Study on vaccine using food allergen-producing lactic acid bacterium in food allergy
Project/Area Number |
15K07756
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Veterinary medical science
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Research Institution | Azabu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
五十君 静信 国立医薬品食品衛生研究所, 食品衛生管理部, 客員研究員 (70212743)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 食物アレルギー / オボアルブミン / 乳酸菌 / イヌ / マウス / 卵 / アレルゲン |
Outline of Final Research Achievements |
Ovalbumin (OVA)-producing lactic acid bacteria (LB) were orally administrated to mice, followed by an intraperitoneal injection of OVA and alum. There were no differences in the levels of OVA-specific IgE between the group that received OVA-producing LB and the control groups, suggesting that the OVA-producing ability of these LB was low. Next, a mixture of OVA and LB was administered orally to mice. We found that the administration of more than 10 μg of OVA suppresses the levels of OVA-specific IgE. Mixtures of OVA and LB may therefore be used in immunotherapy for egg allergies. We then measured the levels of IgE specific to egg allergens in 82 dogs with food allergies. Approximately 10% of these dogs produced IgE specific to crude white egg. Furthermore, 75% of dogs with IgE specific to crude white egg also produced OVA-specific IgE. This suggests that a mixture of egg allergens and LB could be used in immunotherapy for food allergy in dogs.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Recovery of mycobacteriophages from archival stocks stored for approximately 50 years in Japan.2018
Author(s)
Ujihara T, Uchiyama J, Nasukawa T, Ando H, Murakami H, Ohara N, Ogawa M, Yamazaki T, Daibata M, Sakaguchi M, Matsuzaki S.
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Journal Title
Archives of Virology
Volume: in press
Issue: 7
Pages: 1-5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Piperacillin and ceftazidime produce the strongest synergistic phage-antibiotic effect in Pseudomonas aeruginosa.2018
Author(s)
Uchiyama J, Shigehisa R, Nasukawa T, Mizukami K, Takemura-Uchiyama I, Ujihara T, Murakami H, Imanishi I, Nishifuji K, Sakaguchi M, Matsuzaki S.
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Journal Title
Archives of Virology
Volume: in press
Issue: 7
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Identification of the PLA2G6 c.1579G>A missense mutation in Papillon dog neuroaxonal dystrophy using whole exome sequencing analysis.2017
Author(s)
Tsuboi M, Watanabe M, Nibe K, Yoshimi N, Kato A, Sakaguchi M, Yamato O, Tanaka M, Kuwamura M, Kushida K, Ishikura T, Harada T, Chambers JK, Sugano S, Uchida K, Nakayama H.
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Journal Title
PLoS One
Volume: 12
Issue: 1
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Adsorption of Staphylococcus viruses S13´ and S24-1 on Staphylococcus aureus strains with different glycosidic linkage patterns of wall teichoic acids.2017
Author(s)
Uchiyama, J., Taniguchi, M., Kurokawa, K., Takemura-Uchiyama, I., Ujihara, T., Shimakura, H., Sakaguchi, Y., Murakami, H., Sakaguchi, M., Matsuzaki, S.
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Journal Title
J. Gen. Virol.
Volume: 98(8)
Issue: 8
Pages: 2171-2180
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characterization of Pseudomonas aeruginosa phage KPP21 belonging to family Podoviridae genus N4-like viruses isolated in Japan2016
Author(s)
Shigehisa, R., Uchiyama, J., Kato S, Takemura-Uchiyama, I, Yamaguchi, K., Miyata, R., Ujihara, T., Sakaguchi, Y., Okamoto, N., Shimakura, H., Daibata, M., Sakaguchi, M., and Matsuzaki, S.
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Journal Title
Microbiology and Immunology
Volume: 60
Issue: 1
Pages: 64-67
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Cross-reactivity between major IgE core epitopes on Cry j 2 allergen of Japanese cedar pollen and relevant sequences on Cha o 2 allergen of Japanese cypress pollen2016
Author(s)
Miyaji, K., Okamoto, N., Saito, S., Yasueda, H., Takase, Y., Shimakura, H., Saito, S., and Sakaguchi, M.
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Journal Title
Allergology International
Volume: 65
Issue: 3
Pages: 286-292
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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[Journal Article] Analyses of Short-Term Antagonistic Evolution of Pseudomonas aeruginosa Strain PAO1 and Phage KPP22 (Myoviridae Family, PB1-Like Virus Genus).2016
Author(s)
Uchiyama J, Suzuki M, Nishifuji K, Kato S, Miyata R, Nasukawa T, Yamaguchi K, Takemura-Uchiyama I, Ujihara T, Shimakura H, Murakami H, Okamoto N, Sakaguchi Y, Shibayama K, Sakaguchi M, Matsuzaki S.
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Journal Title
Appl Environ Microbiol
Volume: 82
Issue: 15
Pages: 4482-4491
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Screening of KHP30-like prophages among Japanese Helicobacter pylori strains, and genetic analysis of a defective KHP30-like prophage sequence integrated in the genome of the H. pylori strain NY40.2016
Author(s)
Uchiyama J, Takemura-Uchiyama I, Kato S, Takeuchi H, Sakaguchi Y, Ujihara T, Daibata M, Shimakura H, Okamoto N, Sakaguchi M, Matsuzaki S.
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Journal Title
FEMS Microbiol Lett.
Volume: 363
Issue: 16
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] IgE reactivity to hen’s egg white allergens in dogs with cutaneous adverse food reactions.2016
Author(s)
Shimakura, H., Saito, T., Uchiyama, J., Miyaji, K., Fujimura, M., Masuda, K., Okamoto, N., DeBoer, D.J., Sakaguchi, M.
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Journal Title
Veterinary Immunology and Immunopathology
Volume: 177
Pages: 52-57
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Inefficient viral replication of bovine leukemia virus induced by spontaneous deletion mutation on G4 gene.2016
Author(s)
Murakami, H., Uchiyama, J., Nikaido, S., Sato, R., Sakaguchi, M., Tsukamoto, K.
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Journal Title
Journal of General Virology
Volume: 97
Issue: 10
Pages: 2753-2762
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nationwide distribution of bovine influenza D virus infection in Japan.2016
Author(s)
Horimoto T, Hiono T, Mekata H, Odagiri T, Lei Z, Kobayashi T, Norimine J, Inoshima Y, Hikono H, Murakami K, Sato R, Murakami H, Sakaguchi M, Ishii K, Ando T, Otomaru K, Ozawa M, Sakoda Y, Murakami S.
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Journal Title
PloSOne
Volume: 11 (9)
Issue: 9
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Cross-reactivity between major IgE core epitopes on Cry j 2 allergen of Japanese cedar pollen and relevant sequences on Cha o 2 allergen of Japanese cypress pollen2016
Author(s)
Miyaji, K., Okamoto, N., Saito, S., Yasueda, H., Takase, Y., Shimakura, H., Saito, S., and Sakaguchi, M.
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Journal Title
Allergology International
Volume: in press
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Analysis of KHP30-like prophage in the genome of Helicobacter 4 pylori strain NY40.2016
Author(s)
Uchiyama, J , Takemura-Uchiyama, I., Kato, S., Takeuchi, H., Sakaguchi, Y., Ujihara, T., Daibata, M., Shimakura, H., Okamoto, N., Sakaguchi, M., Matsuzaki, S.
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Journal Title
FEMS Microbiology Letters
Volume: in press
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Cats as a potential source of emerging influenza virus infections2015
Author(s)
Horimoto. T., Gen, F., Murakami, S., Iwatsuki-Horimoto, K., Kato, K., Hisasue, M., Sakaguchi, M., Nidom, C.A., and Kawaoka, Y
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Journal Title
Virologica Sinica
Volume: 30
Issue: 3
Pages: 221-223
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Serological survey reveals the wide distribution of bovine influenza D virus infection in Japan2016
Author(s)
Taisuke Horimoto, Tomoha Odagiri, Zhihao Lei, Tomoya Kobayashi, Maiko Endo, Akiko Uema, Hirohisa Mekata, Junzo Norimine, Kenji Murakami, Hironobu Murakami, Masahiro Sakaguchi, Kazunori Ishii, Yasuo Inoshima, Makoto Ozawa, Takahiro Hiono, Yoshihiro Sakoda, Benjamin Hause, Shin Murakami
Organizer
第64回日本ウイルス学会
Place of Presentation
札幌
Year and Date
2016-10-23
Related Report
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