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Clarification of the secretory complement system in alimentary tract

Research Project

Project/Area Number 15K07766
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrative animal science
Research InstitutionKobe University

Principal Investigator

KITAGAWA Hiroshi  神戸大学, 農学研究科, 教授 (40125307)

Co-Investigator(Kenkyū-buntansha) 河野 潤一  神戸大学, 農学研究科, 教授 (40127361)
万谷 洋平  神戸大学, 農学研究科, 特命助教 (30724984)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords生体防御機構 / 消化器系 / 呼吸器系 / 補体 / 自然免疫 / 常在細菌 / Toll-like receptor / 免疫組織化学 / 外分泌 / 補体受容体 / 小腸 / 呼吸器 / ラット / 腸管分泌 / 消化管 / 補体分泌 / 補体経路
Outline of Final Research Achievements

The research achievements on the secretory complement and complement receptors in alimentary tract and respiratory tract of rats are as follows: the clarification of the distribution of secretory cells of C3 and C4 throughout both rat alimentary tracts and respiratory tract, the clarification of the resorption of the luminal C3 and C4 by microvillous epithelial cells with late apoptosis stage and the direct transportation of C3 and C4 into the subepithelial blood capillaries, the clarification of no production of C3 and C4 into intestinal lumen from the liver which is the main production site of C3 and C4 in the body, the clarification of the distribution of some elements of complement and a part of complement receptors throughout both rat alimentary tracts and respiratory tract.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (23 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (14 results) (of which Int'l Joint Research: 1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] 内蒙古農業大学(中国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Ultrastructural and Immunohistochemical Study on the Lamina Propria Cells Beneath Paneth Cells in the Rat Ileum2018

    • Author(s)
      Mantani Youhei、Nishida Miho、Yamamoto Kyouji、Miyamoto Kazuki、Yuasa Hideto、Masuda Natsumi、Omotehara Takuya、Tsuruta Hiroki、Yokoyama Toshifumi、Hoshi Nobuhiko、Kitagawa Hiroshi
    • Journal Title

      The Anatomical Record

      Volume: 印刷中 Issue: 6 Pages: 1074-1085

    • DOI

      10.1002/ar.23778

    • NAID

      120006708265

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistochemical study on the distribution of β-defensin 1 and β-defensin 2 throughout the respiratory tract of healthy rats2018

    • Author(s)
      Masuda N, Mantani Y, Yuasa H, Yoshitomi C, Arai M, Nishida M, Qi W-M, Kawano J, Yokoyama T, Hoshi N, Kitagawa H
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 3 Pages: 395-404

    • DOI

      10.1292/jvms.17-0686

    • NAID

      130006539130

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunohistochemical study on the secretory host defense system with lysozyme and secretory phospholipase A2 throughout rat respiratory tract2018

    • Author(s)
      Masuda N, Mantani Y, Yuasa H, Yoshitomi C, Nishida M, Arai M, Kawano J, Yokoyama T, Hoshi N, Kitagawa H
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 80 Issue: 2 Pages: 323-332

    • DOI

      10.1292/jvms.17-0503

    • NAID

      130006410768

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanism of M-cell differentiation accelerated by proliferation of indigenous bacteria in rat Peyer’s patches2017

    • Author(s)
      YUASA Hideto、MANTANI Youhei、MASUDA Natsumi、NISHIDA Miho、ARAI Masaya、YOKOYAMA Toshifumi、TSURUTA Hiroki、KAWANO Junichi、HOSHI Nobuhiko、KITAGAWA Hiroshi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 79 Issue: 11 Pages: 1826-1835

    • DOI

      10.1292/jvms.17-0470

    • NAID

      130006206573

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential expression of Toll-like receptor-2, -4 and -9 in follicle-associated epithelium from epithelia of both follicle-associated intestinal villi and ordinary intestinal villi in rat Peyer’s patches2016

    • Author(s)
      YUASA Hideto, MANTANI Youhei, MASUDA Natsumi, NISHIDA Miho, KAWANO Junichi, YOKOYAMA Toshifumi, HOSHI Nobuhiko, KITAGAWA Hiroshi
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 78 Issue: 12 Pages: 1797-1804

    • DOI

      10.1292/jvms.16-0349

    • NAID

      130005286396

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ultrastructural study on the morphological changes in indigenous bacteria of mucous layer and chyme throughout the rat intestine. The Journal of Veterinary Medical Science2015

    • Author(s)
      Youhei MANTANI, Eri ITO, Miho NISHIDA, Hideto YUASA, Natsumi MASUDA, Wang-Mei QI, Junichi KAWANO, Toshifumi YOKOYAMA, Nobuhiko HOSHI, Hiroshi KITAGAWA
    • Journal Title

      The Journal of Veterinary Medical Science

      Volume: 77 Pages: 1121-1128

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Immunohistochemical and histoplanimetrical study on the endothelial receptor involved in transportation of minute chylomicrons into subepithelial portal blood in intestinal villi of the rat jejunum2015

    • Author(s)
      Ei-ichirou TAKAHARA, Hideto YUASA, Miho NISHIDA, Youhei MANTANI, Udayanga KANKANAM GAMAGE SANATH, Wang-Mei QI, Takashi TAKEUCHI, Toshifumi YOKOYAMA, Nobuhiko HOSHI, Hiroshi KITAGAWA
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 4 Pages: 387-393

    • DOI

      10.1292/jvms.14-0432

    • NAID

      130005067015

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] ラット大腸の上皮直下における間質細胞の部位差に関する免疫組織化学的研究2017

    • Author(s)
      田村彩貴、万谷洋平、西田美穂、湯浅秀人、増田なつみ、横山俊史、星 信彦、北川 浩
    • Organizer
      第93回日本解剖学会近畿支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生理的条件下のラット呼吸器系粘膜における補体成分C3と補体受容体C3aRおよびCD11bの局在に関する免疫組織化学的研究2017

    • Author(s)
      吉冨千晶、増田なつみ、湯浅秀人、西田美穂、万谷洋平、河野潤一、横山俊史、星 信彦、北川 浩
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Serial block face-走査型電子顕微鏡を用いたラット回腸腸陰窩周囲の間質細胞に関する3次元超微形態学的解析2017

    • Author(s)
      万谷洋平、春田知洋、西田美穂、湯浅秀人、増田なつみ、横山俊史、星 信彦、北川 浩
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラットパイエル板におけるlysozyme陽性細胞を介する生体防御機構に関する免疫組織化学的研究2017

    • Author(s)
      宮本和樹、万谷洋平、湯浅秀人、西田美穂、増田なつみ、横山俊史、星 信彦、北川 浩
    • Organizer
      第160回日本獣医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット回腸粘膜における各種間質細胞の局在2016

    • Author(s)
      万谷洋平,宮本和樹,西田美穂,湯浅秀人,増田なつみ,横山俊史,星 信彦,北川 浩
    • Organizer
      第92回日本解剖学会近畿支部学術集会
    • Place of Presentation
      近畿大学(大阪府・狭山市)
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
  • [Presentation] ラットパイエル板における濾胞被蓋上皮のアポトーシスとRANK/RANKLの発現との関係2016

    • Author(s)
      湯浅秀人,万谷洋平,増田なつみ,西田美穂,河野潤一,横山俊史,星 信彦,北川 浩
    • Organizer
      第92回日本解剖学会近畿支部学術集会
    • Place of Presentation
      近畿大学(大阪府・狭山市)
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット呼吸器系粘膜を覆う粘液層における β-defensin 1 および β-defensin 2 の存在および分泌源の同定2016

    • Author(s)
      増田なつみ,万谷洋平,西田美穂,湯浅秀人,河野潤一,横山俊史,星 信彦,北川 浩
    • Organizer
      第92回日本解剖学会近畿支部学術集会
    • Place of Presentation
      近畿大学(大阪府・狭山市)
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット回腸におけるtelocyteの免疫組織化学的同定2016

    • Author(s)
      万谷洋平,宮本和樹,西田美穂,湯浅秀人,増田なつみ,横山俊史,星 信彦,北川 浩
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学(神奈川県・藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 生理学的条件下のラットパイエル板におけるRANK/RANKLの発現および常在細菌の増殖による影響2016

    • Author(s)
      湯浅秀人,増田なつみ,西田美穂,河野潤一,横山俊史,万谷洋平,星 信彦,北川 浩
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学(神奈川県・藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット呼吸器におけるβ-defensin 1およびβ-defensin 2を介した分泌型の生体防御機構に関する免疫組織化学的研究2016

    • Author(s)
      増田なつみ,万谷洋平,西田美穂,湯浅秀人,河野潤一,横山俊史,星 信彦,北川 浩
    • Organizer
      第159回日本獣医学会学術集会
    • Place of Presentation
      日本大学(神奈川県・藤沢市)
    • Year and Date
      2016-09-06
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット小腸のPaneth細胞に連絡する粘膜固有層細胞の超微形態.2015

    • Author(s)
      万谷洋平,西田美穂, 湯浅秀人,増田なつみ,横山俊史,星 信彦,北川 浩
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      北里大学獣医学部(青森県・十和田市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Research-status Report
  • [Presentation] ラット呼吸器系におけるlysozymeおよびsPLA2の分泌上皮細胞に関する免疫組織化学的研究.2015

    • Author(s)
      増田なつみ,万谷洋平,西田美穂,湯浅秀人,河野潤一,横山俊史,星 信彦,北川 浩
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      北里大学獣医学部(青森県・十和田市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Research-status Report
  • [Presentation] ラットパイエル板濾胞被蓋上皮におけるToll-like receptor-2, -4および-9の発現に対する常在細菌増殖の影響.2015

    • Author(s)
      湯浅秀人,万谷洋平,増田なつみ,西田美穂,河野潤一,横山俊史,星 信彦,北川 浩
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      北里大学獣医学部(青森県・十和田市)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Research-status Report
  • [Presentation] The short-term effect of peptidoglycan injected into the intestinal lumen against host defense responses.2015

    • Author(s)
      Youhei MANTANI, Kazuki MIYAMOTO, Seiko MATSUMORI, Hideto YUASA, Natsumi MASUDA, Toshifumi YOKOYAMA, Nobuhiko HOSHI, Hiroshi KITAGAWA
    • Organizer
      17th International Congress of Mucosal Immunology
    • Place of Presentation
      Maritim hotel, Berlin, Germany
    • Year and Date
      2015-07-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Funded Workshop] 17th International Congress of Mucosal Immunology2015

    • Place of Presentation
      Maritim hotel, Berlin, Germany
    • Year and Date
      2015-07-14
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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