Mechanisms of transcriptional regulation in the germline of primitive chordate species
| Project/Area Number |
15K07071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Tohoku University |
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Principal Investigator |
Kumano Gaku 東北大学, 生命科学研究科, 教授 (80372605)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKAMOTO Ayaki 東北大学, 大学院生命科学研究科, 助教 (40738100)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生殖細胞系列 / 母性局在因子 / 転写制御 / ホヤ / 始原生殖細胞 / 尾索動物 / 比較発生 / PEM / 比較発生学 |
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| Outline of Final Research Achievements |
In animal development germline is segregated from the somatic lineage to maintain its totipotency and ability to be inherited thorough next generations. Transcriptional regulation in the germline is known to play a pivotal role for germline cells to maintain these distinct characteristics. In this study, we used a primitive chordate species, Halocynthia roretzi, and found that three maternally localized factors, Pem, PopK-1 and Zf-1, which are inherited by the Halocynthia germline, regulate germline gene expression during its embryogenesis. Specifically, Pem and Popk-1 suppress somatic gene expression during early embryogenesis while Pem and Zf-1 regulate the timing for the onset of germline gene expression. We also used other closely related primitive chordate species to compare the mechanisms of transcriptional regulation in the germline and found that even among the closely-related species the mechanisms can be different.
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Report
(4 results)
Research Products
(7 results)
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[Presentation] Regulation of germline gene expression in simple chordate embryos.2017
Author(s)
Kumano, G., Miyaoku, K., Zheng, T., Nakamoto, A., Nishino, A.
Organizer
International Research Symposium of Germ Cell Development in vivo and in vitro, Fukuoka
Related Report
Int'l Joint Research / Invited
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