Anti-cancer effect of nitro-fatty acid
| Project/Area Number |
15K07434
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Research Collaborator |
SUGAMOTO kazuhiro 宮崎大学, 工学部, 准教授 (10274771)
YAMASAKI masao 宮崎大学, 農学部, 教授 (80381060)
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | ニトロオレイン酸 / 抗がん作用 / 細胞増殖 / 細胞遊走 / 親電子性物質 / がん細胞 / 増殖抑制 / ニトロ化脂肪酸 / 細胞増殖抑制 / 細胞死誘導 |
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| Outline of Final Research Achievements |
The effects of chemically synthesized 9-nitrooleate on cancer cell growth and migration were evaluated by using human bladder cancer cell line T24. 9-Nitrooleate inhibited cell growth in a concentration dependent manner at μM level and induced cell death at concentrations higher than 50 μM. On the other hand, 9-nitrooleate promoted cancer cell migration at concentrations lower than 10μM. Sulforaphane, a typical anti-cancer isothiocyanate, showed almost the same effect as 9-nitrooleate. It is suggested that further studies are necessary to clarify the effects of electrophiles such as nitro-fatty acids and isothiocyanates on cancer cells.
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| Academic Significance and Societal Importance of the Research Achievements |
がんの発生や転移には慢性的な炎症が関与している。不飽和脂肪酸と酸化窒素化合物の反応で生成するニトロ化脂肪酸が抗炎症作用を示すことが報告されており、その作用に親電子性が関与していることが示唆されている。親電子性物質には抗炎症作用のみならず抗がん作用を示すものが多いが、ニトロ化脂肪酸のがん細胞に対する作用に関する研究は行われていなかった。本研究では、9-ニトロオレイン酸が、がん細胞の増殖を抑制するが、条件によっては、がんの転移に関係する細胞の遊走を促進することを明らかにすることにより、ニトロ化脂肪酸を含めた親電子性物質のがん細胞に対する作用については、さらに詳細な検討が必要であることを提示した。
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] Blueberry Leaf Polyphenols Prevent Body Fat Accumulation in Mice Fed High-fat, High-sucrose Diet2019
Author(s)
K. Fujii, Y. Ota, K. Nishiyama, H. Kunitake, Y. Yamasaki, H. Tari, K. Araki, T. Arakawa, M. Yamasaki
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Journal Title
Journal of Oleo Science
Volume: 68
Issue: 5
Pages: 471-479
DOI
NAID
ISSN
1345-8957, 1347-3352
Related Report
Peer Reviewed / Open Access
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[Journal Article] A single dose of blueberry leaf extract suppresses serum ethanol levels after oral ethanol administration in rats2016
Author(s)
K. Yamasaki, H. Nagatomo, Y. Kawamura, K. Sugamoto, T. Kai, K. Kamenaga, M. Takeshita, Y. Kikuchi, Y. Matsuura, C. Yukizaki, K. Nishiyama, M. Yamasaki
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Journal Title
Journal of Scientific Research
Volume: 140
Pages: 352-365
Related Report
Peer Reviewed
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[Journal Article] Suppressing effect of cordycepin on the lipopolysaccharide- induced nitric oxide production in RAW 264.7 cells.2015
Author(s)
K. Imamura, M. Asai, T. Matsumoto, Y.Yamasaki, I. Kamei, T. Hattori, M. Kishimoto, S. Niisaka, M. Kubo, K. Nishiyama, M. Yamasaki
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Journal Title
Biosci Biotechnol Biochem
Volume: in press
Issue: 6
Pages: 1021-1025
DOI
Related Report
Peer Reviewed
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[Journal Article] Blueberry (<i>Vaccinium virgatum</i> Aiton) Leaf Infusion Ameliorates Insulin Resistance in Mice Fed a High-fat, High-sucrose Diet2015
Author(s)
Yamasaki M., Matsuyama Y., Hayasegawa R., Hamada K., Nishiyama K., Kai T., Kamenaga K., Arakawa T., Tari H., Shimizu Y., Matsuura Y., Yukizaki C.
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Journal Title
Food Science and Technology Research
Volume: 21
Issue: 6
Pages: 827-833
DOI
NAID
ISSN
1344-6606, 1881-3984
Related Report
Peer Reviewed
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