Clarification of the secretory complement system in alimentary tract
| Project/Area Number |
15K07766
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
河野 潤一 神戸大学, 農学研究科, 教授 (40127361)
万谷 洋平 神戸大学, 農学研究科, 特命助教 (30724984)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生体防御機構 / 消化器系 / 呼吸器系 / 補体 / 自然免疫 / 常在細菌 / Toll-like receptor / 免疫組織化学 / 外分泌 / 補体受容体 / 小腸 / 呼吸器 / ラット / 腸管分泌 / 消化管 / 補体分泌 / 補体経路 |
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| Outline of Final Research Achievements |
The research achievements on the secretory complement and complement receptors in alimentary tract and respiratory tract of rats are as follows: the clarification of the distribution of secretory cells of C3 and C4 throughout both rat alimentary tracts and respiratory tract, the clarification of the resorption of the luminal C3 and C4 by microvillous epithelial cells with late apoptosis stage and the direct transportation of C3 and C4 into the subepithelial blood capillaries, the clarification of no production of C3 and C4 into intestinal lumen from the liver which is the main production site of C3 and C4 in the body, the clarification of the distribution of some elements of complement and a part of complement receptors throughout both rat alimentary tracts and respiratory tract.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Immunohistochemical study on the distribution of β-defensin 1 and β-defensin 2 throughout the respiratory tract of healthy rats2018
Author(s)
Masuda N, Mantani Y, Yuasa H, Yoshitomi C, Arai M, Nishida M, Qi W-M, Kawano J, Yokoyama T, Hoshi N, Kitagawa H
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Journal Title
Journal of Veterinary Medical Science
Volume: 80
Issue: 3
Pages: 395-404
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Immunohistochemical study on the secretory host defense system with lysozyme and secretory phospholipase A2 throughout rat respiratory tract2018
Author(s)
Masuda N, Mantani Y, Yuasa H, Yoshitomi C, Nishida M, Arai M, Kawano J, Yokoyama T, Hoshi N, Kitagawa H
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Journal Title
Journal of Veterinary Medical Science
Volume: 80
Issue: 2
Pages: 323-332
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access
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[Journal Article] Immunohistochemical and histoplanimetrical study on the endothelial receptor involved in transportation of minute chylomicrons into subepithelial portal blood in intestinal villi of the rat jejunum2015
Author(s)
Ei-ichirou TAKAHARA, Hideto YUASA, Miho NISHIDA, Youhei MANTANI, Udayanga KANKANAM GAMAGE SANATH, Wang-Mei QI, Takashi TAKEUCHI, Toshifumi YOKOYAMA, Nobuhiko HOSHI, Hiroshi KITAGAWA
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Journal Title
Journal of Veterinary Medical Science
Volume: 77
Issue: 4
Pages: 387-393
DOI
NAID
ISSN
0916-7250, 1347-7439
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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