ
  • Organizer: 第35回日本糖質学会年会
  • Place of Presentation: 高知
  • Year and Date: 2016-09-01
• [Presentation] 神経細胞接着分子のポリシアル酸修飾の新しい制御機構の存在. (2016)
  • Author(s): 森愛理、内村健治、北島健、佐藤ちひろ.
  • Organizer: 第80回生化学会中部支部例会・シンポジウム
  • Place of Presentation: 津、三重
  • Year and Date: 2016-05-21
• [Presentation] Polysialic acid as an attractant for bioactive compounds. (2016)
  • Author(s): Chihiro Sato.
  • Organizer: Frontiers in Sialic Acid Research Conference: From Structural Diversity to Functional Glycobiology
  • Place of Presentation: Bad Lauterberg, Germany.
  • Year and Date: 2016-04-23
  • Int'l Joint Research / Invited
• [Presentation] Effects of SNPs genetic variations in the ST8SIA2 gene from the psychiatric disorder patients on the expression and functions of polysialic acid. (2016)
  • Author(s): Chihiro Sato
  • Organizer: The Netherlands Joint Seminar 2016
  • Place of Presentation: Leiden, The Netherlands.
  • Year and Date: 2016-04-19
  • Int'l Joint Research / Invited
• [Presentation] Effects of the genetic alterations of ST8SIA2/STX reported from psychiatric diseases on the structure and functions of polysialic acid. (2016)
  • Author(s): Chihiro Sato
  • Organizer: 3rd International symposium on Glyco-neuroscience
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2016-01-14
  • Int'l Joint Research / Invited
• [Presentation] Brain-region specific change of polysialic acid (polySia) on NCAM under acute stress conditions. Same as above. (2016)
  • Author(s): Chikara Abe, Masaya Hane, Sinji Miyata, Ken Kitajima, and Chihiro Sato
  • Organizer: 3rd International symposium on Glyco-neuroscience
  • Place of Presentation: Awaji, Hyogo, Japan
  • Year and Date: 2016-01-14
  • Int'l Joint Research
• [Presentation] 五島亜実、山川奈緒、安田優、田中浩士、宮田真路、北島健、佐藤ちひろ (2015)
  • Author(s): 免疫細胞におけるSiglec-7の新規リガンド結合部位による免疫応答制御
  • Organizer: 第88回日本生化学会大会・第38回日本分子生物学会年会合同大会
  • Place of Presentation: 第88回日本生化学会大会・第38回日本分子生物学会年会合同大会
  • Year and Date: 2015-12-01
• [Presentation] ポリシアル酸転移酵素STX/ST8SIA2とPST/ST8SIA4は異なるポリシアル酸構造および神経作用因子結合性を生み出す． (2015)
  • Author(s): 新美百希、羽根正弥、北島健、佐藤ちひろ
  • Organizer: 第88回日本生化学会大会・第38回日本分子生物学会年会合同大会
  • Place of Presentation: 第88回日本生化学会大会・第38回日本分子生物学会年会合同大会
  • Year and Date: 2015-12-01
• [Presentation] 高次脳機能や精神疾患に関与するポリシアル酸構造の新機能 (2015)
  • Author(s): 佐藤ちひろ
  • Organizer: 日本薬学会東海支部特別講演会
  • Place of Presentation: 静岡県立大学
  • Year and Date: 2015-10-19
  • Invited
• [Presentation] Effects of psychiatric disorders-related intronic single nucleotide polymorphisms (iSNPs) of the polysialyltransferase ST8SIA2/STX gene (2015)
  • Author(s): Masaya Hane, Ken Kitajima, Chihiro Sato
  • Organizer: 23rd International Symposium on Glycoconjugates (Glyco23)
  • Place of Presentation: Split, Croatia
  • Year and Date: 2015-09-15
  • Int'l Joint Research
• [Presentation] Structural and functional changes of polysialic acid related with genetic alterations of ST8SIA2/STX in psychiatric diseases. (2015)
  • Author(s): Chihiro Sato
  • Organizer: 23rd International Symposium on Glycoconjugates (Glyco23)
  • Place of Presentation: Split, Croatia
  • Year and Date: 2015-09-15
  • Int'l Joint Research / Invited
• [Presentation] マウスの急性ストレス条件下における脳内ポリシアル酸構造の領域特異的変動の解析 (2015)
  • Author(s): 阿部智佳羅, 羽根正弥, 宮田真路, 北島健, 佐藤ちひろ
  • Organizer: 第34回日本糖質学会年会
  • Place of Presentation: 東京大学
  • Year and Date: 2015-07-31
• [Presentation] 哺乳類細胞の内在性ポリシアル酸転移酵素の性質の解析 (2015)
  • Author(s): 石原幸奈, 羽根正弥, 宮田真路, 北島 健, 佐藤ちひろ
  • Organizer: 第34回日本糖質学会年会
  • Place of Presentation: 東京大学
  • Year and Date: 2015-07-31
• [Presentation] ポリシアル酸転移酵素STX/ST8SIA2とPST/ST8SIA4のポリシアル酸生合成能の解析 (2015)
  • Author(s): 新美百希, 羽根正弥, 松岡修平, 宮田真路, 北島健, 佐藤ちひろ
  • Organizer: 第34回日本糖質学会年会
  • Place of Presentation: 東京大学
  • Year and Date: 2015-07-31
• [Presentation] 精神疾患患者に見出されるST8SIA2/STXの一塩基多型変異体の解析 (2015)
  • Author(s): 羽根正弥, 西村紗希、早川敏之、北島健、佐藤ちひろ
  • Organizer: 第34回日本糖質学会年会
  • Place of Presentation: 東京大学
  • Year and Date: 2015-07-31
• [Remarks] Enzyme assay of polysialyltransferase
  • URL: http://jcggdb.jp/GlycoPOD/protocolShow.action?nodeId=t67