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Analysis of modification mechanism of reproductive regulation focusing on OGR1 family receptor

Research Project

Project/Area Number 15K07772
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrative animal science
Research InstitutionMeiji University

Principal Investigator

Tomura Hideaki  明治大学, 農学部, 専任教授 (70217553)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsOGR1 / ゴナドトロフ / プロトン / 生殖調節 / OGR1ファミリー受容体 / 性腺
Outline of Final Research Achievements

Reproductive regulation is controlled along the hypothalamic-pituitary-gonadal axis pathway. Here we show that OGR1 is expressed in rat pituitary gonadotropic cells and a mouse gonadotropic cell line. We also revealed that OGR1 is involved in activation of gene promoter accompanying pH decrease in the gonadotropic cell line. Furthermore, it was suggested that OGR1 may be involved in hormone secretion response due to pH decrease. These results suggest that OGR1 may be involved in reproductive regulation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (26 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (19 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] Metals differentially activate ovarian cancer G protein-coupled receptor 1 in various species.2018

    • Author(s)
      6.Mochimaru Y, Negishi J, Murakami S, Musha S, Sato K, Okajima F, Tomura H.
    • Journal Title

      Zoolog Sci.

      Volume: 35 Issue: 2 Pages: 109-114

    • DOI

      10.2108/zs170145

    • NAID

      40021514985

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Manganese and cobalt activate zebrafish ovarian cancer G-protein-coupled receptor 1 but not GPR42017

    • Author(s)
      J. Negishi, Y. Omori, M. Shindo, H. Takanashi, S. Musha, S. Nagayama, J. Hirayama, H. Nishina, T. Nakakura, C. Mogi, K. Sato, F. Okajima, Y. Mochimaru, H. Tomura
    • Journal Title

      J. Recept. Signal Transduct. Res.

      Volume: 37 Issue: 4 Pages: 401

    • DOI

      10.1080/10799893.2017.1298130

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Easy detection of hormone secretion from LβT2 cells by using Gaussia luciferase2017

    • Author(s)
      Satou K, Mochimaru Y, Nakakura T, Kusada T, Negishi J, Musha S, Yoshimura N, Kato Y, Tomura H
    • Journal Title

      Journal of Reproduction and Development

      Volume: 63 Issue: 2 Pages: 199-204

    • DOI

      10.1262/jrd.2016-174

    • NAID

      130007314627

    • ISSN
      0916-8818, 1348-4400
    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two zebrafish G2A homologs activate multiple intracellular signaling pathways in acidic environment2016

    • Author(s)
      Y. Ichijo, Y. Mochimaru, M. Azuma, K. Satou, J. Negishi, T. Nakakura, N. Oshima, C. Mogi, K. Sato, K. Matsuda, F. Okajima, H. Tomura
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 469 Issue: 1 Pages: 81

    • DOI

      10.1016/j.bbrc.2015.11.075

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characterization of imidazopyridine compounds as negative allosteric modulators of proton-sensing GPR4 in extracellular acidification-induced responses2015

    • Author(s)
      Ayaka Tobo, Masayuki Tobo, Takashi Nakakura, Masashi Ebara, Hideaki Tomura, Chihiro Mogi, Dong-Soon Im, Naoya Murata, Atsushi Kuwabara, Saki Ito, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto, Michio Nakaya, Hitoshi Kurose, Koichi Sato, Fumikazu Okajima
    • Journal Title

      PLoS One.

      Volume: 10 Issue: 6 Pages: e0129334-e0129334

    • DOI

      10.1371/journal.pone.0129334

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] G-protein-coupled receptor 4受容体のリガンド及び機能2015

    • Author(s)
      大嶋菜月、戸村秀明
    • Journal Title

      明治大学農学部研究報告

      Volume: 65 Pages: 1-7

    • NAID

      120005676965

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 創薬のターゲットとしてのovarian cancer G-protein-coupled receptor 12015

    • Author(s)
      持丸雄太、戸村秀明
    • Journal Title

      明治大学農学部研究報告

      Volume: 65 Pages: 9-16

    • NAID

      120005676966

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Effect of metal ions on the activation of zebrafish ovarian cancer G-protein-coupled receptor 1 and GPR42017

    • Author(s)
      Negishi J, Musha S, Nagayama S, Tomura H.
    • Organizer
      Fourth World Congress of Reproductive Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Metal ions may modulate protoninduced OGR1 activation2017

    • Author(s)
      Mochimaru Y, Murakami S, Yoshimura N, Tomura H.
    • Organizer
      Fourth World Congress of Reproductive Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] OGR1の金属応答性は生物種間で異なる.2017

    • Author(s)
      持丸雄太、戸村秀明
    • Organizer
      第32回日本下垂体研究会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ACTH産生細胞株におけるGPHRの機能解析2017

    • Author(s)
      村上奨、持丸雄太、戸村秀明
    • Organizer
      第32回日本下垂体研究会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゼブラフィッシュOGR1, GPR4の金属による応答解析2017

    • Author(s)
      武者詩織、根岸潤、永山純礼、持丸雄太、戸村秀明
    • Organizer
      第32回日本下垂体研究会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 金属イオンによるOGR1, GPR4を介した応答解析2017

    • Author(s)
      武者詩織、根岸潤、永山純礼、持丸雄太、戸村秀明
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 金属イオンによるOGR1活性化の差を生む部位の探索.2017

    • Author(s)
      村上奨、持丸雄太、東野瑚子、吉村名央、戸村秀明
    • Organizer
      Conbio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生物種による各金属イオンによるOGR1活性化様式の多様性.2016

    • Author(s)
      鳥海拓也, 持丸雄太, 金子涼, 吉村名央, 東野瑚子, 戸村秀明.
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ゼブラフィッシュOGR1は金属イオンにより活性化される2016

    • Author(s)
      高梨颯, 根岸潤, 大森由花, 武者詩織, 永山純礼, 戸村秀明
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 生物種間における金属イオンによるOGR1活性化の比較.2016

    • Author(s)
      持丸雄太, 根岸潤, 大森由花, 高梨颯, 武者詩織, 戸村秀明
    • Organizer
      第109回日本繁殖生物学会大会
    • Place of Presentation
      麻布大学
    • Year and Date
      2016-09-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of metal ions on the activation of zebrafish ovarian cancer G-protein-coupled receptor 12016

    • Author(s)
      Negishi J, Omori Y, Nagayama S, Tomura H.
    • Organizer
      International Symposium on Pituitary Gland and Related Systems
    • Place of Presentation
      ホノルル・ハワイ
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Proton activates OGR1, GPR4 and G2A homologs of zebrafish2016

    • Author(s)
      Mochimaru Y, Azuma M, Negishi J, Tomura H.
    • Organizer
      International Symposium on Pituitary Gland and Related Systems
    • Place of Presentation
      ホノルル・ハワイ
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Proton activates OGR1, GPR4 and G2A homologs of zebrafish.12016

    • Author(s)
      Mochimaru Y, Azuma M, Negishi J, Tomura H.
    • Organizer
      International Society for Stem Cell Research
    • Place of Presentation
      サンフランシスコ・カリフォルニア
    • Year and Date
      2016-06-22
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Metals activate ovarian cancer G-protein-coupled receptor 1 of zebrafish2015

    • Author(s)
      Jun Negishi, Yuka Omori, Hayate Takanashi, Tomoyuki Kusada, Hideaki Tomura
    • Organizer
      CompBiol 2015広島大会
    • Place of Presentation
      JMSアステールプラザ(広島)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Analysis of LbT2 cell responses through ovarian cancer G-protein coupled receptor 12015

    • Author(s)
      Yuta Mochimaru, Kazuhiro Satou, Mami Shindo, Yukio Kato, Hideaki Tomura
    • Organizer
      CompBiol 2015広島大会
    • Place of Presentation
      JMSアステールプラザ(広島)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] ガウシアルシフェラーゼを利用した高感度ホルモン分泌アッセイ系の構築の試み2015

    • Author(s)
      佐藤一裕,根岸潤,中倉敬,草田智之,加藤幸雄, 戸村秀明
    • Organizer
      第108回日本繁殖生物学会
    • Place of Presentation
      宮崎大学
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] プロトン刺激による性腺刺激ホルモン産生細胞株の応答解析2015

    • Author(s)
      持丸雄太, 新堂真実, 西田真実, 金子諒、加藤幸雄, 戸村秀明
    • Organizer
      第108回日本繁殖生物学会
    • Place of Presentation
      宮崎大学
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
  • [Presentation] ガウシアルシフェラーゼのLβT2細胞におけるホルモン分泌アッセイ系の構築への利用2015

    • Author(s)
      佐藤一裕,根岸潤,中倉敬,草田智之,大森由花, 加藤幸雄, 戸村秀明
    • Organizer
      第30回日本下垂体研究会
    • Place of Presentation
      宇奈月国際会館セレネ(富山)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Research-status Report
  • [Presentation] プロトン刺激によるマウス下垂体細胞株LβT2の応答解析2015

    • Author(s)
      持丸雄太, 新堂真実, 西田真実, 金子諒, 加藤幸雄, 戸村秀明
    • Organizer
      第30回日本下垂体研究会
    • Place of Presentation
      宇奈月国際会館セレネ(富山)
    • Year and Date
      2015-08-05
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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