Mechanism of link between energy homeostasis and onset of differentiation in Streptomyces
| Project/Area Number |
15K07370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Nihon University |
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Principal Investigator |
UEDA Kenji 日本大学, 生物資源科学部, 教授 (00277401)
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| Co-Investigator(Kenkyū-buntansha) |
高野 英晃 日本大学, 生物資源科学部, 准教授 (50385994)
西山 辰也 日本大学, 生物資源科学部, 助手 (10759541)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Streptomyces / energy metabolism / cell differentiation / secondary metabolism / homeostasis / transcription / regulation / antibiotics / エネルギー代謝 / 遺伝制御 / 恒常性 / 二次代謝 / 形態分化 |
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| Outline of Final Research Achievements |
Antibiotic production and morphological differentiation in Streptomyces is stimulated by a high concentration of copper ion. Here, we revealed that the stimulation is based on the energy homeostatic mechanisms including the following systems: (1) negative regulation of ATP synthase operon by a transcriptional regulator Rex, and (2) positive regulation of succinate dehydrogenase operon by a specific LysR-type transcriptional regulator. Thus controlled intracellular energetic state may serve as a signal for the onset of development.
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Report
(4 results)
Research Products
(6 results)
