| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Hematopoietic stem cells are generated from the hemogenic endothelium of the dorsal aorta. We developed an efficient method for inducing differentiation of hemogenic endothelial cells from mouse ES cells. We demonstrated that the differentiation potential of hemogenic endothelial cells can be controlled by extracellular signaling molecules. We established a culture system for inducing differentiation of hematopoietic stem cells from hemogenic endothelial cells isolated from mouse embryos. Even by using this culture system, however, we still failed to induce hematopoietic stem cells from ES cell-derived hemogenic endothelial cells. It is thus a future challenge to induce differentiation of genuine hemogenic endothelial cells from ES cells.
|
