Identification of innate immune ligands to induce the protection from MRSA infection
Project/Area Number |
15K08056
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Environmental and hygienic pharmacy
|
Research Institution | Nagasaki International University |
Principal Investigator |
|
Research Collaborator |
LEE Bok-Leul 釜山大学校, 薬学部, 教授
TAKAHASHI Kazue Massachusetts General Hospital, Assistant Professor
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 細菌宿主相互作用 / 樹状細胞 / 黄色ブドウ球菌 / 免疫賦活化 / 細胞壁タイコ酸 |
Outline of Final Research Achievements |
Staphylococcus aureus infection induces IL-23 that is critical for its biological defense, however the bacterial ligand molecules for the IL-23-induction have been unknown. We established a bioassay system to evaluate the IL-23 inducing activity by using a cultured human dendritic cell line and found that there were at least two molecules for the induction; one was wall teichoic acids (WTA) and the other was unidentified. Biochemical analyses using cell wall fractions derived from WTA modification enzymes revealed that a complete modified structure of WTA was not necessary for the IL-23 secretion.
|
Report
(4 results)
Research Products
(13 results)
-
-
-
-
-
-
-
[Journal Article] Adsorption of Staphylococcus viruses S13´ and S24-1 on Staphylococcus aureus strains with different glycosidic linkage patterns of wall teichoic acids.2017
Author(s)
Uchiyama, J., Taniguchi, M., Kurokawa, K., Takemura-Uchiyama, I., Ujihara, T., Shimakura, H., Sakaguchi, Y., Murakami, H., Sakaguchi, M., Matsuzaki, S.
-
Journal Title
J. Gen. Virol.
Volume: 98(8)
Issue: 8
Pages: 2171-2180
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Surface glycopolymers are crucial for in vitro anti-wall teichoic acid IgG-mediated complement activation and opsonophagocytosis of Staphylococcus aureus.2015
Author(s)
Lee JH, Kim NH, Winstel V, Kurokawa K, Larsen J, An JH, Khan A, Seong MY, Lee MJ, Andersen PS, Peschel A, and Lee BL.
-
Journal Title
Infect Immun.
Volume: 83
Issue: 11
Pages: 4247-4255
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-