| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Stress disrupts biological rhythm, and causes various diseases. The aim of this study was to analyze the effect of stress on biological rhythm from the viewpoint of biomarkers in saliva and to find stress markers that can be used in various animal species. Studies using mouse and monkey revealed that the stress decreases immunoglobulin A (IgA) in saliva, and eliminates the circadian rhythm of salivary IgA. Salivary IgA may be a biomarker that can simultaneously monitor biological rhythm and stress response.
|
