Identification and characterization of the cell surface marker protein that can distinguish between hematopoietic and myocardial progenitor cells
| Project/Area Number |
15K07961
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
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Principal Investigator |
KAWABATA Kenji 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 幹細胞制御プロジェクト, プロジェクトリーダー (50356234)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分化 / iPS細胞 / 中胚葉 / 血液 / 心筋 / 心筋細胞 / 血液細胞 / マーカー |
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| Outline of Final Research Achievements |
Coxsackievirus and adenovirus receptor (CAR) was identified as adenovirus entry receptor. We found that there were CAR-positive and -negative cells in mesodermal (Flk-1 positive) cells derived from human ES and iPS cells. Flk-1-positive and CAR-positive cells could differentiate into myocardial progenitor cells. On the other hand, Flk-1-positive and CAR-negative cells could differentiate into hematopoietic and endothelial progenitor cells. These results suggest that CAR is an appropriate cell surface marker that can distinguish between hematopoietic and myocardial progenitor cells.
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Report
(4 results)
Research Products
(5 results)
