Muscle type-specific inhibition of atrophy using the differential response of muscle types to the protein synthetic stimulus of leucine
| Project/Area Number |
15K07423
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Utsunomiya University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ロイシン / 骨格筋 / 筋肉タイプ / タンパク質合成 / mTOR / 筋萎縮 / デキサメタゾン / Sestrin2 |
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| Outline of Final Research Achievements |
The findings from this study suggest that the protein synthetic response of rat skeletal muscle to leucine stimulation is different between muscle fiber types. It appears that skeletal muscles rich in slow fibers are more sensitive to leucine stimulation, but the magnitude of the acceleration of protein synthesis in these muscles is lower than that in muscles rich in fast fibers. We also investigated the inhibitory effects of leucine on muscle atrophy in a rat model of dexamethasone-induced skeletal muscle atrophy. Unfortunately, no significant inhibitory effects of leucine were observed in this model.
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Report
(4 results)
Research Products
(5 results)
