Analysis of modification mechanism of reproductive regulation focusing on OGR1 family receptor
| Project/Area Number |
15K07772
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | OGR1 / ゴナドトロフ / プロトン / 生殖調節 / OGR1ファミリー受容体 / 性腺 |
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| Outline of Final Research Achievements |
Reproductive regulation is controlled along the hypothalamic-pituitary-gonadal axis pathway. Here we show that OGR1 is expressed in rat pituitary gonadotropic cells and a mouse gonadotropic cell line. We also revealed that OGR1 is involved in activation of gene promoter accompanying pH decrease in the gonadotropic cell line. Furthermore, it was suggested that OGR1 may be involved in hormone secretion response due to pH decrease. These results suggest that OGR1 may be involved in reproductive regulation.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR4.2017
Author(s)
J. Negishi, Y. Omori, M. Shindo, H. Takanashi, S. Musha, S. Nagayama, J. Hirayama, H. Nishina, T. Nakakura, C. Mogi, K. Sato, F. Okajima, Y. Mochimaru, H. Tomura
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Journal Title
J. Recept. Signal Transduct. Res.
Volume: -
Issue: 4
Pages: 401-408
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Two zebrafish G2A homologs activate multiple intracellular signaling pathways in acidic environment.2016
Author(s)
Y. Ichijo, Y. Mochimaru, M. Azuma, K. Satou, J. Negishi, T. Nakakura, N. Oshima, C. Mogi, K. Sato, K. Matsuda, F. Okajima, H. Tomura
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 469
Issue: 1
Pages: 81-86
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton- Sensing GPR4 in Extracellular Acidification-Induced Responses2015
Author(s)
Ayaka Tobo, Masayuki Tobo, Takashi Nakakura, Masashi Ebara, Hideaki Tomura, Chihiro Mogi, Dong-Soon Im, Naoya Murata, Atsushi Kuwabara, Saki Ito, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto, Michio Nakaya, Hitoshi Kurose, Koichi Sato, Fumikazu Okajima
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Journal Title
PLoS One.
Volume: 10
Issue: 6
Pages: e0129334-e0129334
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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