| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Streptomyces hormones induce the production of secondary metabolites by binding to the cognate receptors in actinomycetes. In this study, I aimed to awaken cryptic useful secondary metabolites through the manipulation of signaling cascades governed by Streptomyces hormones, and to identify actinomycetes strains in which butenolide-type Streptomyces hormones control secondary metabolism. I demonstrated that gene disruption of Streptomyces-hormone receptor activates the production of phthoxazolin A in Streptomyces avermitilis, and that phthoxazolin A biosynthetic genes are encoded on an extra genomic region that is not found in the public database. Furthermore, identification of butenolide-type Streptomyces hormone-like compounds from Streptomyces albus J1074 led to structure-activity relationship for butenolide-type Streptomyces hormones, as well as chemical communication between different streptomycetes via Streptomyces hormones.
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