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Experimental demonstration of the involvement of immune-mediated mechanism(s) for rapid manifestation of Kudoa food poisioning after consumption of raw fish

Research Project

Project/Area Number 15K07722
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionYamaguchi University

Principal Investigator

Sato Hiroshi  山口大学, 共同獣医学部, 教授 (90211945)

Co-Investigator(Kenkyū-buntansha) 柳田 哲矢  山口大学, 共同獣医学部, 准教授 (40431837)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsKudoa food poisoning / クドア食中毒 / marine fish / 海産魚 / Myxozoa / ミクソゾア / Myxosporea / 粘液胞子虫 / Kudos / 生物多様性 / 市販海産魚 / Kudoa septempunctata / Kudoa parathyrsites / Kudoa pleurogrammi / Kudoa shiomitsui / Kudoa iwatai / Kudoa trachuri
Outline of Final Research Achievements

'Kudoa food poisoning' was newly recognized in 2011 as a human disease manifested by diarrhea and vomiting after consumption of fresh marine fish with Kudoa spores. Since pre-symptomatic time is 4 to 19 (average 5) hours after raw fish consumption, not only mechanical destruction of the epithelium of gastrointestinal mucosa, but also immune-mediated deterioration of mucosal lesion(s) might be suspected. To carry out laboratory demonstration using model systems, abundant numbers of Kudoa spores should be prepared. To find such sources of spores, commercially available marine fish were checked widely, and at last 12 known species and five new species were isolated from marine fish around Japan. It is finally concluded that bluespine unicornfish with Kudoa thalassomi, Carolines parrotfish, African coris, and Pasterl ringwrasse with Kudoa igami, all of which were fished in the sea around Miyako Island, Okinawa, could provide sufficient number of Kudoa spores for laboratory uses.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (23 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (5 results) Journal Article (11 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 10 results,  Open Access: 2 results,  Acknowledgement Compliant: 5 results) Presentation (7 results)

  • [Int'l Joint Research] 広東海洋大学/中国科学アカデミー水棲生物研究所(中国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Airlangga University(インドネシア)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Agriculture and Forestry University(ネパール)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] 内モンゴル農業大学/広東海洋大学(中国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] 済州大学(韓国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Morphological and molecular genetic characterization of Kudoa konishiae n. sp. (Myxosporea: Multivalvulida) in the muscle of Japanese Spanish mackerel (Scomberomorus niphonius)2018

    • Author(s)
      Sakai Haruya、Kato Eigo、Sakaguchi Seiho、Setsuda Aogu、Sato Hiroshi
    • Journal Title

      Parasitology Research

      Volume: 117 Issue: 3 Pages: 893-904

    • DOI

      10.1007/s00436-018-5770-5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological and genetic characterization of Kudoa whippsi (Myxosporea: Multivalvulida) from Cheilodactylus zonatus in the western Pacific Ocean off Japan, and two new Kudoa spp. (K. akihitoi n. sp. and K. empressmichikoae n. sp.) from Acanthogobius hasta in the Sea of Ariake, Japan2017

    • Author(s)
      Kasai Akihiro、Setsuda Aogu、Sato Hiroshi
    • Journal Title

      Parasitology Research

      Volume: 116 Issue: 2 Pages: 647-659

    • DOI

      10.1007/s00436-016-5329-2

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Incidence of three Kudoa spp., K. neothunni, K. hexapunctata, and K. thunni (Myxosporea: Multivalvulida), in Thunnus tunas distributed in the western Pacific Ocean2017

    • Author(s)
      Kasai Akihiro、Tsuduki Hideaki、Jimenez Lea Angsinco、Li Ying-Chun、Tanaka Shuhei、Sato Hiroshi
    • Journal Title

      Parasitology Research

      Volume: 116 Issue: 4 Pages: 1137-1150

    • DOI

      10.1007/s00436-016-5369-7

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Four Myxobolus spp. (Myxosporea: Bivalvulida) from the gill lamellae of common carp (Cyprinus carpio) and Japanese silver crucian carp (Carassius langsdorfii) in the western part of Japan, with the description of three new species (M. tanakai n. sp., M. paratoyamai n. sp., and M. ginbuna n. sp.)2017

    • Author(s)
      Kato Eigo、Kasai Akihiro、Tomochi Hisayuki、Li Ying-Chun、Sato Hiroshi
    • Journal Title

      Parasitology Research

      Volume: 116 Issue: 9 Pages: 2427-2441

    • DOI

      10.1007/s00436-017-5545-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Production of a novel monoclonal antibody applicable for an immunochromatographic assay for Kudoa septempunctata spores contaminating the raw olive flounder (Paralichthys olivaceus).2017

    • Author(s)
      Jinnai M, Kawai T, Harada T, Nishiyama Y, Yokoyama H, Shirakashi S, Sato H, Sakata J, Kumeda Y, Fukuda Y, Ogata K, Kawatsu K.
    • Journal Title

      Int. J. Food Microbiol.

      Volume: 259 Pages: 59-67

    • DOI

      10.1016/j.ijfoodmicro.2017.08.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New host records of monacanthid fish for three Kudoa spp. (K. septempunctata, K. thyrsites, and K. shiomitsui) prevalent in the olive flounder (Paralichthys olivaceus), with the description of K. parathyrsites n. sp. from a black scraper (Thamnaconus modestus)2016

    • Author(s)
      Kasai A, Li YC, Mafie E, Sato H
    • Journal Title

      Parasitol Res

      Volume: 印刷中 Issue: 7 Pages: 2741-2755

    • DOI

      10.1007/s00436-016-5023-4

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Enteromyxum leei (Myxosporea: Bivalvulida) as the cause of myxosporean emaciation disease of farmed olive flounders (Paralichthys olivaceus) and a turbot (Scophthalmus maximus) on Jeju Island, Korea2016

    • Author(s)
      Sekiya M, Setsuda A, Sato H, Song K, Han J-K, Kim G-J, Yeo IK
    • Journal Title

      Parasitol Res

      Volume: 115 Issue: 11 Pages: 4229-4237

    • DOI

      10.1007/s00436-016-5200-5

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 日本ならびにその近海で記録されたクドア属粘液胞子虫(1930~2016)2016

    • Author(s)
      佐藤 宏、笠井亨浩
    • Journal Title

      獣医寄生虫誌

      Volume: 15 Pages: 111-138

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] Morphological and molecular genetic characterization of two Kudoa spp., K. musculoliquefaciens, and K. pleurogrammi n. sp. (Myxosporea: Multivalvulida), causing myoliquefaction of commercial marine fish2016

    • Author(s)
      Kasai A, Li YC, Mafie E, Sato H
    • Journal Title

      Parasitol Res

      Volume: 115 Issue: 5 Pages: 1883-1892

    • DOI

      10.1007/s00436-016-4928-2

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] <i>Henneguya doneci</i> (Myxosporea: Bivalvulida) in the gill filaments of Prussian carp <i>Carassius gibelio</i> (Bloch) from the upper Yellow River running through Inner Mongolia, China2015

    • Author(s)
      Li YC, Zhang Y, Siriguleng, Sato H
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 8 Pages: 1001-1005

    • DOI

      10.1292/jvms.14-0666

    • NAID

      130005096707

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic characterization of Kudoa iwatai and Kudoa trachuri in commercial marine fish( Platycephalus sp. and Trachurus japonicus) for human consumption2015

    • Author(s)
      Kasai A, Li YC, Setsuda A, Mafie E, Sato H
    • Journal Title

      Jpn J Vet Parasitol

      Volume: 14 Pages: 22-30

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 山口市内のウナギから検出された双殻目粘液胞子虫5種.2017

    • Author(s)
      加藤英悟、坂口星帆、笠井亨浩、説田 景、柳田哲矢、佐藤宏
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 山口県産ならびに鹿児島県産サワラから検出した未知の多殻目Kudoa種について.2017

    • Author(s)
      笠井亨浩、友知久幸、坂井晴哉、説田景、柳田哲矢、佐藤宏
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高知県産イトヨリダイから検出した未知の多殻目Unicapsula種について.2017

    • Author(s)
      友知久幸、笠井亨浩、関谷麻里子、説田 景、柳田哲矢、佐藤宏
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 日本近海魚から新たに得た7-9殻片/極嚢の胞子を特徴とするクドア3種:Kudoa yasunagai, Kudoa thalassomi, Kudao igami.2017

    • Author(s)
      坂井晴哉、説田景、柳田哲矢、佐藤宏
    • Organizer
      第87回日本寄生虫学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 日本近海の天然魚タカノハダイとハゼクチからのクドア粘液胞子虫3種の検出2016

    • Author(s)
      笠井亨浩、E. Mafie、F H Rupa、説田 景、佐藤 宏
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源学部(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Myxosporean emaciation disease caused by Enteromyxum lee in farmed olive flounders (Paralichthys olivaceous) and a turbot (Scophthalmus maximus) on Jeju Island, Korea2016

    • Author(s)
      Sekiya M, Setsuda A, Sato H, Song K, Han J-K, Kim G-J, Yeo IK
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学生物資源学部(神奈川県藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 日本近海産のカワハギ科魚類におけるクドア感染例―ウマヅラハギのKudoa septempunctata寄生とカワハギのKudoa shiomitsui寄生―2015

    • Author(s)
      笠井亨浩、坂口星帆、加藤英吾、説田 景、Mafie Eliakunda、佐藤 宏
    • Organizer
      第71回日本寄生虫学会西日本支部大会
    • Place of Presentation
      奈良女子大学(奈良県奈良市)
    • Year and Date
      2015-10-25
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2022-02-07  

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