Roles of Superoxidedismutase in Central Glia for Protection from Oxidative Stress
| Project/Area Number |
15K07768
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
Nakamura Yoichi 大阪府立大学, 生命環境科学研究科, 教授 (90180413)
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| Co-Investigator(Kenkyū-buntansha) |
森山 光章 大阪府立大学, 生命環境科学研究科, 准教授 (20275283)
高野 桂 大阪府立大学, 生命環境科学研究科, 准教授 (50453139)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞外スパーオキシドディスムターゼ / アストロサイト / 脳浮腫 / プリオン蛋白 / エキセンディン4 / スーパーオキシドディスムターゼ / エクセンディン４ / EC-SOD / アミロイドβ / 細胞外SOD / スーパーオキシドディスミューターゼ / 低浸透圧刺激 |
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| Outline of Final Research Achievements |
Among three types of superoxidedismutase (SOD), extracellular type (EC-SOD) is abundant in astrocytes in CNS. We examined several stimulations on EC-SOD in astrocytes and found three interesting results. When the culture medium was diluted with water, as a brain edema model, EC-SOD activity increased significantly. The addition of exendin-4 (an agonist for GLP-1 receptor) increased the expression of EC-SOD in mRNA and protein. The stimulation with a fragment of prion protein (PrPc106-126) decreased EC-SOD activity to about 10%. These results suggest the importance of the studies focused on astrocytes for conquest of various central diseases due to oxidative stress.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Mechanism for increased hepatic glycerol synthesis in the citrin/mitochondria glycerol-3-phosphate dehydrogenase double-knockout mouse: Urine glycerol and glycerol 3-phosphate as potential diagnostic markers of human citrin deficiency.2015
Author(s)
Moriyama M, Fujimoto Y, Rikimaru S,Ushikai M, Kuroda E, Kawabe K, Takano K,Asakawa A, Inui A, Eto K, Kadowaki T, Sinasac DS, Okano Y, Yazaki M, Ikeda SI,Zhang C, Song YZ,Sakamoto O, Kure S, Mitsubuchi H, Endo F, Horiuchi M, Nakamura Y, Yamamura KI, Saheki T.
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Journal Title
Biochim Biophys Acta.
Volume: 印刷中
Issue: 9
Pages: 1787-1795
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] A benzoylmethane derivative inhibits lipopolysaccharide-induced NO production.2016
Author(s)
Katsura Takano, Kumiko Sugita, Natsumi Ishida, Mitsuaki Moriyama, Satoshi Hibino, Tominari Choshi, Rika Murakami, Masashi Yamada, Hiroto Suzuki, Osamu Hori, Yoichi Nakamura
Organizer
第89回日本薬理学会年会
Place of Presentation
神奈川県 パシフィコ横浜
Year and Date
2016-03-09
Related Report
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