| Project/Area Number |
15K07768
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
Nakamura Yoichi 大阪府立大学, 生命環境科学研究科, 教授 (90180413)
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| Co-Investigator(Kenkyū-buntansha) |
森山 光章 大阪府立大学, 生命環境科学研究科, 准教授 (20275283)
高野 桂 大阪府立大学, 生命環境科学研究科, 准教授 (50453139)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞外スパーオキシドディスムターゼ / アストロサイト / 脳浮腫 / プリオン蛋白 / エキセンディン4 / スーパーオキシドディスムターゼ / エクセンディン４ / EC-SOD / アミロイドβ / 細胞外SOD / スーパーオキシドディスミューターゼ / 低浸透圧刺激 |
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| Outline of Final Research Achievements |
Among three types of superoxidedismutase (SOD), extracellular type (EC-SOD) is abundant in astrocytes in CNS. We examined several stimulations on EC-SOD in astrocytes and found three interesting results. When the culture medium was diluted with water, as a brain edema model, EC-SOD activity increased significantly. The addition of exendin-4 (an agonist for GLP-1 receptor) increased the expression of EC-SOD in mRNA and protein. The stimulation with a fragment of prion protein (PrPc106-126) decreased EC-SOD activity to about 10%. These results suggest the importance of the studies focused on astrocytes for conquest of various central diseases due to oxidative stress.
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