| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, by using a reverse genetics system of the live rabies vaccine strain ERA, we aimed to improve safety and immunogenicity of live rabies vaccine. By introducing a novel attenuating mutation into the viral genome, we have successfully established a live vaccine candidate that is highly and stably attenuated. Meanwhile, although we have generated a candidate with codon-optimized G gene, we were not able to observe increased expression level of G protein and enhanced immunogenicity. The findings above will be important fundamental information for development of live rabies vaccines by using a reverse genetics approach in the future.
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