Preparaion of Novel Anticancer Agents based on Isoquinoline Marine Natural Products
| Project/Area Number |
15K07873
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
Saito Naoki 明治薬科大学, 薬学部, 教授 (80142545)
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| Co-Investigator(Kenkyū-buntansha) |
木村 真也 明治薬科大学, 薬学部, 助手 (10632739)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 海洋天然物 / 抗腫瘍活性 / テトラヒドロイソキノリン / 全合成 / 殺細胞活性 / エクチナサイジン / レニエラマイシン / ラジカル反応 / 化学変換 / 構造活性相関 / 反応機構 / 構造解析 |
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| Outline of Final Research Achievements |
① Preparation of eleven new ecteinascidin derivatives to receive some additional proof of cytotoxicity profiles; ② Preparation of a variety of renieramycin derivatives for discovering highly potent anticancer activity; ③ The first total synthesis of renieramycin T; ④ Preparation of both right-half and left-had models of saframycin-renieramycins along with evaluation for cytotoxicity profiles; ⑤Total synthesis of renieramycin I and also Structure determination of 7-desmethylrenieramycin O; ⑥ Discovered a novel photo-transformation from methoxy-p-quinone into a characteristic highly substituted A-ring of ecteinascidins and renieramycin T.
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Report
(4 results)
Research Products
(39 results)
