• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of interrelationships of stress, biological clock, and health conditions focusing on salivary biomarkers as indicator

Research Project

Project/Area Number 15K07740
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionThe University of Tokyo

Principal Investigator

Yokota Shin-Ichi  東京大学, 医科学研究所, 助教 (10743239)

Co-Investigator(Renkei-kenkyūsha) SHIBATA Shigenobu  早稲田大学, 理工学術院, 教授 (10162629)
MATSUDA Hiroshi  東京農工大学, 農学研究科, 教授 (80145820)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsバイオマーカー / ストレス / サーカディアンリズム / 霊長類 / 動物種差
Outline of Final Research Achievements

Stress disrupts biological rhythm, and causes various diseases. The aim of this study was to analyze the effect of stress on biological rhythm from the viewpoint of biomarkers in saliva and to find stress markers that can be used in various animal species. Studies using mouse and monkey revealed that the stress decreases immunoglobulin A (IgA) in saliva, and eliminates the circadian rhythm of salivary IgA. Salivary IgA may be a biomarker that can simultaneously monitor biological rhythm and stress response.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Leucine restores murine hepatic triglyceride accumulation induced by a low-protein diet by suppressing autophagy and excessive endoplasmic reticulum stress.2016

    • Author(s)
      Yokota S, Ando M, Aoyama S, Nakamura K, Shibata S.
    • Journal Title

      Amino Acids.

      Volume: 48 Issue: 4 Pages: 1013-1021

    • DOI

      10.1007/s00726-015-2149-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi