| Project/Area Number |
15K07166
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Kyoto University |
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Principal Investigator |
Sato Kei 京都大学, ウイルス・再生医科学研究所, 講師 (10593684)
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| Co-Investigator(Renkei-kenkyūsha) |
Koyanagi Yoshio 京都大学・ウイルス, 再生医科学研究所, 教授 (80215417)
Iwasa You 九州大学, 理学研究院, 教授 (70176535)
Iwami Shingo 九州大学, 理学研究院, 准教授 (90518119)
Ren FengRong 東京医科歯科大学, 難治疾患研究所, 特任准教授 (60280989)
Nakagawa So 東海大学, 医学部, 講師 (70510014)
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| Research Collaborator |
Dong Sung An カリフォルニア大学ロサンゼルス校, 教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | システムウイルス学 / HIV-1 / チンパンジー / ヒト化マウス / 適応進化 / HIV / SIV / 進化ウイルス学 / エイズ |
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| Outline of Final Research Achievements |
HIV-1, the causative agent of AIDS, is originated from SIVcpz, the chimpanzee precursor of the human virus, approximately 100 years ago. This indicates that HIV-1 has emerged through the cross-species transmission of SIVcpz from chimpanzees to humans. However, it remains unclear how SIVcpz has evolved into pandemic HIV-1 in humans. To address this question, we used three SIVcpz (MB897, EK505, and MT145), four pandemic HIV-1 (NL4-3, NLCSFV3, JRCSF and AD8) and 2 non-pandemic HIV-1 (YBF30 and DJO0131) strains and humanized mouse model. This is the first experimental investigation to use an animal model to demonstrate a gain-of-function evolution of SIVcpz into pandemic HIV-1.
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