• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of awareness in learning acquisition during eyeblink conditioning

Research Project

Project/Area Number 15K07910
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Physical pharmacy
Research InstitutionTokushima Bunri University

Principal Investigator

Kishimoto Yasushi  徳島文理大学, 薬学部, 教授 (90441592)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords瞬目反射条件づけ / 意識 / 睡眠 / 条件反射 / 学習 / アルツハイマー病 / 運動学習 / 覚醒 / 自閉症スペクトラム / 覚醒状態 / 記憶学習 / サル / 遺伝子改変マウス
Outline of Final Research Achievements

By using eyeblink conditioning, we analyzed the role of awareness/attention on learning acquisition and expression. Experiments in monkeys revealed that latent learning occurred regardless of arousal level, whereas in mice, there was a clear correlation between the arousal state and the expression of conditioned eyeblink responses. We also showed that the perception of surroundings and the degree of attention were strongly correlated with acquisition and expression of learning. By adapting various model animals to this experimental system, we attempted to develop a methodology leading to the development of a therapeutic strategy to overcome neurodegenerative diseases. In this process, we were able to elucidate the physiological role of monoacylglycerol lipase, MDGA1, and MDGA2 in the higher brain functions.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (31 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 8 results,  Acknowledgement Compliant: 4 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (7 results)

  • [Int'l Joint Research] The University of British Columbia(Canada)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Loss of Synapse Repressor MDGA1 Enhances Perisomatic Inhibition, Confers Resistance to Network Excitation, and Impairs Cognitive Function2017

    • Author(s)
      Steven A. Connor, Ina Ammendrup-Johnsen, Yasushi Kishimoto, Parisa Karimi Tari, Vedrana Cvetkovska, Takashi Harada, Daiki Ojima, Tohru Yamamoto, Yu Tian Wang, Ann Marie Craig
    • Journal Title

      Cell Rep.

      Volume: 21 Issue: 13 Pages: 3637

    • DOI

      10.1016/j.celrep.2017.11.109

    • URL

      https://pure.teikyo.jp/en/publications/cc74bd4e-c460-4c0e-998d-3a53912e11c3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Early contextual fear memory deficits in a double-transgenic amyloid-β precursor protein/presenilin 2 mouse model of Alzheimer’s disease.2017

    • Author(s)
      Yasushi Kishimoto, Kai Fukumoto, Mika Nagai, Ayaka Mizuguchi, Yuiko Kobayashi.
    • Journal Title

      J. Alzheimers. Dis.

      Volume: 2017 Pages: 8584205-8584205

    • DOI

      10.1155/2017/8584205

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered cortical dynamics and cognitive function upon haploinsufficiency of the autism-linked excitatory synaptic suppressor MDGA22016

    • Author(s)
      S. A. Connor, I. Ammendrup-Johnsen, A. W. Chan, Y. Kishimoto, C. Murayama, N. Kurihara, A. Tada, Y. Ge, H. Lu, R. Yan, J. M. LeDue, H. Matsumoto, H. Kiyonari, Y. Kirino, F. Matsuzaki, T. Suzuki, T. H. Murphy, Y. T. Wang, T. Yamamoto, A. M. Craig
    • Journal Title

      Neuron

      Volume: 91 Issue: 5 Pages: 1052-1068

    • DOI

      10.1016/j.neuron.2016.08.016

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Data on amyloid precursor protein accumulation, spontaneous physical activity, and motor learning after traumatic brain injury in the triple-transgenic mouse model of Alzheimer׳s disease2016

    • Author(s)
      Kishimoto Y, Shishido H, Sawanishi M, Toyota Y, Ueno M, Kubota T, Kirino Y, Tamiya T, Kawai N
    • Journal Title

      Data Brief.

      Volume: 9 Pages: 62

    • DOI

      10.1016/j.dib.2016.08.041

    • URL

      https://pure.teikyo.jp/en/publications/9042e109-3e2b-4636-a336-41893cba1dd8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Traumatic brain injury accelerates amyloid-β deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer's disease2016

    • Author(s)
      Shishido H, Kishimoto Y, Kawai N, Toyota Y, Ueno M, Kubota T, Kirino Y, Tamiya T.
    • Journal Title

      Neurosci Lett.

      Volume: 629 Pages: 62

    • DOI

      10.1016/j.neulet.2016.06.066

    • URL

      https://localhost/en/publications/28dd4f61-7cc0-42a8-8b8e-d0a7a2a8450c

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 瞬目反射条件づけ2016

    • Author(s)
      岸本泰司
    • Journal Title

      脳科学辞典

      Volume: -

    • DOI

      10.14931/bsd.6400

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Task-specific enhancement of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase, the major hydrolyzing enzyme of the endocannabinoid 2-arachidonoylglycerol2015

    • Author(s)
      Kishimoto Y, Cagniard B, Yamazaki M, Nakayama J, Sakimura K, Kirino Y, Kano M.
    • Journal Title

      Front. Behav. Neurosci.

      Volume: 9 Issue: JUNE Pages: 134-134

    • DOI

      10.3389/fnbeh.2015.00134

    • URL

      https://pure.teikyo.jp/en/publications/2dbf304d-3bc8-43b9-abad-0825f823169d

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Implicit memory in monkeys: class FormattedString { value: Development of a delay eyeblink conditioning system with parallel electromyographic and high-speed video measurements }2015

    • Author(s)
      Kishimoto Y, Yamamoto S, Suzuki K, Toyoda H, Kano M, Tsukada H, Kirino Y
    • Journal Title

      PloS one

      Volume: 10 Issue: 6 Pages: e0129828-e0129828

    • DOI

      10.1371/journal.pone.0129828

    • URL

      https://pure.teikyo.jp/en/publications/e481ce02-4cf3-45c7-8b94-6da345259488

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] サルの学習実験による「無意識の記憶」の再評価2015

    • Author(s)
      岸本泰司
    • Journal Title

      香川県薬剤師会会誌

      Volume: - Pages: 42-45

    • Related Report
      2015 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] 記憶と心のメカニズム -遺伝子改変マウスを用いた実験から-2018

    • Author(s)
      岸本泰司
    • Organizer
      第138回日本薬学会中国四国支部例会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 「MDGA2は興奮性シナプス形成抑制因子であり、そのヘミ欠損は興奮性の亢進とASD様の行動異常をもたらす2017

    • Author(s)
      1.山本融、Connor S.A.、岸本泰司、Ammendrup-Johnsen I、栗原直和、村山千明、尾嶋大喜、Hossain R、鈴木利治、Craig AM
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      東北大学
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
  • [Presentation] シナプス形成抑制因子MDGA2のヘミ欠損は興奮/抑制バランスの興奮側へのシフトによるASD様の社会性行動異常をもたらす2017

    • Author(s)
      山本融、Connor A Steven、岸本泰司、Ammendrup-Johnsen Ina、栗原直和、村山千明、尾嶋大喜、Hossain Razib、鈴木利治、Craig Ann Marie
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] プラセボ反応の脳内メカニズム (公募シンポジウム プラセボ効果とは何かー心理学と神経科学からのアプローチー)2017

    • Author(s)
      岸本泰司
    • Organizer
      日本心理学会第81回大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Mdga2 遺伝子ヘテロ欠損マウスの学習障害に対するR-Baclofenの効果2017

    • Author(s)
      多田篤史、福本絵、天野翔太、尾嶋大喜、山本融、岸本泰司
    • Organizer
      第56回日本薬学会日本薬剤師会日本病院薬剤師会中国四国支部学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Traumatic brain injury accelerates amyloid-β deposition and impairs learning and memory in the triple-transgenic mouse model of Alzheimer’s disease2017

    • Author(s)
      Yutaka Kirino, Hajime Shishido, Nobuyui Kawai, Yasunori Toyota, Takashi Tamiya, Takashi Kubota, Masaki Ueno, Yasushi Kishimoto.
    • Organizer
      Neuroscience 2017 (北米神経科学学会)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MDGA2は興奮性シナプス形成抑制因子であり、そのヘミ欠損は興奮性の亢進とASD様の行動異常をもたらす2017

    • Author(s)
      山本融、Connor A Steven、岸本泰司、Ammendrup-Johnsen Ina、栗原直和、村山千明、尾嶋大喜、Hossain Razib、鈴木利治、Craig Ann Marie
    • Organizer
      日本薬学会第137年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 記憶・忘却・社会性の分子機構2017

    • Author(s)
      岸本泰司
    • Organizer
      第9回バイオナノシステムズ研究会
    • Place of Presentation
      徳島文理大学香川薬学部
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] シナプス形成抑制因子MDGA2のヘミ欠失マウスは興奮性入力の亢進によりもたらされる自閉症スペクトラム障害のモデルとなる2016

    • Author(s)
      山本融、Connor S、岸本泰司、Ina A-J、栗原直和、村山千明、尾嶋大喜、Hossain R、鈴木利治、Craig AM
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Haploinsufficiency of the neuronal surface protein MDGA2 enhances excitatory synapse development, alters cortical circuit dynamics and yields behavioral phenotypes consistent with autism in mice2016

    • Author(s)
      Connor S.A., Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Kurihara N, Tada A, Ge Y, Yan R, LeDue J, Matsumoto H, Kiyonari H, Kirino Y, Matsuzaki F, Suzuki T, Ojima D, Murphy T.H., Wang Y, Yamamoto T, Craig A
    • Organizer
      Neuroscience 2016 (北米神経科学学会)
    • Place of Presentation
      San Diego, CA, U.S.A.
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
  • [Presentation] Altered social and cognitive functions upon haploinsufficiency of the excitatory synaptic suppressor MDGA2 in a mouse model of autism2016

    • Author(s)
      岸本泰司、栗原直和、村山千明、多田篤史、桐野豊、山本融
    • Organizer
      日本生物物理学会第8回中国四国支部大会
    • Place of Presentation
      高松テルサ (高松勤労者総合福祉センター)
    • Year and Date
      2016-05-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 脳の『行き過ぎ』を抑えるしくみ2016

    • Author(s)
      岸本泰司
    • Organizer
      第8回3大学学術交流会プログラム」「うどん県で健やかに暮らそう~健康寿命を延ばす~
    • Place of Presentation
      徳島文理大学村崎サイホール
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] マウスMDGAs遺伝子の欠損は社会性行動を減少させる2015

    • Author(s)
      栗原直和、村山千明、山本融、岸本泰司
    • Organizer
      第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高知市文化プラザ
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
  • [Presentation] Task-specific impairment of hippocampus-dependent learning in mice deficient in monoacylglycerol lipase2015

    • Author(s)
      Yasushi Kishimoto, Barbara Cagniard, Maya Yamazaki, Junko Nakayama, Kenji Sakimura, Yutaka Kirino, Masanobu Kano
    • Organizer
      第53回日本生物物理学会年会
    • Place of Presentation
      金沢大学、金沢市
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/read0109518/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 生命物理化学講座

    • URL

      http://kp.bunri-u.ac.jp/kph/index-7-ja.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] Google Scholar

    • URL

      https://scholar.google.com/citations?user=vR_mw44AAAAJ&hl=ja

    • Related Report
      2017 Annual Research Report
  • [Remarks] 生命物理化学講座(研究室のwbページ)

    • URL

      http://kp.bunri-u.ac.jp/kph/index-7.html

    • Related Report
      2016 Research-status Report
  • [Remarks] 研究内容紹介サイト

    • URL

      http://kp.bunri-u.ac.jp/kph16/kishimoto.html

    • Related Report
      2016 Research-status Report
  • [Remarks] 徳島文理大学香川薬学部物理化学講座

    • URL

      http://kp.bunri-u.ac.jp/kph/index-7.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 研究の現場から:サル、睡眠中も条件反射解明

    • URL

      http://mainichi.jp/articles/20150707/ddl/k39/040/576000c

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi