| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Diversity-oriented synthesis (DOS) aims to generate chemical librarys, which have structural diversity in an efficient manner. Diversity-oriented synthesis is used as a tool for the discovery of biologically and functionally active small molecules. However, DOS requires novel strategies that differ from the majority of traditional chemical syntheses. In this study, we focus on unified and common intermediate strategies for the synthesis lactams and naphthoquinone dimers. Efficient syntheses of lactams and naphthoquinone dimers were developed. Severel natural products and their structurally related analogues were prepared based on the strategies. Functional and biological evaluation of synthetic compounds revealed novel candidate compounds.
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